Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982328716> ?p ?o ?g. }
- W2982328716 endingPage "1347" @default.
- W2982328716 startingPage "1347" @default.
- W2982328716 abstract "Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows efficiency and fidelity in protein production. Among the actors involved in such process, both endoplasmic reticulum (ER) and the Golgi complex play prominent roles in protein synthesis, biogenesis and secretion. ER and Golgi functions ensure that only properly folded proteins are allowed to flow through the secretory pathway while improperly folded proteins have to be eliminated to not impinge on cellular functions. Thus, complex quality control and degradation machineries are crucial to prevent the toxic accumulation of improperly folded proteins. However, in some instances, improperly folded proteins can escape the quality control systems thereby contributing to several human diseases. Herein, we summarize how the early secretory pathways copes with the accumulation of improperly folded proteins, and how insufficient handling can cause the development of several human diseases. Finally, we detail the genetic and pharmacologic approaches that could be used as potential therapeutic tools to treat these diseases." @default.
- W2982328716 created "2019-11-08" @default.
- W2982328716 creator A5008335096 @default.
- W2982328716 creator A5010379832 @default.
- W2982328716 creator A5061057486 @default.
- W2982328716 date "2019-10-29" @default.
- W2982328716 modified "2023-10-13" @default.
- W2982328716 title "Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges" @default.
- W2982328716 cites W1522290843 @default.
- W2982328716 cites W1575156763 @default.
- W2982328716 cites W1790175734 @default.
- W2982328716 cites W1924112666 @default.
- W2982328716 cites W1942783244 @default.
- W2982328716 cites W1946268637 @default.
- W2982328716 cites W1965727325 @default.
- W2982328716 cites W1969312560 @default.
- W2982328716 cites W1969511823 @default.
- W2982328716 cites W1971442774 @default.
- W2982328716 cites W1972385206 @default.
- W2982328716 cites W1974191631 @default.
- W2982328716 cites W1974256456 @default.
- W2982328716 cites W1977603207 @default.
- W2982328716 cites W1979733074 @default.
- W2982328716 cites W1980153386 @default.
- W2982328716 cites W1981551685 @default.
- W2982328716 cites W1981643083 @default.
- W2982328716 cites W1984547206 @default.
- W2982328716 cites W1990057935 @default.
- W2982328716 cites W1990607211 @default.
- W2982328716 cites W1991942986 @default.
- W2982328716 cites W1993401552 @default.
- W2982328716 cites W1994772574 @default.
- W2982328716 cites W1995492325 @default.
- W2982328716 cites W1998626286 @default.
- W2982328716 cites W2002034658 @default.
- W2982328716 cites W2003755766 @default.
- W2982328716 cites W2008801986 @default.
- W2982328716 cites W2011714134 @default.
- W2982328716 cites W2012265138 @default.
- W2982328716 cites W2013996883 @default.
- W2982328716 cites W2015313755 @default.
- W2982328716 cites W2015902113 @default.
- W2982328716 cites W2015944321 @default.
- W2982328716 cites W2016013331 @default.
- W2982328716 cites W2017934344 @default.
- W2982328716 cites W2022087931 @default.
- W2982328716 cites W2024103451 @default.
- W2982328716 cites W2024679573 @default.
- W2982328716 cites W2025511820 @default.
- W2982328716 cites W2029458552 @default.
- W2982328716 cites W2031735388 @default.
- W2982328716 cites W2036677133 @default.
- W2982328716 cites W2037683893 @default.
- W2982328716 cites W2041529568 @default.
- W2982328716 cites W2046063066 @default.
- W2982328716 cites W2046755890 @default.
- W2982328716 cites W2048086508 @default.
- W2982328716 cites W2048165620 @default.
- W2982328716 cites W2050963438 @default.
- W2982328716 cites W2061774676 @default.
- W2982328716 cites W2066557401 @default.
- W2982328716 cites W2069482173 @default.
- W2982328716 cites W2071046609 @default.
- W2982328716 cites W2073727172 @default.
- W2982328716 cites W2085580153 @default.
- W2982328716 cites W2090157168 @default.
- W2982328716 cites W2092645001 @default.
- W2982328716 cites W2094372926 @default.
- W2982328716 cites W2104988047 @default.
- W2982328716 cites W2115205812 @default.
- W2982328716 cites W2117481030 @default.
- W2982328716 cites W2120736516 @default.
- W2982328716 cites W2121039852 @default.
- W2982328716 cites W2127419185 @default.
- W2982328716 cites W2130092335 @default.
- W2982328716 cites W2133644385 @default.
- W2982328716 cites W2137559379 @default.
- W2982328716 cites W2139568257 @default.
- W2982328716 cites W2140671259 @default.
- W2982328716 cites W2145094996 @default.
- W2982328716 cites W2145844162 @default.
- W2982328716 cites W2147336345 @default.
- W2982328716 cites W2148142792 @default.
- W2982328716 cites W2150555063 @default.
- W2982328716 cites W2152578203 @default.
- W2982328716 cites W2154500525 @default.
- W2982328716 cites W2155837155 @default.
- W2982328716 cites W2156576736 @default.
- W2982328716 cites W2156739666 @default.
- W2982328716 cites W2158930854 @default.
- W2982328716 cites W2169445756 @default.
- W2982328716 cites W2170939329 @default.
- W2982328716 cites W2171878310 @default.
- W2982328716 cites W2188189858 @default.
- W2982328716 cites W2192080449 @default.
- W2982328716 cites W2288642608 @default.
- W2982328716 cites W2292633092 @default.
- W2982328716 cites W2310305711 @default.