FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982565736> ?p ?o ?g. }

• W2982565736 endingPage "328" @default.
• W2982565736 startingPage "318" @default.
• W2982565736 abstract "Aims To describe the pharmacokinetics (PK) and concentration‐related effects of dobutamine in critically ill neonates in the first days of life, using nonlinear mixed effects modelling. Methods Dosing, plasma concentration and haemodynamic monitoring data from a dose‐escalation study were analysed with a simultaneous population PK and pharmacodynamic model. Neonates receiving continuous infusion of dobutamine 5–20 μg kg −1 min −1 were included. Left ventricular ejection fraction (LVEF) and cardiac output of right and left ventricle (RVO, LVO) were measured on echocardiography; heart rate (HR), mean arterial pressure (MAP), peripheral arterial oxygen saturation and cerebral regional oxygen saturation were recorded from patient monitors. Results Twenty‐eight neonates with median (range) gestational age of 30.4 (22.7–41.0) weeks and birth weight (BW) of 1618 (465–4380) g were included. PK data were adequately described by 1‐compartmental linear structural model. Dobutamine clearance (CL) was described by allometric scaling on BW with sigmoidal maturation function of postmenstrual age (PMA). The final population PK model parameter mean typical value (standard error) estimates, standardised to median BW of 1618 g, were 41.2 (44.5) L h −1 for CL and 5.29 (0.821) L for volume of distribution, which shared a common between subject variability of 29% (17.2%). The relationship between dobutamine concentration and RVO/LVEF was described by linear model, between concentration and LVO/HR/MAP/cerebral fractional tissue oxygen extraction by sigmoidal E max model. Conclusion In the postnatal transitional period, PK of dobutamine was described by a 1‐compartmental linear model, CL related to BW and PMA. A concentration–response relationship with haemodynamic variables has been established." @default.
• W2982565736 created "2019-11-08" @default.
• W2982565736 creator A5009980374 @default.
• W2982565736 creator A5016802288 @default.
• W2982565736 creator A5017071546 @default.
• W2982565736 creator A5023678831 @default.
• W2982565736 creator A5030306270 @default.
• W2982565736 creator A5037294107 @default.
• W2982565736 creator A5044142802 @default.
• W2982565736 creator A5047097508 @default.
• W2982565736 creator A5051754594 @default.
• W2982565736 creator A5059216278 @default.
• W2982565736 creator A5069317379 @default.
• W2982565736 creator A5071078644 @default.
• W2982565736 creator A5090675321 @default.
• W2982565736 creator A5091029981 @default.
• W2982565736 date "2020-01-17" @default.
• W2982565736 modified "2023-09-30" @default.
• W2982565736 title "Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life" @default.
• W2982565736 cites W1579867245 @default.
• W2982565736 cites W1968925070 @default.
• W2982565736 cites W1974213438 @default.
• W2982565736 cites W1975613495 @default.
• W2982565736 cites W1984026103 @default.
• W2982565736 cites W1992039978 @default.
• W2982565736 cites W1992216549 @default.
• W2982565736 cites W1992613377 @default.
• W2982565736 cites W1996872865 @default.
• W2982565736 cites W2009166804 @default.
• W2982565736 cites W2010078703 @default.
• W2982565736 cites W2011457844 @default.
• W2982565736 cites W2028175103 @default.
• W2982565736 cites W2046366059 @default.
• W2982565736 cites W2046457682 @default.
• W2982565736 cites W2057221557 @default.
• W2982565736 cites W2058734479 @default.
• W2982565736 cites W2074109063 @default.
• W2982565736 cites W2122630005 @default.
• W2982565736 cites W2135353667 @default.
• W2982565736 cites W2153873864 @default.
• W2982565736 cites W2504679117 @default.
• W2982565736 cites W2540968481 @default.
• W2982565736 cites W2596498654 @default.
• W2982565736 cites W2605467103 @default.
• W2982565736 cites W2612436750 @default.
• W2982565736 cites W2762063198 @default.
• W2982565736 cites W2845366601 @default.
• W2982565736 cites W2915030804 @default.
• W2982565736 cites W2922372343 @default.
• W2982565736 cites W60008685 @default.
• W2982565736 doi "https://doi.org/10.1111/bcp.14146" @default.
• W2982565736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7015735" @default.
• W2982565736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31657867" @default.
• W2982565736 hasPublicationYear "2020" @default.
• W2982565736 type Work @default.
• W2982565736 sameAs 2982565736 @default.
• W2982565736 citedByCount "5" @default.
• W2982565736 countsByYear W29825657362020 @default.
• W2982565736 countsByYear W29825657362021 @default.
• W2982565736 countsByYear W29825657362022 @default.
• W2982565736 crossrefType "journal-article" @default.
• W2982565736 hasAuthorship W2982565736A5009980374 @default.
• W2982565736 hasAuthorship W2982565736A5016802288 @default.
• W2982565736 hasAuthorship W2982565736A5017071546 @default.
• W2982565736 hasAuthorship W2982565736A5023678831 @default.
• W2982565736 hasAuthorship W2982565736A5030306270 @default.
• W2982565736 hasAuthorship W2982565736A5037294107 @default.
• W2982565736 hasAuthorship W2982565736A5044142802 @default.
• W2982565736 hasAuthorship W2982565736A5047097508 @default.
• W2982565736 hasAuthorship W2982565736A5051754594 @default.
• W2982565736 hasAuthorship W2982565736A5059216278 @default.
• W2982565736 hasAuthorship W2982565736A5069317379 @default.
• W2982565736 hasAuthorship W2982565736A5071078644 @default.
• W2982565736 hasAuthorship W2982565736A5090675321 @default.
• W2982565736 hasAuthorship W2982565736A5091029981 @default.
• W2982565736 hasBestOaLocation W29825657361 @default.
• W2982565736 hasConcept C111113717 @default.
• W2982565736 hasConcept C112705442 @default.
• W2982565736 hasConcept C126322002 @default.
• W2982565736 hasConcept C164705383 @default.
• W2982565736 hasConcept C178853913 @default.
• W2982565736 hasConcept C2777953023 @default.
• W2982565736 hasConcept C2778198053 @default.
• W2982565736 hasConcept C2778376644 @default.
• W2982565736 hasConcept C2778921608 @default.
• W2982565736 hasConcept C2779234561 @default.
• W2982565736 hasConcept C2781185063 @default.
• W2982565736 hasConcept C2908647359 @default.
• W2982565736 hasConcept C42219234 @default.
• W2982565736 hasConcept C54355233 @default.
• W2982565736 hasConcept C71924100 @default.
• W2982565736 hasConcept C78085059 @default.
• W2982565736 hasConcept C80461066 @default.
• W2982565736 hasConcept C84393581 @default.
• W2982565736 hasConcept C86803240 @default.
• W2982565736 hasConcept C99454951 @default.
• W2982565736 hasConceptScore W2982565736C111113717 @default.
• W2982565736 hasConceptScore W2982565736C112705442 @default.

• next