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• W2982334843 abstract "Abstract A common feature shared by systemic fungal pathogens of environmental origin, such as Cryptococcus neoformans , is their ability to adapt to mammalian core body temperature. In C. neoformans , this adaptation is accompanied by Ccr4-mediated decay of ribosomal protein mRNAs. Here we use the related, but thermo-intolerant species Cryptococcus amylolentus to demonstrate that this response contributes to host-temperature adaptation and pathogenicity of cryptococci. In a C. neoformans ccr4 Δ mutant, stabilized ribosomal protein mRNAs are retained in the translating pool, and stress-induced transcriptomic changes are reduced in comparison with the wild type strain, likely due to ineffective translation of transcription factors. In addition, the mutant displays increased exposure of cell wall glucans, and recognition by Dectin-1 results in increased phagocytosis by lung macrophages, linking mRNA decay to adaptation and immune evasion." @default.
• W2982334843 created "2019-11-08" @default.
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• W2982334843 date "2019-10-30" @default.
• W2982334843 modified "2023-10-06" @default.
• W2982334843 title "Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming" @default.
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• W2982334843 doi "https://doi.org/10.1038/s41467-019-12907-x" @default.
• W2982334843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6821889" @default.
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