Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982306646> ?p ?o ?g. }
- W2982306646 endingPage "144" @default.
- W2982306646 startingPage "137" @default.
- W2982306646 abstract "The introduction of omics technologies in the field of Transfusion Medicine has significantly advanced our understanding of the red cell storage lesion. While the clinical relevance of such a lesion is still a matter of debate, quantitative and redox proteomics approaches, as well quantitative metabolic flux analysis and metabolic tracing experiments promise to revolutionise our understanding of the role of blood processing strategies, inform the design and testing of novel additives or technologies (such as pathogen reduction), and evaluate the clinical relevance of donor and recipient biological variability with respect to red cell storability and transfusion outcomes. By reviewing existing literature in this rapidly expanding research endeavour, we highlight for the first time a correlation between metabolic markers of the red cell storage age and protein markers of haemolysis. Finally, we introduce the concept of metabolic linkage, i.e. the appreciation of a network of highly correlated small molecule metabolites which results from biochemical constraints of erythrocyte metabolic enzyme activities. For the foreseeable future, red cell studies will advance Transfusion Medicine and haematology by addressing the alteration of metabolic linkage phenotypes in response to stimuli, including, but not limited to, storage additives, enzymopathies (e.g. glucose 6-phosphate dehydrogenase deficiency), hypoxia, sepsis or haemorrhage." @default.
- W2982306646 created "2019-11-08" @default.
- W2982306646 creator A5004661227 @default.
- W2982306646 creator A5015893927 @default.
- W2982306646 creator A5043837910 @default.
- W2982306646 creator A5045175167 @default.
- W2982306646 creator A5076307322 @default.
- W2982306646 creator A5089380647 @default.
- W2982306646 date "2017-03-01" @default.
- W2982306646 modified "2023-10-12" @default.
- W2982306646 title "Omics markers of the red cell storage lesion and metabolic linkage." @default.
- W2982306646 cites W1491559148 @default.
- W2982306646 cites W1551870152 @default.
- W2982306646 cites W1661767063 @default.
- W2982306646 cites W1740510078 @default.
- W2982306646 cites W1769761307 @default.
- W2982306646 cites W1774708905 @default.
- W2982306646 cites W1906054947 @default.
- W2982306646 cites W1923295116 @default.
- W2982306646 cites W1946741439 @default.
- W2982306646 cites W1953229729 @default.
- W2982306646 cites W1967872106 @default.
- W2982306646 cites W1986063899 @default.
- W2982306646 cites W1991036755 @default.
- W2982306646 cites W1992458520 @default.
- W2982306646 cites W2004260172 @default.
- W2982306646 cites W2013291317 @default.
- W2982306646 cites W2013396763 @default.
- W2982306646 cites W2014128154 @default.
- W2982306646 cites W2019578556 @default.
- W2982306646 cites W2028790836 @default.
- W2982306646 cites W2029325498 @default.
- W2982306646 cites W2031898405 @default.
- W2982306646 cites W2035934312 @default.
- W2982306646 cites W2053253045 @default.
- W2982306646 cites W2067520432 @default.
- W2982306646 cites W2072784013 @default.
- W2982306646 cites W2076918218 @default.
- W2982306646 cites W2080554678 @default.
- W2982306646 cites W2081305693 @default.
- W2982306646 cites W2086312820 @default.
- W2982306646 cites W2091932154 @default.
- W2982306646 cites W2096838691 @default.
- W2982306646 cites W2107921622 @default.
- W2982306646 cites W2150319414 @default.
- W2982306646 cites W2151125432 @default.
- W2982306646 cites W2152798740 @default.
- W2982306646 cites W2153986322 @default.
- W2982306646 cites W2154717205 @default.
- W2982306646 cites W2157081117 @default.
- W2982306646 cites W2158469084 @default.
- W2982306646 cites W2161765652 @default.
- W2982306646 cites W2161889928 @default.
- W2982306646 cites W2186442135 @default.
- W2982306646 cites W2194318288 @default.
- W2982306646 cites W2210974969 @default.
- W2982306646 cites W2213908726 @default.
- W2982306646 cites W2235759113 @default.
- W2982306646 cites W2266985620 @default.
- W2982306646 cites W2295035322 @default.
- W2982306646 cites W2302309315 @default.
- W2982306646 cites W2326550413 @default.
- W2982306646 cites W2327399609 @default.
- W2982306646 cites W2336431840 @default.
- W2982306646 cites W2338022308 @default.
- W2982306646 cites W2338391427 @default.
- W2982306646 cites W2341784617 @default.
- W2982306646 cites W2461866271 @default.
- W2982306646 cites W2466448487 @default.
- W2982306646 cites W2470296430 @default.
- W2982306646 cites W2478479849 @default.
- W2982306646 cites W2495368724 @default.
- W2982306646 cites W2507939969 @default.
- W2982306646 cites W2515863781 @default.
- W2982306646 cites W2523108916 @default.
- W2982306646 cites W2523325624 @default.
- W2982306646 cites W2523514874 @default.
- W2982306646 cites W2531750597 @default.
- W2982306646 cites W2534404687 @default.
- W2982306646 cites W2548952244 @default.
- W2982306646 cites W3025291272 @default.
- W2982306646 cites W56333112 @default.
- W2982306646 cites W639896132 @default.
- W2982306646 doi "https://doi.org/10.2450/2017.0341-16" @default.
- W2982306646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5336335" @default.
- W2982306646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28263171" @default.
- W2982306646 hasPublicationYear "2017" @default.
- W2982306646 type Work @default.
- W2982306646 sameAs 2982306646 @default.
- W2982306646 citedByCount "17" @default.
- W2982306646 countsByYear W29823066462017 @default.
- W2982306646 countsByYear W29823066462018 @default.
- W2982306646 countsByYear W29823066462019 @default.
- W2982306646 countsByYear W29823066462020 @default.
- W2982306646 countsByYear W29823066462021 @default.
- W2982306646 countsByYear W29823066462022 @default.
- W2982306646 countsByYear W29823066462023 @default.
- W2982306646 crossrefType "journal-article" @default.