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• W2982372904 abstract "Abstract AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays a pivotal role in the proliferation of AE-expressing acute myeloid leukemia (AML) cells. ChIP-sequencing indicates significant overlap of the TAF1 and AE binding sites. Knockdown of TAF1 alters the association of AE with chromatin, affecting of the expression of genes that are activated or repressed by AE. Furthermore, TAF1 is required for leukemic cell self-renewal and its reduction promotes the differentiation and apoptosis of AE+ AML cells, thereby impairing AE driven leukemogenesis. Together, our findings reveal a role of TAF1 in leukemogenesis and identify TAF1 as a potential therapeutic target for AE-expressing leukemia." @default.
• W2982372904 created "2019-11-08" @default.
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• W2982372904 date "2019-10-29" @default.
• W2982372904 modified "2023-10-14" @default.
• W2982372904 title "TAF1 plays a critical role in AML1-ETO driven leukemogenesis" @default.
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• W2982372904 doi "https://doi.org/10.1038/s41467-019-12735-z" @default.
• W2982372904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6820555" @default.
• W2982372904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31664040" @default.
• W2982372904 hasPublicationYear "2019" @default.
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