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• W2982400650 abstract "The cell cortex, a thin film of active material assembled below the cell membrane, plays a key role in cellular symmetry-breaking processes such as cell polarity establishment and cell division. Here, we present a minimal model of the self-organization of the cell cortex that is based on a hydrodynamic theory of curved active surfaces. Active stresses on this surface are regulated by a diffusing molecular species. We show that coupling of the active surface to a passive bulk fluid enables spontaneous polarization and the formation of a contractile ring on the surface via mechanochemical instabilities. We discuss the role of external fields in guiding such pattern formation. Our work reveals that key features of cellular symmetry breaking and cell division can emerge in a minimal model via general dynamic instabilities." @default.
• W2982400650 created "2019-11-08" @default.
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• W2982400650 date "2019-10-28" @default.
• W2982400650 modified "2023-10-18" @default.
• W2982400650 title "Minimal Model of Cellular Symmetry Breaking" @default.
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• W2982400650 doi "https://doi.org/10.1103/physrevlett.123.188101" @default.
• W2982400650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31763902" @default.
• W2982400650 hasPublicationYear "2019" @default.
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