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- W2982178593 abstract "Elaiophylins belong to a special family of 16-membered macrodiolides with C2-symmetry. They have exhibited remarkable biological activities, such as antimicrobial, anthelmintic, anticancer, immunosuppressive, anti-inflammatory, antiviral, and α-glucosidase inhibitory activities. A member of elaiophylins, efomycin M, is as a specific small molecule inhibitor of selectin in preclinical trial for the treatment of psoriasis, ischemia-reperfusion, and allergy. The biosynthetic investigation of elaiophylins has uncovered a unique thioesterase, which is responsible for the formation of C2-symmetric diolide. We herein summarize the natural occurrence, bioactivity, and biosynthesis of elaiophylins covering the literatures from 1959 to 2019. Hopefully, this review will inspire further research interests of these compounds and encourage the discovery of new analogues by metabolic engineering or genome mining." @default.
- W2982178593 created "2019-11-01" @default.
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- W2982178593 date "2019-10-25" @default.
- W2982178593 modified "2023-10-17" @default.
- W2982178593 title "Natural Occurrence, Bioactivity and Biosynthesis of Elaiophylin Analogues" @default.
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- W2982178593 doi "https://doi.org/10.3390/molecules24213840" @default.
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