FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982197129> ?p ?o ?g. }

• W2982197129 endingPage "122" @default.
• W2982197129 startingPage "118" @default.
• W2982197129 abstract "Aspirin is indispensable in secondary prevention of ischemic events in patients with coronary artery disease (CAD). However, insufficient platelet inhibition despite aspirin medication is frequent. This is referred to as high on-treatment platelet reactivity (HTPR). Nevertheless, if this is associated with clinical outcome instead of only laboratory phenomenon remains unclear so far. In this study, we test whether patients with ischemic events have higher platelet reactivity despite aspirin medication than patients without ischemic events. In this prospective study of 72 CAD patients, we determined pharmacodynamic response to aspirin by arachidonic acid induced aggregation via light-transmission aggregometry and expressed as maximum of aggregation (MoA). During a mean follow-up duration of 3.2 years, major adverse cardiac and cerebrovascular events (MACCE), mortality, non-ST-elevation myocardial infarction (NSTEMI), and stroke were assessed as endpoints via yearly telephone interviews with the treating physician of the patients. Patients who suffered from MACCE, death, and NSTEMI had a significantly higher MoA than those without (MACCE: 5.4 vs. 16.4%, <i>p</i> &#x3c; 0.05; death: 5.6 vs. 16.8%, <i>p</i> &#x3c; 0.05; NSTEMI: 1.8 vs. 21%, <i>p</i> &#x3c; 0.001). MoA did not differ with regard to the occurrence of stroke (10.1 vs. 14.9%, <i>p</i> = 0.59). Patients with MACCE, death, and NSTEMI show enhanced platelet reactivity despite aspirin medication as compared to patients without ischemic events. Hence, insufficient response to aspirin medication should be regarded as risk factor for ischemic events in CAD patients. Further trials are needed to assess options to overcome HTPR to aspirin." @default.
• W2982197129 created "2019-11-01" @default.
• W2982197129 creator A5000317510 @default.
• W2982197129 creator A5001441700 @default.
• W2982197129 creator A5007105515 @default.
• W2982197129 creator A5012486228 @default.
• W2982197129 creator A5012690964 @default.
• W2982197129 creator A5014009236 @default.
• W2982197129 creator A5015282079 @default.
• W2982197129 creator A5016472370 @default.
• W2982197129 creator A5016582092 @default.
• W2982197129 creator A5019007539 @default.
• W2982197129 creator A5019007906 @default.
• W2982197129 creator A5020426952 @default.
• W2982197129 creator A5030979871 @default.
• W2982197129 creator A5033133878 @default.
• W2982197129 creator A5048288493 @default.
• W2982197129 creator A5053206701 @default.
• W2982197129 creator A5067294172 @default.
• W2982197129 creator A5087788813 @default.
• W2982197129 date "2019-10-22" @default.
• W2982197129 modified "2023-09-26" @default.
• W2982197129 title "Enhanced Platelet Reactivity under Aspirin Medication and Major Adverse Cardiac and Cerebrovascular Events in Patients with Coronary Artery Disease" @default.
• W2982197129 cites W1476752324 @default.
• W2982197129 cites W1516646250 @default.
• W2982197129 cites W1975040491 @default.
• W2982197129 cites W1988143463 @default.
• W2982197129 cites W1993232626 @default.
• W2982197129 cites W2003056887 @default.
• W2982197129 cites W2008333987 @default.
• W2982197129 cites W2011327495 @default.
• W2982197129 cites W2035765129 @default.
• W2982197129 cites W2067584597 @default.
• W2982197129 cites W2091394736 @default.
• W2982197129 cites W2146364648 @default.
• W2982197129 cites W2161043271 @default.
• W2982197129 cites W2165026522 @default.
• W2982197129 cites W2298123402 @default.
• W2982197129 cites W2341453243 @default.
• W2982197129 cites W2383975075 @default.
• W2982197129 cites W2410290453 @default.
• W2982197129 cites W2423438151 @default.
• W2982197129 cites W2589188836 @default.
• W2982197129 cites W2592527212 @default.
• W2982197129 cites W2789491843 @default.
• W2982197129 cites W2792964904 @default.
• W2982197129 cites W2884727639 @default.
• W2982197129 cites W2887334335 @default.
• W2982197129 cites W2892809417 @default.
• W2982197129 cites W2894039794 @default.
• W2982197129 cites W2897370011 @default.
• W2982197129 cites W2940459858 @default.
• W2982197129 cites W2963599700 @default.
• W2982197129 doi "https://doi.org/10.1159/000503582" @default.
• W2982197129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31639801" @default.
• W2982197129 hasPublicationYear "2019" @default.
• W2982197129 type Work @default.
• W2982197129 sameAs 2982197129 @default.
• W2982197129 citedByCount "7" @default.
• W2982197129 countsByYear W29821971292020 @default.
• W2982197129 countsByYear W29821971292021 @default.
• W2982197129 countsByYear W29821971292022 @default.
• W2982197129 crossrefType "journal-article" @default.
• W2982197129 hasAuthorship W2982197129A5000317510 @default.
• W2982197129 hasAuthorship W2982197129A5001441700 @default.
• W2982197129 hasAuthorship W2982197129A5007105515 @default.
• W2982197129 hasAuthorship W2982197129A5012486228 @default.
• W2982197129 hasAuthorship W2982197129A5012690964 @default.
• W2982197129 hasAuthorship W2982197129A5014009236 @default.
• W2982197129 hasAuthorship W2982197129A5015282079 @default.
• W2982197129 hasAuthorship W2982197129A5016472370 @default.
• W2982197129 hasAuthorship W2982197129A5016582092 @default.
• W2982197129 hasAuthorship W2982197129A5019007539 @default.
• W2982197129 hasAuthorship W2982197129A5019007906 @default.
• W2982197129 hasAuthorship W2982197129A5020426952 @default.
• W2982197129 hasAuthorship W2982197129A5030979871 @default.
• W2982197129 hasAuthorship W2982197129A5033133878 @default.
• W2982197129 hasAuthorship W2982197129A5048288493 @default.
• W2982197129 hasAuthorship W2982197129A5053206701 @default.
• W2982197129 hasAuthorship W2982197129A5067294172 @default.
• W2982197129 hasAuthorship W2982197129A5087788813 @default.
• W2982197129 hasConcept C111113717 @default.
• W2982197129 hasConcept C112705442 @default.
• W2982197129 hasConcept C126322002 @default.
• W2982197129 hasConcept C127413603 @default.
• W2982197129 hasConcept C164705383 @default.
• W2982197129 hasConcept C2777628954 @default.
• W2982197129 hasConcept C2777849778 @default.
• W2982197129 hasConcept C2778213512 @default.
• W2982197129 hasConcept C2780645631 @default.
• W2982197129 hasConcept C3018697912 @default.
• W2982197129 hasConcept C500558357 @default.
• W2982197129 hasConcept C71924100 @default.
• W2982197129 hasConcept C78519656 @default.
• W2982197129 hasConcept C89560881 @default.
• W2982197129 hasConceptScore W2982197129C111113717 @default.
• W2982197129 hasConceptScore W2982197129C112705442 @default.
• W2982197129 hasConceptScore W2982197129C126322002 @default.

• next