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• W2982399071 abstract "Platelets are abundant, small, anucleate circulating cells, serving many emerging pathophysiological roles beyond hemostasis; including active critical roles in thrombosis, injury response, and immunoregulation. In the absence of genomic DNA transcriptional regulation (no nucleus), platelets require strategic prepackaging of all the needed RNA and organelles from megakaryocytes, to sense stress (e.g., hyperglycemia), to protect themselves from stress (e.g., mitophagy), and to communicate a stress response to other cells (e.g., granule and microparticle release). Distinct from avian thrombocytes that have a nucleus, the absence of a nucleus allows the mammalian platelet to maintain its small size, permits morphological flexibility, and may improve speed and efficiency of protein expression in response to stress. In the absence of a nucleus, platelet lifespan of 7-10 days, is largely determined by the mitochondria. The packaging of 5-8 mitochondria is critical in aerobic respiration and yielding metabolic substrates needed for function and survival. Mitochondria damage or dysfunction, as observed with several disease processes, results in greatly attenuated platelet survival and increased risk for thrombovascular events. Here we provide insights into the emerging roles of platelets despite the lack of a nucleus, and the key role played by mitochondria in platelet function and survival both in health and disease." @default.
• W2982399071 created "2019-11-08" @default.
• W2982399071 creator A5057266958 @default.
• W2982399071 creator A5063635199 @default.
• W2982399071 creator A5067199373 @default.
• W2982399071 creator A5077834308 @default.
• W2982399071 date "2019-10-29" @default.
• W2982399071 modified "2023-10-18" @default.
• W2982399071 title "Role of Platelet Mitochondria: Life in a Nucleus-Free Zone" @default.
• W2982399071 cites W111889214 @default.
• W2982399071 cites W1243053831 @default.
• W2982399071 cites W1486139564 @default.
• W2982399071 cites W1493157894 @default.
• W2982399071 cites W1501599308 @default.
• W2982399071 cites W1518489158 @default.
• W2982399071 cites W1523693806 @default.
• W2982399071 cites W1536258113 @default.
• W2982399071 cites W1543787350 @default.
• W2982399071 cites W154881089 @default.
• W2982399071 cites W1569904835 @default.
• W2982399071 cites W1588992136 @default.
• W2982399071 cites W1605478240 @default.
• W2982399071 cites W1738348680 @default.
• W2982399071 cites W1757310287 @default.
• W2982399071 cites W1770535374 @default.
• W2982399071 cites W1880092164 @default.
• W2982399071 cites W190415036 @default.
• W2982399071 cites W1964215335 @default.
• W2982399071 cites W1964548815 @default.
• W2982399071 cites W1967474532 @default.
• W2982399071 cites W1968089064 @default.
• W2982399071 cites W1968949305 @default.
• W2982399071 cites W1969364921 @default.
• W2982399071 cites W1974696668 @default.
• W2982399071 cites W1976954262 @default.
• W2982399071 cites W1977258127 @default.
• W2982399071 cites W1979279686 @default.
• W2982399071 cites W1982235280 @default.
• W2982399071 cites W1984887826 @default.
• W2982399071 cites W1986229742 @default.
• W2982399071 cites W1987769185 @default.
• W2982399071 cites W1988288321 @default.
• W2982399071 cites W1990341278 @default.
• W2982399071 cites W1993525245 @default.
• W2982399071 cites W1995326741 @default.
• W2982399071 cites W1995579230 @default.
• W2982399071 cites W1997153826 @default.
• W2982399071 cites W1998100237 @default.
• W2982399071 cites W1998599956 @default.
• W2982399071 cites W2000296467 @default.
• W2982399071 cites W2001699624 @default.
• W2982399071 cites W2005005084 @default.
• W2982399071 cites W2005045122 @default.
• W2982399071 cites W2005073515 @default.
• W2982399071 cites W2006447143 @default.
• W2982399071 cites W2006944986 @default.
• W2982399071 cites W2015230474 @default.
• W2982399071 cites W2016040396 @default.
• W2982399071 cites W2016236015 @default.
• W2982399071 cites W2018036144 @default.
• W2982399071 cites W2021754558 @default.
• W2982399071 cites W2022164794 @default.
• W2982399071 cites W2022566551 @default.
• W2982399071 cites W2024865584 @default.
• W2982399071 cites W2029064649 @default.
• W2982399071 cites W2032913442 @default.
• W2982399071 cites W2033085746 @default.
• W2982399071 cites W2034087770 @default.
• W2982399071 cites W2035062284 @default.
• W2982399071 cites W2039640090 @default.
• W2982399071 cites W2042103669 @default.
• W2982399071 cites W2042122319 @default.
• W2982399071 cites W2042888704 @default.
• W2982399071 cites W2043276141 @default.
• W2982399071 cites W2044979779 @default.
• W2982399071 cites W2045338741 @default.
• W2982399071 cites W2050711948 @default.
• W2982399071 cites W2050808293 @default.
• W2982399071 cites W2055599313 @default.
• W2982399071 cites W2057585285 @default.
• W2982399071 cites W2058217708 @default.
• W2982399071 cites W2061266262 @default.
• W2982399071 cites W2062892961 @default.
• W2982399071 cites W2065721484 @default.
• W2982399071 cites W2066746672 @default.
• W2982399071 cites W2068700852 @default.
• W2982399071 cites W2079375831 @default.
• W2982399071 cites W2080485793 @default.
• W2982399071 cites W2082273479 @default.
• W2982399071 cites W2082460299 @default.
• W2982399071 cites W2082924906 @default.
• W2982399071 cites W2084983272 @default.
• W2982399071 cites W2085419794 @default.
• W2982399071 cites W2087377067 @default.
• W2982399071 cites W2090407616 @default.
• W2982399071 cites W2096468633 @default.
• W2982399071 cites W2096564024 @default.
• W2982399071 cites W2097704104 @default.
• W2982399071 cites W2103398208 @default.
• W2982399071 cites W2104998148 @default.

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