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• W2982209723 endingPage "108626" @default.
• W2982209723 startingPage "108626" @default.
• W2982209723 abstract "We aimed to ascertain whether ubiquitous plant-based polyphenolic flavonoid compound quercetin (Q) was capable of alleviating deltamethrin (DM) stress in a freshwater teleost, Channa punctata, with emphasis on levels of acetylcholinesterase (AChE), reduced glutathione (GSH), glutathione-S-transferase (GST), DNA/RNA contents and hematological parameters. We measured these parameters in various tissues of fish at 7 and 21 days of exposure to DM doses (0.03 and 0.15 μL L-1), Q (0.14 g L-1) and their combinations (0.03 μL DM L-1 + 0.14 g Q L-1 and 0.15 μL DM L-1 + 0.14 g Q L-1). Both the DM doses altered blood parameters, lowered DNA/RNA contents, AchE activities, GSH levels and augmented GST activities as a mark of neurotoxicity and oxidative stress in fish tissues. We found that 0.14 g L-1 Q ameliorated oxidative stress and AchE inhibitory effects, recovered DM-induced nucleic acid damage and alterations in blood parameters, with some tissue specificity and in duration-dependent manner. Thus, the results indicated that Q was capable of neuroprotection and enhancing the function of antioxidants in fish, which could be predicted to be useful for providing better protection to fish under aquaculture settings with improved Q-rich diets. Through this study with multiple biomarkers in several tissues of fish, valuable information for devising better strategies regarding pesticide risk assessment was obtained and it was recognized that an appropriate dose of Q was essential for its better functioning." @default.
• W2982209723 created "2019-11-01" @default.
• W2982209723 creator A5045192869 @default.
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• W2982209723 date "2020-01-01" @default.
• W2982209723 modified "2023-10-15" @default.
• W2982209723 title "Quercetin-induced amelioration of deltamethrin stress in freshwater teleost, Channa punctata: Multiple biomarker analysis" @default.
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• W2982209723 doi "https://doi.org/10.1016/j.cbpc.2019.108626" @default.
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• W2982209723 hasPublicationYear "2020" @default.
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