FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982324039> ?p ?o ?g. }

• W2982324039 endingPage "8343" @default.
• W2982324039 startingPage "8332" @default.
• W2982324039 abstract "Rationale: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a co-inhibitory checkpoint receptor that is expressed by naïve T-cells in lymph nodes (LNs) to inhibit activation against self antigens (Ags). In cancer, anti-CTLA-4 blocks inhibitory action, enabling robust activation of T-cells against tumor Ags presented in tumor draining LNs (TDLNs). However, anti-CTLA-4 is administered intravenously with limited exposure within TDLNs and immune related adverse events (irAEs) are associated with over-stimulation of the immune system. Methods: Herein, we first deliver anti-CTLA-4 in an orthotopic mammary carcinoma murine model using a nanotopographical microneedle-array device to compare its anti-tumor response to that from systemic administration. Additionally, to demonstrate the feasibility of lymphatic delivery in humans using the device, we use near-infrared fluorescence imaging to image delivery of ICG to LNs. Results: Our data show that lymphatic infusion results in more effective tumor growth inhibition, arrest of metastases, increased tumor infiltrating lymphocytes and complete responses when compared to conventional systemic administration. In clinical studies, we demonstrate for the first time that nanotopographic infusion can deliver ICG through the lymphatics directly to the axilla and inguinal LNs of healthy human volunteers. Conclusion: Taken together, these results suggest that regional delivery using a nanotopography-based microneedle array could revolutionize checkpoint blockade immunotherapy by reducing systemic drug exposure and maximizing drug delivery to TDLNs where tumor Ags present. Future work is needed to determine whether lymphatic delivery of anti-CTLA-4 can alleviate irAEs that occur with systemic dosing." @default.
• W2982324039 created "2019-11-08" @default.
• W2982324039 creator A5008862630 @default.
• W2982324039 creator A5010040593 @default.
• W2982324039 creator A5024566503 @default.
• W2982324039 creator A5025179117 @default.
• W2982324039 creator A5025182463 @default.
• W2982324039 creator A5044314141 @default.
• W2982324039 creator A5047875201 @default.
• W2982324039 creator A5081948783 @default.
• W2982324039 creator A5083885715 @default.
• W2982324039 creator A5088469510 @default.
• W2982324039 date "2019-01-01" @default.
• W2982324039 modified "2023-09-27" @default.
• W2982324039 title "Nanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy" @default.
• W2982324039 cites W1914776013 @default.
• W2982324039 cites W1978354618 @default.
• W2982324039 cites W1986985221 @default.
• W2982324039 cites W1999587028 @default.
• W2982324039 cites W2005886529 @default.
• W2982324039 cites W2017509574 @default.
• W2982324039 cites W2026861011 @default.
• W2982324039 cites W2028056617 @default.
• W2982324039 cites W2030194771 @default.
• W2982324039 cites W2041153276 @default.
• W2982324039 cites W2054512362 @default.
• W2982324039 cites W2057377546 @default.
• W2982324039 cites W2066671159 @default.
• W2982324039 cites W2070044081 @default.
• W2982324039 cites W2096751726 @default.
• W2982324039 cites W2099199155 @default.
• W2982324039 cites W2118012186 @default.
• W2982324039 cites W2121080857 @default.
• W2982324039 cites W2128758225 @default.
• W2982324039 cites W2131280878 @default.
• W2982324039 cites W2132002483 @default.
• W2982324039 cites W2142767975 @default.
• W2982324039 cites W2152897456 @default.
• W2982324039 cites W2166662937 @default.
• W2982324039 cites W2194632500 @default.
• W2982324039 cites W2308809093 @default.
• W2982324039 cites W2347141054 @default.
• W2982324039 cites W2516619560 @default.
• W2982324039 cites W2517633617 @default.
• W2982324039 cites W2560367415 @default.
• W2982324039 cites W2572174216 @default.
• W2982324039 cites W2594529508 @default.
• W2982324039 cites W2618355283 @default.
• W2982324039 cites W2618889580 @default.
• W2982324039 cites W2761875085 @default.
• W2982324039 cites W2768778626 @default.
• W2982324039 cites W2788206402 @default.
• W2982324039 cites W2808318674 @default.
• W2982324039 cites W2902489593 @default.
• W2982324039 cites W2912137299 @default.
• W2982324039 cites W795187413 @default.
• W2982324039 doi "https://doi.org/10.7150/thno.35280" @default.
• W2982324039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6857054" @default.
• W2982324039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31754400" @default.
• W2982324039 hasPublicationYear "2019" @default.
• W2982324039 type Work @default.
• W2982324039 sameAs 2982324039 @default.
• W2982324039 citedByCount "28" @default.
• W2982324039 countsByYear W29823240392020 @default.
• W2982324039 countsByYear W29823240392021 @default.
• W2982324039 countsByYear W29823240392022 @default.
• W2982324039 countsByYear W29823240392023 @default.
• W2982324039 crossrefType "journal-article" @default.
• W2982324039 hasAuthorship W2982324039A5008862630 @default.
• W2982324039 hasAuthorship W2982324039A5010040593 @default.
• W2982324039 hasAuthorship W2982324039A5024566503 @default.
• W2982324039 hasAuthorship W2982324039A5025179117 @default.
• W2982324039 hasAuthorship W2982324039A5025182463 @default.
• W2982324039 hasAuthorship W2982324039A5044314141 @default.
• W2982324039 hasAuthorship W2982324039A5047875201 @default.
• W2982324039 hasAuthorship W2982324039A5081948783 @default.
• W2982324039 hasAuthorship W2982324039A5083885715 @default.
• W2982324039 hasAuthorship W2982324039A5088469510 @default.
• W2982324039 hasBestOaLocation W29823240391 @default.
• W2982324039 hasConcept C154317977 @default.
• W2982324039 hasConcept C181152851 @default.
• W2982324039 hasConcept C185592680 @default.
• W2982324039 hasConcept C202751555 @default.
• W2982324039 hasConcept C203014093 @default.
• W2982324039 hasConcept C2777701055 @default.
• W2982324039 hasConcept C2780674031 @default.
• W2982324039 hasConcept C2780851360 @default.
• W2982324039 hasConcept C502942594 @default.
• W2982324039 hasConcept C55493867 @default.
• W2982324039 hasConcept C71924100 @default.
• W2982324039 hasConcept C8891405 @default.
• W2982324039 hasConcept C98274493 @default.
• W2982324039 hasConceptScore W2982324039C154317977 @default.
• W2982324039 hasConceptScore W2982324039C181152851 @default.
• W2982324039 hasConceptScore W2982324039C185592680 @default.
• W2982324039 hasConceptScore W2982324039C202751555 @default.
• W2982324039 hasConceptScore W2982324039C203014093 @default.
• W2982324039 hasConceptScore W2982324039C2777701055 @default.

• next