Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982287768> ?p ?o ?g. }
- W2982287768 startingPage "823351" @default.
- W2982287768 abstract "The vertebrate splicing factor RBM20 (RNA Binding Motif protein 20) regulates protein isoforms important for heart development and function, with mutations in the gene linked to cardiomyopathy. Previous studies have identified the four base RNA motif UCUU as a common element in pre-mRNA targeted by RBM20. Here, we have determined the structure of the RNA Recognition Motif (RRM) domain from mouse RBM20 bound to RNA containing a UCUU sequence. The atomic details show that the RRM domain spans a larger region than initially proposed in order to interact with the complete UCUU motif, with a well-folded C-terminal helix encoded by exon 8 critical for high affinity binding. This helix only forms upon binding RNA with the final uracil, and removing the helix reduces affinity as well as specificity. We therefore find that RBM20 uses a coupled folding-binding mechanism by the C-terminal helix to specifically recognize the UCUU RNA motif." @default.
- W2982287768 created "2019-11-08" @default.
- W2982287768 creator A5069327682 @default.
- W2982287768 creator A5073292751 @default.
- W2982287768 date "2019-10-30" @default.
- W2982287768 modified "2023-09-26" @default.
- W2982287768 title "Structural basis of UCUU RNA motif recognition by splicing factor RBM20" @default.
- W2982287768 cites W190397328 @default.
- W2982287768 cites W1968776533 @default.
- W2982287768 cites W1975459052 @default.
- W2982287768 cites W1979483545 @default.
- W2982287768 cites W1981316465 @default.
- W2982287768 cites W1992121070 @default.
- W2982287768 cites W1999042389 @default.
- W2982287768 cites W2001045428 @default.
- W2982287768 cites W2001577872 @default.
- W2982287768 cites W2005704277 @default.
- W2982287768 cites W2009902564 @default.
- W2982287768 cites W2025021056 @default.
- W2982287768 cites W2028035578 @default.
- W2982287768 cites W2028556267 @default.
- W2982287768 cites W2029957363 @default.
- W2982287768 cites W2030312576 @default.
- W2982287768 cites W2032026564 @default.
- W2982287768 cites W2040388576 @default.
- W2982287768 cites W2055948653 @default.
- W2982287768 cites W2059060273 @default.
- W2982287768 cites W2059743915 @default.
- W2982287768 cites W2061892272 @default.
- W2982287768 cites W2073010269 @default.
- W2982287768 cites W2077487028 @default.
- W2982287768 cites W2086625737 @default.
- W2982287768 cites W2087578568 @default.
- W2982287768 cites W2097572021 @default.
- W2982287768 cites W2109408452 @default.
- W2982287768 cites W2114886480 @default.
- W2982287768 cites W2118496707 @default.
- W2982287768 cites W2121293808 @default.
- W2982287768 cites W2131305724 @default.
- W2982287768 cites W2135338948 @default.
- W2982287768 cites W2147826663 @default.
- W2982287768 cites W2154479185 @default.
- W2982287768 cites W2163717101 @default.
- W2982287768 cites W2168576119 @default.
- W2982287768 cites W2169821755 @default.
- W2982287768 cites W2187274171 @default.
- W2982287768 cites W2316665668 @default.
- W2982287768 cites W2376573086 @default.
- W2982287768 cites W2414628209 @default.
- W2982287768 cites W2471981404 @default.
- W2982287768 cites W2479464375 @default.
- W2982287768 cites W2496896575 @default.
- W2982287768 cites W2502591883 @default.
- W2982287768 cites W2508597987 @default.
- W2982287768 cites W2512622411 @default.
- W2982287768 cites W2531279979 @default.
- W2982287768 cites W2556833067 @default.
- W2982287768 cites W2574826385 @default.
- W2982287768 cites W2603316490 @default.
- W2982287768 cites W2733193633 @default.
- W2982287768 cites W2743195298 @default.
- W2982287768 cites W2761155644 @default.
- W2982287768 cites W276319267 @default.
- W2982287768 cites W2794040513 @default.
- W2982287768 cites W2794329695 @default.
- W2982287768 cites W2796473433 @default.
- W2982287768 cites W2806406856 @default.
- W2982287768 cites W2808452625 @default.
- W2982287768 cites W2839139552 @default.
- W2982287768 cites W2884743521 @default.
- W2982287768 cites W2901619265 @default.
- W2982287768 cites W2903343913 @default.
- W2982287768 cites W2921063092 @default.
- W2982287768 cites W2921737965 @default.
- W2982287768 cites W2927575800 @default.
- W2982287768 cites W2947279776 @default.
- W2982287768 cites W2964544488 @default.
- W2982287768 cites W2977915024 @default.
- W2982287768 cites W2980123655 @default.
- W2982287768 cites W869626853 @default.
- W2982287768 hasPublicationYear "2019" @default.
- W2982287768 type Work @default.
- W2982287768 sameAs 2982287768 @default.
- W2982287768 citedByCount "0" @default.
- W2982287768 crossrefType "component" @default.
- W2982287768 hasAuthorship W2982287768A5069327682 @default.
- W2982287768 hasAuthorship W2982287768A5073292751 @default.
- W2982287768 hasConcept C104317684 @default.
- W2982287768 hasConcept C158730165 @default.
- W2982287768 hasConcept C194583182 @default.
- W2982287768 hasConcept C36823959 @default.
- W2982287768 hasConcept C41282012 @default.
- W2982287768 hasConcept C54355233 @default.
- W2982287768 hasConcept C54458228 @default.
- W2982287768 hasConcept C67705224 @default.
- W2982287768 hasConcept C73758832 @default.
- W2982287768 hasConcept C86803240 @default.
- W2982287768 hasConceptScore W2982287768C104317684 @default.
- W2982287768 hasConceptScore W2982287768C158730165 @default.