Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982206578> ?p ?o ?g. }
- W2982206578 endingPage "104646" @default.
- W2982206578 startingPage "104646" @default.
- W2982206578 abstract "L-dopa induced dyskinesia (LID) is a debilitating side-effect of the primary treatment used in Parkinson's disease (PD), l-dopa. Here we investigate the effect of HU-308, a cannabinoid CB2 receptor agonist, on LIDs. Utilizing a mouse model of PD and LIDs, induced by 6-OHDA and subsequent l-dopa treatment, we show that HU-308 reduced LIDs as effectively as amantadine, the current frontline treatment. Furthermore, treatment with HU-308 plus amantadine resulted in a greater anti-dyskinetic effect than maximally achieved with HU-308 alone, potentially suggesting a synergistic effect of these two treatments. Lastly, we demonstrated that treatment with HU-308 and amantadine either alone, or in combination, decreased striatal neuroinflammation, a mechanism which has been suggested to contribute to LIDs. Taken together, our results suggest pharmacological treatments with CB2 agonists merit further investigation as therapies for LIDs in PD patients. Furthermore, since CB2 receptors are thought to be primarily expressed on, and signal through, glia, our data provide weight to suggestion that neuroinflammation, or more specifically, altered glial function, plays a role in development of LIDs." @default.
- W2982206578 created "2019-11-01" @default.
- W2982206578 creator A5023666598 @default.
- W2982206578 creator A5050488901 @default.
- W2982206578 creator A5077266564 @default.
- W2982206578 creator A5084713074 @default.
- W2982206578 date "2020-02-01" @default.
- W2982206578 modified "2023-10-14" @default.
- W2982206578 title "Targeting the cannabinoid receptor CB2 in a mouse model of l-dopa induced dyskinesia" @default.
- W2982206578 cites W1569924411 @default.
- W2982206578 cites W1594747697 @default.
- W2982206578 cites W1596640114 @default.
- W2982206578 cites W1929488495 @default.
- W2982206578 cites W1963537018 @default.
- W2982206578 cites W1965888651 @default.
- W2982206578 cites W1966260988 @default.
- W2982206578 cites W1966443363 @default.
- W2982206578 cites W1982535961 @default.
- W2982206578 cites W1989475543 @default.
- W2982206578 cites W1990616075 @default.
- W2982206578 cites W1998629168 @default.
- W2982206578 cites W1998937162 @default.
- W2982206578 cites W2002785222 @default.
- W2982206578 cites W2007143406 @default.
- W2982206578 cites W2007751663 @default.
- W2982206578 cites W2010395737 @default.
- W2982206578 cites W2010396882 @default.
- W2982206578 cites W2012624148 @default.
- W2982206578 cites W2015264989 @default.
- W2982206578 cites W2018810438 @default.
- W2982206578 cites W2020714245 @default.
- W2982206578 cites W2023243943 @default.
- W2982206578 cites W2025783008 @default.
- W2982206578 cites W2028727583 @default.
- W2982206578 cites W2033128580 @default.
- W2982206578 cites W2034176184 @default.
- W2982206578 cites W2034640913 @default.
- W2982206578 cites W2035769824 @default.
- W2982206578 cites W2038636807 @default.
- W2982206578 cites W2041964216 @default.
- W2982206578 cites W2044784707 @default.
- W2982206578 cites W2062319694 @default.
- W2982206578 cites W2074975957 @default.
- W2982206578 cites W2078747341 @default.
- W2982206578 cites W2081485057 @default.
- W2982206578 cites W2082237701 @default.
- W2982206578 cites W2094874028 @default.
- W2982206578 cites W2110992486 @default.
- W2982206578 cites W2112391315 @default.
- W2982206578 cites W2119826244 @default.
- W2982206578 cites W2133773712 @default.
- W2982206578 cites W2146663965 @default.
- W2982206578 cites W2163150813 @default.
- W2982206578 cites W2258636851 @default.
- W2982206578 cites W2472577276 @default.
- W2982206578 cites W2502465441 @default.
- W2982206578 cites W2509149624 @default.
- W2982206578 cites W2529082504 @default.
- W2982206578 cites W2568346105 @default.
- W2982206578 cites W2572710398 @default.
- W2982206578 cites W2582277308 @default.
- W2982206578 cites W2606527202 @default.
- W2982206578 cites W2616733389 @default.
- W2982206578 cites W2622807556 @default.
- W2982206578 cites W2754740801 @default.
- W2982206578 cites W2781755317 @default.
- W2982206578 cites W2786577015 @default.
- W2982206578 cites W2792313334 @default.
- W2982206578 cites W2797844043 @default.
- W2982206578 cites W2804685648 @default.
- W2982206578 cites W2886046928 @default.
- W2982206578 cites W2886215053 @default.
- W2982206578 cites W2886637474 @default.
- W2982206578 cites W2891378929 @default.
- W2982206578 cites W2907517025 @default.
- W2982206578 cites W2913221496 @default.
- W2982206578 cites W2914756534 @default.
- W2982206578 cites W2924973872 @default.
- W2982206578 cites W2954849921 @default.
- W2982206578 doi "https://doi.org/10.1016/j.nbd.2019.104646" @default.
- W2982206578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31669673" @default.
- W2982206578 hasPublicationYear "2020" @default.
- W2982206578 type Work @default.
- W2982206578 sameAs 2982206578 @default.
- W2982206578 citedByCount "18" @default.
- W2982206578 countsByYear W29822065782020 @default.
- W2982206578 countsByYear W29822065782021 @default.
- W2982206578 countsByYear W29822065782022 @default.
- W2982206578 countsByYear W29822065782023 @default.
- W2982206578 crossrefType "journal-article" @default.
- W2982206578 hasAuthorship W2982206578A5023666598 @default.
- W2982206578 hasAuthorship W2982206578A5050488901 @default.
- W2982206578 hasAuthorship W2982206578A5077266564 @default.
- W2982206578 hasAuthorship W2982206578A5084713074 @default.
- W2982206578 hasBestOaLocation W29822065781 @default.
- W2982206578 hasConcept C126322002 @default.
- W2982206578 hasConcept C148001335 @default.
- W2982206578 hasConcept C15744967 @default.