FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982627549> ?p ?o ?g. }

• W2982627549 endingPage "410" @default.
• W2982627549 startingPage "404" @default.
• W2982627549 abstract "This study aims to explore the mechanism of immunosuppression in septic Acute Renal Injury (AKI) and the role of programmed death-1 (PD-1/PD-L1) pathway in septic AKI.This study established a septic AKI model by Cecal ligation and puncture (CLP) in C57/B6 mice, ELISA was used to test the level of lactate and creatinine in serum, blood was collected for flow cytometry and kidney samples for Western blot analyses. This study further analyzed the expression of PD-L1 in kidney and the expression of PD-1 in CD4+, CD8+ T cell, and the number of CD3+ T cells to identify apoptosis in T cells in the blood.The CLP sepsis model induced AKI in C57/B6 mice; The expression of PD-1 and PD-L1 were increased in septic AKI mice; PD-1/PD-L1 induced apoptosis in T cells: the number of lymphocytes decreased by 64%, while the number of CD3+ T cells decreased by 27% compared with the sham group; Results also indicated that lactate up-regulates expression of PD-L1 in the kidney.Lactate activated PD-1/PD-L1 pathway can induce immunosuppression by inducing apoptosis in lymphocytes in septic AKI. Moreover, blocking the receptor of lactate or PD-1/PD-L1 might be a new therapy for septic AKI." @default.
• W2982627549 created "2019-11-08" @default.
• W2982627549 creator A5005283679 @default.
• W2982627549 creator A5026855626 @default.
• W2982627549 creator A5038878630 @default.
• W2982627549 creator A5040545907 @default.
• W2982627549 creator A5045454415 @default.
• W2982627549 creator A5048687013 @default.
• W2982627549 creator A5055283890 @default.
• W2982627549 creator A5058275202 @default.
• W2982627549 creator A5059246379 @default.
• W2982627549 creator A5079631518 @default.
• W2982627549 date "2021-06-01" @default.
• W2982627549 modified "2023-10-15" @default.
• W2982627549 title "Lactate up-regulates the expression of PD-L1 in kidney and causes immunosuppression in septic Acute Renal Injury" @default.
• W2982627549 cites W1976557086 @default.
• W2982627549 cites W1985106225 @default.
• W2982627549 cites W1998427452 @default.
• W2982627549 cites W2004495270 @default.
• W2982627549 cites W2005857592 @default.
• W2982627549 cites W2021237108 @default.
• W2982627549 cites W2026332974 @default.
• W2982627549 cites W2050477250 @default.
• W2982627549 cites W2050919530 @default.
• W2982627549 cites W2056535502 @default.
• W2982627549 cites W2061730726 @default.
• W2982627549 cites W2066671159 @default.
• W2982627549 cites W2084201164 @default.
• W2982627549 cites W2084747579 @default.
• W2982627549 cites W2141559993 @default.
• W2982627549 cites W2144589352 @default.
• W2982627549 cites W2147579197 @default.
• W2982627549 cites W2168234885 @default.
• W2982627549 cites W2181632327 @default.
• W2982627549 cites W2185277106 @default.
• W2982627549 cites W2255110840 @default.
• W2982627549 cites W2282181907 @default.
• W2982627549 cites W2321489821 @default.
• W2982627549 cites W2498270917 @default.
• W2982627549 cites W2526244009 @default.
• W2982627549 cites W2609919582 @default.
• W2982627549 cites W2625416742 @default.
• W2982627549 cites W2752207878 @default.
• W2982627549 cites W2755529729 @default.
• W2982627549 cites W2922700235 @default.
• W2982627549 cites W900373682 @default.
• W2982627549 doi "https://doi.org/10.1016/j.jmii.2019.10.006" @default.
• W2982627549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31727535" @default.
• W2982627549 hasPublicationYear "2021" @default.
• W2982627549 type Work @default.
• W2982627549 sameAs 2982627549 @default.
• W2982627549 citedByCount "15" @default.
• W2982627549 countsByYear W29826275492020 @default.
• W2982627549 countsByYear W29826275492022 @default.
• W2982627549 countsByYear W29826275492023 @default.
• W2982627549 crossrefType "journal-article" @default.
• W2982627549 hasAuthorship W2982627549A5005283679 @default.
• W2982627549 hasAuthorship W2982627549A5026855626 @default.
• W2982627549 hasAuthorship W2982627549A5038878630 @default.
• W2982627549 hasAuthorship W2982627549A5040545907 @default.
• W2982627549 hasAuthorship W2982627549A5045454415 @default.
• W2982627549 hasAuthorship W2982627549A5048687013 @default.
• W2982627549 hasAuthorship W2982627549A5055283890 @default.
• W2982627549 hasAuthorship W2982627549A5058275202 @default.
• W2982627549 hasAuthorship W2982627549A5059246379 @default.
• W2982627549 hasAuthorship W2982627549A5079631518 @default.
• W2982627549 hasBestOaLocation W29826275491 @default.
• W2982627549 hasConcept C114684123 @default.
• W2982627549 hasConcept C126322002 @default.
• W2982627549 hasConcept C167672396 @default.
• W2982627549 hasConcept C190283241 @default.
• W2982627549 hasConcept C203014093 @default.
• W2982627549 hasConcept C2777628635 @default.
• W2982627549 hasConcept C2778384902 @default.
• W2982627549 hasConcept C2780091579 @default.
• W2982627549 hasConcept C2780252810 @default.
• W2982627549 hasConcept C2780306776 @default.
• W2982627549 hasConcept C2780472472 @default.
• W2982627549 hasConcept C553184892 @default.
• W2982627549 hasConcept C55493867 @default.
• W2982627549 hasConcept C71924100 @default.
• W2982627549 hasConcept C86803240 @default.
• W2982627549 hasConcept C8891405 @default.
• W2982627549 hasConceptScore W2982627549C114684123 @default.
• W2982627549 hasConceptScore W2982627549C126322002 @default.
• W2982627549 hasConceptScore W2982627549C167672396 @default.
• W2982627549 hasConceptScore W2982627549C190283241 @default.
• W2982627549 hasConceptScore W2982627549C203014093 @default.
• W2982627549 hasConceptScore W2982627549C2777628635 @default.
• W2982627549 hasConceptScore W2982627549C2778384902 @default.
• W2982627549 hasConceptScore W2982627549C2780091579 @default.
• W2982627549 hasConceptScore W2982627549C2780252810 @default.
• W2982627549 hasConceptScore W2982627549C2780306776 @default.
• W2982627549 hasConceptScore W2982627549C2780472472 @default.
• W2982627549 hasConceptScore W2982627549C553184892 @default.
• W2982627549 hasConceptScore W2982627549C55493867 @default.
• W2982627549 hasConceptScore W2982627549C71924100 @default.
• W2982627549 hasConceptScore W2982627549C86803240 @default.

• next