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- W2982533716 abstract "Connexin39.4 (Cx39.4) and Connexin41.8 (Cx41.8), two gap-junction proteins expressed in both melanophores and xanthophores, are critical for the intercellular communication among pigment cells that is necessary for generating the stripe pigment pattern of zebrafish. We previously characterized the gap-junction properties of Cx39.4 and Cx41.8, but how these proteins contribute to stripe formation remains unclear; this is because distinct types of connexins potentially form heteromeric gap junctions, which precludes accurate elucidation of individual connexin functions in vivo. Here, by arranging Cx39.4 and Cx41.8 expression in pigment cells, we identified the simplest gap-junction network required for stripe generation: Cx39.4 expression in melanophores is required but expression in xanthophores is not necessary for stripe patterning, whereas Cx41.8 expression in xanthophores is sufficient for the patterning, and Cx41.8 expression in melanophores might stabilize the stripes. Moreover, patch-clamp recordings revealed that Cx39.4 gap junctions exhibit spermidine-dependent rectification property. Our results suggest that Cx39.4 facilitates the critical cell-cell interactions between melanophores and xanthophores that mediate a unidirectional activation-signal transfer from xanthophores to melanophores, which is essential for melanophore survival." @default.
- W2982533716 created "2019-11-08" @default.
- W2982533716 creator A5047486745 @default.
- W2982533716 creator A5047963961 @default.
- W2982533716 creator A5070111509 @default.
- W2982533716 creator A5090256437 @default.
- W2982533716 date "2019-01-01" @default.
- W2982533716 modified "2023-09-25" @default.
- W2982533716 title "The minimal gap-junction network among melanophores and xanthophores required for stripe-pattern formation in zebrafish" @default.
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- W2982533716 doi "https://doi.org/10.1242/dev.181065" @default.
- W2982533716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31666235" @default.
- W2982533716 hasPublicationYear "2019" @default.
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