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- W2982475198 abstract "Aim: Identification of new anticancer glycosidic derivatives of podophyllotoxin. Methods: 14 podophyllotoxin D- and L-monosaccharides have been synthesized in three steps employing de novo glycosylation strategy, and their abilities to inhibit the growth of HeLa, HepG2, MCF-7, A549 and MDA-MB-231 cancer cells were investigated by MTT assay. Molecular docking study of compound 5j with tubulin was performed. Immunofluorescence was applied for detecting the inhibitory effect of 5j on tubulin polymerization. Results & conclusion: Most of synthesized compounds showed strong cytotoxicity activity against five cancer cell lines. Compound 5j possessed the highest cytotoxicity with the IC 50 values from 41.6 to 95.2 nM, and could concentration-dependently inhibit polymerization of the microtubule cytoskeleton of MCF-7 cells. Molecular docking disclosed that sugar moiety-dedicated hydrogen bond endowed 5j a higher binding affinity for tubulin." @default.
- W2982475198 created "2019-11-08" @default.
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- W2982475198 date "2019-12-01" @default.
- W2982475198 modified "2023-09-26" @default.
- W2982475198 title "Divergent <i>de novo</i> synthesis of 2,4,5-trideoxyhexopyranosides derivatives of podophyllotoxin as anticancer agents" @default.
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- W2982475198 doi "https://doi.org/10.4155/fmc-2018-0593" @default.
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