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- W2982375778 abstract "Chronic nonbacterial osteomyelitis (CNO) is a rare inflammatory disorder that primarily affects children. It is characterized by insidious onset of pain, local bone expansion, and radiological findings suggestive of osteomyelitis, usually at multiple sites. CNO predominantly affects metaphyses of long bones, but clavicle and mandible are suggestive of diagnosis. CNO is a diagnosis of exclusion, and its pathogenesis is still unknown. Differential diagnosis includes infections, malignancies, benign bone tumors, metabolic disorders, and other autoinflammatory disorders. Biopsy of the bone lesion is often required. Nonsteroidal anti-inflammatory drugs are the first choice of treatment. Alternative therapies have been used, including corticosteroids, methotrexate, bisphosphonates, and TNFα inhibitors. No guidelines exist on diagnostic and treatment options." @default.
- W2982375778 created "2019-11-08" @default.
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- W2982375778 date "2019-10-30" @default.
- W2982375778 modified "2023-10-18" @default.
- W2982375778 title "Chronic Nonbacterial Osteomyelitis" @default.
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- W2982375778 doi "https://doi.org/10.1007/978-3-030-19055-2_8" @default.
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