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• W2982208564 startingPage "37" @default.
• W2982208564 abstract "Betaglycan binds inhibin A with higher affinity than inhibin B. Ablation of betaglycan in pituitary gonadotropes impairs inhibin A, but not inhibin B action in mice. Contrary to previous reports, IGSF1 is not an inhibin B coreceptor. Loss of function mutations in IGSF1 cause central hypothyroidism in humans and mice. There is an inhibin B coreceptor in the pituitary gland awaiting discovery. Inhibins are gonadal hormones that suppress follicle-stimulating hormone (FSH) synthesis by pituitary gonadotrope cells. The structurally related activins stimulate FSH by signaling through complexes of type I and type II receptors. Two models of inhibin action were proposed in 2000. First, inhibins function as competitive receptor antagonists, binding activin type II receptors with high affinity in the presence of the TGF-β type III coreceptor, betaglycan. Second, immunoglobulin superfamily, member 1 (IGSF1, then called p120) was proposed to mediate inhibin B antagonism of activin signaling via its type I receptor. These ideas have been challenged over the past few years. Rather than playing a role in inhibin action, IGSF1 is involved in the central control of the thyroid gland. Betaglycan binds inhibin A and inhibin B with high affinity, but only functions as an obligate inhibin A coreceptor in murine gonadotropes. There is likely to be a distinct, but currently unidentified coreceptor for inhibin B. Inhibins are gonadal hormones that suppress follicle-stimulating hormone (FSH) synthesis by pituitary gonadotrope cells. The structurally related activins stimulate FSH by signaling through complexes of type I and type II receptors. Two models of inhibin action were proposed in 2000. First, inhibins function as competitive receptor antagonists, binding activin type II receptors with high affinity in the presence of the TGF-β type III coreceptor, betaglycan. Second, immunoglobulin superfamily, member 1 (IGSF1, then called p120) was proposed to mediate inhibin B antagonism of activin signaling via its type I receptor. These ideas have been challenged over the past few years. Rather than playing a role in inhibin action, IGSF1 is involved in the central control of the thyroid gland. Betaglycan binds inhibin A and inhibin B with high affinity, but only functions as an obligate inhibin A coreceptor in murine gonadotropes. There is likely to be a distinct, but currently unidentified coreceptor for inhibin B." @default.
• W2982208564 created "2019-11-01" @default.
• W2982208564 creator A5011350239 @default.
• W2982208564 creator A5037955697 @default.
• W2982208564 creator A5060573622 @default.
• W2982208564 date "2020-01-01" @default.
• W2982208564 modified "2023-10-17" @default.
• W2982208564 title "A Tale of Two Proteins: Betaglycan, IGSF1, and the Continuing Search for the Inhibin B Receptor" @default.
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• W2982208564 doi "https://doi.org/10.1016/j.tem.2019.08.014" @default.
• W2982208564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31648935" @default.
• W2982208564 hasPublicationYear "2020" @default.
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