FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982183856> ?p ?o ?g. }

• W2982183856 endingPage "15" @default.
• W2982183856 startingPage "8" @default.
• W2982183856 abstract "Background Reliable assays to measure direct oral anticoagulant (DOAC) levels and their activity in critical situations are needed. Drug levels alone are not representative of the effect of DOACs on an individual's coagulation. We developed a technique that provides direct assessment of the global effect of rivaroxaban on the individual's coagulation in addition to plasma concentrations. Methods DOAC concentrations were determined in fifty patients using rivaroxaban, with the new assay, Xross-CAT. The effect of rivaroxaban on coagulation (activity) was measured with thrombin generation (TG) in platelet poor plasma using 5 pM tissue factor on the same device. The levels were validated with the Biophen DiXal assay. The prothrombin time (PT) and dilute Russell viper venom time (dRVVT) were performed to estimate the effect on coagulation. Results The variability of Xross-CAT was below 12%. Xross-CAT correlates well with Biophen DiXaI (rs = 0.885). The bias, determined by Bland-Altman analysis, was 4.9% and the Passing-Bablok equation was y = 1.1x − 2.1. The correlation of plasma levels with TG was moderate (ETP rs = −0.548; Peak rs = −0.559), as for the PT (rs = 0.739) and the dRVVT (rs = 0.692). Conclusions Xross-CAT shows a good correlation with Biophen DiXaI that was previously confirmed to accurately assess rivaroxaban levels. Bleeding and thrombotic complications are not necessarily associated with drug levels and could be influenced by concomitant risk factors. The main benefit of Xross-CAT is that it can be performed simultaneously with thrombin generation, providing an overview of the global anticoagulation status of a patient in relation to circulating DOAC levels." @default.
• W2982183856 created "2019-11-01" @default.
• W2982183856 creator A5000944048 @default.
• W2982183856 creator A5009872372 @default.
• W2982183856 creator A5062105871 @default.
• W2982183856 creator A5078686392 @default.
• W2982183856 date "2019-12-01" @default.
• W2982183856 modified "2023-09-25" @default.
• W2982183856 title "Concomitant assessment of rivaroxaban concentration and its impact on thrombin generation" @default.
• W2982183856 cites W1489399279 @default.
• W2982183856 cites W1894683384 @default.
• W2982183856 cites W1970393874 @default.
• W2982183856 cites W1971011626 @default.
• W2982183856 cites W1985390039 @default.
• W2982183856 cites W2001598988 @default.
• W2982183856 cites W2009433302 @default.
• W2982183856 cites W2011936209 @default.
• W2982183856 cites W2016754244 @default.
• W2982183856 cites W2022828223 @default.
• W2982183856 cites W2025070897 @default.
• W2982183856 cites W2031847335 @default.
• W2982183856 cites W2032524450 @default.
• W2982183856 cites W2033408014 @default.
• W2982183856 cites W2037553602 @default.
• W2982183856 cites W2047927620 @default.
• W2982183856 cites W2066098573 @default.
• W2982183856 cites W2071039800 @default.
• W2982183856 cites W2085073510 @default.
• W2982183856 cites W2096246254 @default.
• W2982183856 cites W2096361927 @default.
• W2982183856 cites W2096808849 @default.
• W2982183856 cites W2097854437 @default.
• W2982183856 cites W2119768870 @default.
• W2982183856 cites W2122004095 @default.
• W2982183856 cites W2136489990 @default.
• W2982183856 cites W2145323902 @default.
• W2982183856 cites W2146593044 @default.
• W2982183856 cites W2153339257 @default.
• W2982183856 cites W2157224841 @default.
• W2982183856 cites W2157833432 @default.
• W2982183856 cites W2158014557 @default.
• W2982183856 cites W2163853479 @default.
• W2982183856 cites W2194419520 @default.
• W2982183856 cites W2198635349 @default.
• W2982183856 cites W2319663405 @default.
• W2982183856 cites W2339509640 @default.
• W2982183856 cites W2464582306 @default.
• W2982183856 cites W2507210462 @default.
• W2982183856 cites W2539722649 @default.
• W2982183856 cites W2548076162 @default.
• W2982183856 cites W2591915456 @default.
• W2982183856 cites W2738356922 @default.
• W2982183856 cites W2749380187 @default.
• W2982183856 cites W2755375976 @default.
• W2982183856 cites W2769760280 @default.
• W2982183856 cites W2789359247 @default.
• W2982183856 cites W2801340189 @default.
• W2982183856 cites W2802751719 @default.
• W2982183856 cites W2889256743 @default.
• W2982183856 cites W2164165213 @default.
• W2982183856 doi "https://doi.org/10.1016/j.thromres.2019.09.037" @default.
• W2982183856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31677449" @default.
• W2982183856 hasPublicationYear "2019" @default.
• W2982183856 type Work @default.
• W2982183856 sameAs 2982183856 @default.
• W2982183856 citedByCount "4" @default.
• W2982183856 countsByYear W29821838562020 @default.
• W2982183856 countsByYear W29821838562021 @default.
• W2982183856 countsByYear W29821838562022 @default.
• W2982183856 countsByYear W29821838562023 @default.
• W2982183856 crossrefType "journal-article" @default.
• W2982183856 hasAuthorship W2982183856A5000944048 @default.
• W2982183856 hasAuthorship W2982183856A5009872372 @default.
• W2982183856 hasAuthorship W2982183856A5062105871 @default.
• W2982183856 hasAuthorship W2982183856A5078686392 @default.
• W2982183856 hasConcept C126322002 @default.
• W2982183856 hasConcept C2776301958 @default.
• W2982183856 hasConcept C2777292125 @default.
• W2982183856 hasConcept C2777664302 @default.
• W2982183856 hasConcept C2778205648 @default.
• W2982183856 hasConcept C2778382381 @default.
• W2982183856 hasConcept C2778661090 @default.
• W2982183856 hasConcept C2779161974 @default.
• W2982183856 hasConcept C2779384505 @default.
• W2982183856 hasConcept C2992750412 @default.
• W2982183856 hasConcept C3018972837 @default.
• W2982183856 hasConcept C3020079912 @default.
• W2982183856 hasConcept C71924100 @default.
• W2982183856 hasConcept C89560881 @default.
• W2982183856 hasConcept C90924648 @default.
• W2982183856 hasConceptScore W2982183856C126322002 @default.
• W2982183856 hasConceptScore W2982183856C2776301958 @default.
• W2982183856 hasConceptScore W2982183856C2777292125 @default.
• W2982183856 hasConceptScore W2982183856C2777664302 @default.
• W2982183856 hasConceptScore W2982183856C2778205648 @default.
• W2982183856 hasConceptScore W2982183856C2778382381 @default.
• W2982183856 hasConceptScore W2982183856C2778661090 @default.
• W2982183856 hasConceptScore W2982183856C2779161974 @default.

• next