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• W2982445462 abstract "•HDL-CEC is not associated with subclinical or clinical atherosclerosis •HDL-C, apoA-I, HDL size, and HDL-P show atheroprotective associations •Atheroprotective associations of HDL-size and HDL-P are lost with (pre)diabetes Background Cholesterol Efflux Capacity (CEC) is considered to be a key atheroprotective property of high-density lipoproteins (HDL). However, the role of HDL-CEC in atherosclerosis and cardiovascular (CV) risk is still controversial, and data in individuals with diabetes are limited. Objective In this study, we have investigated the relationship of CEC and other HDL characteristics with clinical and subclinical atherosclerosis in subjects with elevated cardiovascular diseases (CVD) risk and Type 2 Diabetes Mellitus (T2DM). Methods Using multiple linear regression analyses, we determined the relationship of HDL-CEC with carotid intima-media thickness (cIMT, Z-Score), an endothelial dysfunction (EnD) Score (Z-Score), prevalent CVD (n = 150 cases) and history of CV events (CVE, n = 85 cases) in an observational cohort (CODAM, n = 574, 59.6 ± 0.3 yr, 61.3% men, 24.4% T2DM). Stratified analyses were performed to determine if the associations differed between individuals with normal glucose metabolism (NGM) and those with disturbed glucose metabolism. Results HDL-CEC was not associated with either marker of atherosclerosis (cIMT, EnD Score) nor with CVD or CVE. In contrast, other HDL characteristics that is, HDL-Cholesterol (HDL-C, Z-Score), apolipoprotein A-I (apoA-I, Z-Score), HDL size (Z-Score) and HDL particle number (HDL-P, Z-Score) were inversely and significantly associated with the EnD Score (s −0.226 to −0.097, P < .05) and CVE (ORs 0.61 to 0.68, P < .05). In stratified analyses, HDL size and HDL-P were significantly associated with the EnD Score in individuals with NGM (Pinteraction .039 and .005, respectively), but not in those with (pre)diabetes. HDL-C and apoA-I were inversely associated with prevalent CVD in individuals with (pre)diabetes (Pinteraction = .074 and .034, respectively), but not in those with NGM. Conclusion HDL-CEC is not associated with clinical or subclinical atherosclerosis, neither in the whole population nor in individuals with (pre)diabetes, while other HDL characteristics show atheroprotective associations. The atheroprotective associations of HDL-size and HDL-P are lost in (pre)diabetes, while higher concentrations of HDL-C and apoA-I are associated with a lower prevalence of CVD in (pre)diabetes. Cholesterol Efflux Capacity (CEC) is considered to be a key atheroprotective property of high-density lipoproteins (HDL). However, the role of HDL-CEC in atherosclerosis and cardiovascular (CV) risk is still controversial, and data in individuals with diabetes are limited. In this study, we have investigated the relationship of CEC and other HDL characteristics with clinical and subclinical atherosclerosis in subjects with elevated cardiovascular diseases (CVD) risk and Type 2 Diabetes Mellitus (T2DM). Using multiple linear regression analyses, we determined the relationship of HDL-CEC with carotid intima-media thickness (cIMT, Z-Score), an endothelial dysfunction (EnD) Score (Z-Score), prevalent CVD (n = 150 cases) and history of CV events (CVE, n = 85 cases) in an observational cohort (CODAM, n = 574, 59.6 ± 0.3 yr, 61.3% men, 24.4% T2DM). Stratified analyses were performed to determine if the associations differed between individuals with normal glucose metabolism (NGM) and those with disturbed glucose metabolism. HDL-CEC was not associated with either marker of atherosclerosis (cIMT, EnD Score) nor with CVD or CVE. In contrast, other HDL characteristics that is, HDL-Cholesterol (HDL-C, Z-Score), apolipoprotein A-I (apoA-I, Z-Score), HDL size (Z-Score) and HDL particle number (HDL-P, Z-Score) were inversely and significantly associated with the EnD Score (s −0.226 to −0.097, P < .05) and CVE (ORs 0.61 to 0.68, P < .05). In stratified analyses, HDL size and HDL-P were significantly associated with the EnD Score in individuals with NGM (Pinteraction .039 and .005, respectively), but not in those with (pre)diabetes. HDL-C and apoA-I were inversely associated with prevalent CVD in individuals with (pre)diabetes (Pinteraction = .074 and .034, respectively), but not in those with NGM. HDL-CEC is not associated with clinical or subclinical atherosclerosis, neither in the whole population nor in individuals with (pre)diabetes, while other HDL characteristics show atheroprotective associations. The atheroprotective associations of HDL-size and HDL-P are lost in (pre)diabetes, while higher concentrations of HDL-C and apoA-I are associated with a lower prevalence of CVD in (pre)diabetes." @default.
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• W2982445462 date "2020-01-01" @default.
• W2982445462 modified "2023-10-01" @default.
• W2982445462 title "High-density lipoprotein cholesterol efflux capacity is not associated with atherosclerosis and prevalence of cardiovascular outcome: The CODAM study" @default.
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• W2982445462 cites W1856460279 @default.
• W2982445462 cites W1892706622 @default.
• W2982445462 cites W1969608946 @default.
• W2982445462 cites W1973355122 @default.
• W2982445462 cites W1977843793 @default.
• W2982445462 cites W1983286979 @default.
• W2982445462 cites W1995326828 @default.
• W2982445462 cites W1997622491 @default.
• W2982445462 cites W2006921001 @default.
• W2982445462 cites W2008069817 @default.
• W2982445462 cites W2021309429 @default.
• W2982445462 cites W2025603411 @default.
• W2982445462 cites W2026256810 @default.
• W2982445462 cites W2028943130 @default.
• W2982445462 cites W2037669982 @default.
• W2982445462 cites W2040229500 @default.
• W2982445462 cites W2048760408 @default.
• W2982445462 cites W2055823448 @default.
• W2982445462 cites W2058668210 @default.
• W2982445462 cites W2060453932 @default.
• W2982445462 cites W2062848808 @default.
• W2982445462 cites W2064707131 @default.
• W2982445462 cites W2071884718 @default.
• W2982445462 cites W2079872656 @default.
• W2982445462 cites W2086220242 @default.
• W2982445462 cites W2094768566 @default.
• W2982445462 cites W2098290541 @default.
• W2982445462 cites W2099733654 @default.
• W2982445462 cites W2100791808 @default.
• W2982445462 cites W2102421441 @default.
• W2982445462 cites W2109429564 @default.
• W2982445462 cites W2113504642 @default.
• W2982445462 cites W2115914704 @default.
• W2982445462 cites W2125836552 @default.
• W2982445462 cites W2127260850 @default.
• W2982445462 cites W2129126919 @default.
• W2982445462 cites W2133990668 @default.
• W2982445462 cites W2134075852 @default.
• W2982445462 cites W2137731766 @default.
• W2982445462 cites W2141036185 @default.
• W2982445462 cites W2146509235 @default.
• W2982445462 cites W2147663252 @default.
• W2982445462 cites W2150325684 @default.
• W2982445462 cites W2151736987 @default.
• W2982445462 cites W2155110384 @default.
• W2982445462 cites W2158057499 @default.
• W2982445462 cites W2161407352 @default.
• W2982445462 cites W2165296932 @default.
• W2982445462 cites W2169765700 @default.
• W2982445462 cites W2175680864 @default.
• W2982445462 cites W2218134106 @default.
• W2982445462 cites W2273474388 @default.
• W2982445462 cites W2301002197 @default.
• W2982445462 cites W2321455953 @default.
• W2982445462 cites W2413576220 @default.
• W2982445462 cites W2415768035 @default.
• W2982445462 cites W2544689233 @default.
• W2982445462 cites W2555385098 @default.
• W2982445462 cites W2563927291 @default.
• W2982445462 cites W2587991149 @default.
• W2982445462 cites W2736722877 @default.
• W2982445462 cites W2795785751 @default.
• W2982445462 cites W2817166195 @default.
• W2982445462 cites W2898140812 @default.
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• W2982445462 doi "https://doi.org/10.1016/j.jacl.2019.10.012" @default.
• W2982445462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8176544" @default.
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• W2982445462 hasPublicationYear "2020" @default.
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