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• W2982508715 abstract "Abstract Objectives To evaluate the effect of an antimicrobial stewardship programme in two intensive care units (ICUs) of a teaching hospital. Methods Between January 2017 and June 2018 we conducted a prospective, interventional, interrupted time-series study, based on Prospective Audit and Feedback in two ICUs of an acute-care teaching hospital. The primary outcomes were the difference in the antibiotic consumption, and the incidence of bloodstream infections (BSI) caused by multidrug-resistant (MDR) organisms. The secondary outcomes included the hospital mortality rate, the mean length of stay and the antibiotic expense. Results During the study, 231 audits were performed, evaluating 693 antibiotic prescriptions. The programme led to a global reduction in antibiotic consumption, with a change in level (CL) of –324.8 defined daily doses (DDD)/100 patient-days (PD), p 0.04, and particularly in the use of fluoroquinolone: (CL: –63.48 DDD/100 PD, p  Conclusions Our study demonstrated that implementation of an antimicrobial stewardship programme in two ICUs of a teaching hospital induced a significant reduction in antibiotic consumption and in the incidence of BSI due to MDR Gram-negative organisms, without any impact on the mortality rate." @default.
• W2982508715 created "2019-11-08" @default.
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• W2982508715 date "2020-06-01" @default.
• W2982508715 modified "2023-10-16" @default.
• W2982508715 title "The effect of an antimicrobial stewardship programme in two intensive care units of a teaching hospital: an interrupted time series analysis" @default.
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• W2982508715 doi "https://doi.org/10.1016/j.cmi.2019.10.021" @default.
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