Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982608722> ?p ?o ?g. }
- W2982608722 endingPage "111810" @default.
- W2982608722 startingPage "111810" @default.
- W2982608722 abstract "Poly (ADP-ribose) polymerase-1 (PARP-1) was defined as a new biomarker, which has achieved wide attention in recent years. In this work, we designed a renewable electrochemical sensor based on host-guest recognition for the detection of PARP-1 activity. Mono-(6-Mercapto-6-deoxy)-beta-Cyclodextrin (SH-β-CD) was modified on the electrode surface to recognize the trans-azobenzene labeled dsDNA (Abz-dsDNA). In the presence of PARP-1, PAR with abundant PO43- was generated and reacted with MoO42- to form PMo12O403-, producing strong current. The proposed method avoided the unspecific adsorption effectively and improved the detection accuracy. Under UV irradiation, Abz-dsDNA was removed from the electrode surface because of the configuration change of azobenzene from trans to cis structure, allowing the electrode to be recycled. The sensor realized the linear detection of PARP-1, ranging from 0.01 U to 1.0 U with a detection limit of 0.008 U, which is comparable to results from reported methods. It is expected to be a potential tool for clinical detection because of its high sensitivity and selectivity." @default.
- W2982608722 created "2019-11-08" @default.
- W2982608722 creator A5003799076 @default.
- W2982608722 creator A5018924804 @default.
- W2982608722 creator A5029322489 @default.
- W2982608722 creator A5033080900 @default.
- W2982608722 creator A5047694971 @default.
- W2982608722 creator A5049108933 @default.
- W2982608722 creator A5070463955 @default.
- W2982608722 date "2020-01-01" @default.
- W2982608722 modified "2023-10-17" @default.
- W2982608722 title "Renewable electrochemical sensor for PARP-1 activity detection based on host-guest recognition" @default.
- W2982608722 cites W1954870923 @default.
- W2982608722 cites W1966928113 @default.
- W2982608722 cites W1967396132 @default.
- W2982608722 cites W1970904960 @default.
- W2982608722 cites W1975304357 @default.
- W2982608722 cites W1989302474 @default.
- W2982608722 cites W1990306542 @default.
- W2982608722 cites W1994244567 @default.
- W2982608722 cites W2003345927 @default.
- W2982608722 cites W2033004300 @default.
- W2982608722 cites W2038138097 @default.
- W2982608722 cites W2047230408 @default.
- W2982608722 cites W2052292468 @default.
- W2982608722 cites W2059390029 @default.
- W2982608722 cites W2076106771 @default.
- W2982608722 cites W2151903687 @default.
- W2982608722 cites W2275479137 @default.
- W2982608722 cites W2294597217 @default.
- W2982608722 cites W2346661437 @default.
- W2982608722 cites W2416703957 @default.
- W2982608722 cites W2469521796 @default.
- W2982608722 cites W2511077993 @default.
- W2982608722 cites W2522873012 @default.
- W2982608722 cites W2539944286 @default.
- W2982608722 cites W2573715664 @default.
- W2982608722 cites W2767895484 @default.
- W2982608722 cites W2773984456 @default.
- W2982608722 cites W2774106003 @default.
- W2982608722 cites W2781768309 @default.
- W2982608722 cites W2795450865 @default.
- W2982608722 cites W2799774358 @default.
- W2982608722 cites W2802319424 @default.
- W2982608722 cites W2810268955 @default.
- W2982608722 cites W2908975765 @default.
- W2982608722 cites W2916546708 @default.
- W2982608722 cites W2944138445 @default.
- W2982608722 cites W2946031944 @default.
- W2982608722 cites W2954921251 @default.
- W2982608722 doi "https://doi.org/10.1016/j.bios.2019.111810" @default.
- W2982608722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31710960" @default.
- W2982608722 hasPublicationYear "2020" @default.
- W2982608722 type Work @default.
- W2982608722 sameAs 2982608722 @default.
- W2982608722 citedByCount "12" @default.
- W2982608722 countsByYear W29826087222020 @default.
- W2982608722 countsByYear W29826087222021 @default.
- W2982608722 countsByYear W29826087222022 @default.
- W2982608722 countsByYear W29826087222023 @default.
- W2982608722 crossrefType "journal-article" @default.
- W2982608722 hasAuthorship W2982608722A5003799076 @default.
- W2982608722 hasAuthorship W2982608722A5018924804 @default.
- W2982608722 hasAuthorship W2982608722A5029322489 @default.
- W2982608722 hasAuthorship W2982608722A5033080900 @default.
- W2982608722 hasAuthorship W2982608722A5047694971 @default.
- W2982608722 hasAuthorship W2982608722A5049108933 @default.
- W2982608722 hasAuthorship W2982608722A5070463955 @default.
- W2982608722 hasConcept C118792377 @default.
- W2982608722 hasConcept C119128265 @default.
- W2982608722 hasConcept C147789679 @default.
- W2982608722 hasConcept C150394285 @default.
- W2982608722 hasConcept C161790260 @default.
- W2982608722 hasConcept C17525397 @default.
- W2982608722 hasConcept C178790620 @default.
- W2982608722 hasConcept C185592680 @default.
- W2982608722 hasConcept C188095982 @default.
- W2982608722 hasConcept C192562407 @default.
- W2982608722 hasConcept C2778150588 @default.
- W2982608722 hasConcept C32909587 @default.
- W2982608722 hasConcept C43617362 @default.
- W2982608722 hasConcept C52859227 @default.
- W2982608722 hasConcept C55493867 @default.
- W2982608722 hasConceptScore W2982608722C118792377 @default.
- W2982608722 hasConceptScore W2982608722C119128265 @default.
- W2982608722 hasConceptScore W2982608722C147789679 @default.
- W2982608722 hasConceptScore W2982608722C150394285 @default.
- W2982608722 hasConceptScore W2982608722C161790260 @default.
- W2982608722 hasConceptScore W2982608722C17525397 @default.
- W2982608722 hasConceptScore W2982608722C178790620 @default.
- W2982608722 hasConceptScore W2982608722C185592680 @default.
- W2982608722 hasConceptScore W2982608722C188095982 @default.
- W2982608722 hasConceptScore W2982608722C192562407 @default.
- W2982608722 hasConceptScore W2982608722C2778150588 @default.
- W2982608722 hasConceptScore W2982608722C32909587 @default.
- W2982608722 hasConceptScore W2982608722C43617362 @default.
- W2982608722 hasConceptScore W2982608722C52859227 @default.
- W2982608722 hasConceptScore W2982608722C55493867 @default.