FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982634885> ?p ?o ?g. }

• W2982634885 abstract "Abstract Disruption of cortical connectivity likely contributes to loss of consciousness (LOC) during both sleep and general anesthesia, but the degree of overlap in the underlying mechanisms is unclear. Both sleep and anesthesia comprise states of varying levels of arousal and consciousness, including states of largely maintained consciousness (sleep: N1, REM; anesthesia: sedated but responsive) as well as states of substantially reduced consciousness (sleep: N2/N3; anesthesia: unresponsive). Here, we tested the hypotheses that (1) cortical connectivity will reflect clear changes when transitioning into states of reduced consciousness, and (2) these changes are similar for arousal states of comparable levels of consciousness during sleep and anesthesia. Using intracranial recordings from five neurosurgical patients, we compared resting state cortical functional connectivity (as measured by weighted phase lag index) in the same subjects across arousal states during natural sleep [wake (WS), N1, N2, N3, REM] and propofol anesthesia [pre-drug wake (WA), sedated/responsive (S) and unresponsive (U)]. In wake states WS and WA, alpha-band connectivity within and between temporal, parietal and occipital regions was dominant. This pattern was largely unchanged in N1, REM and S. Transitions into states of reduced consciousness N2, N3 and U were characterized by dramatic and strikingly similar changes in connectivity, with dominant connections shifting to frontal cortex. We suggest that shifts from temporo-parieto-occipital to frontal cortical connectivity may reflect impaired sensory processing in states of reduced consciousness. The data indicate that functional connectivity can serve as a biomarker of arousal state and suggest common mechanisms of LOC in sleep and anesthesia." @default.
• W2982634885 created "2019-11-08" @default.
• W2982634885 creator A5006555763 @default.
• W2982634885 creator A5014696805 @default.
• W2982634885 creator A5028976280 @default.
• W2982634885 creator A5036623581 @default.
• W2982634885 creator A5037469144 @default.
• W2982634885 creator A5039476381 @default.
• W2982634885 creator A5065382123 @default.
• W2982634885 creator A5071133985 @default.
• W2982634885 date "2019-10-30" @default.
• W2982634885 modified "2023-10-14" @default.
• W2982634885 title "Cortical functional connectivity indexes arousal state during sleep and anesthesia" @default.
• W2982634885 cites W1500965466 @default.
• W2982634885 cites W1606491053 @default.
• W2982634885 cites W1902335101 @default.
• W2982634885 cites W1966641148 @default.
• W2982634885 cites W1966649586 @default.
• W2982634885 cites W1966689044 @default.
• W2982634885 cites W1976352460 @default.
• W2982634885 cites W1977518154 @default.
• W2982634885 cites W1978813754 @default.
• W2982634885 cites W1979155542 @default.
• W2982634885 cites W1983192672 @default.
• W2982634885 cites W1986373976 @default.
• W2982634885 cites W1988148915 @default.
• W2982634885 cites W2000552763 @default.
• W2982634885 cites W2002996884 @default.
• W2982634885 cites W2003454395 @default.
• W2982634885 cites W2004454719 @default.
• W2982634885 cites W2005523405 @default.
• W2982634885 cites W2007581301 @default.
• W2982634885 cites W2009606325 @default.
• W2982634885 cites W2015303758 @default.
• W2982634885 cites W2016127971 @default.
• W2982634885 cites W2022438346 @default.
• W2982634885 cites W2027444377 @default.
• W2982634885 cites W2031728051 @default.
• W2982634885 cites W2041570400 @default.
• W2982634885 cites W2042921481 @default.
• W2982634885 cites W2045880882 @default.
• W2982634885 cites W2049289092 @default.
• W2982634885 cites W2052644075 @default.
• W2982634885 cites W2065292719 @default.
• W2982634885 cites W2066637614 @default.
• W2982634885 cites W2078246625 @default.
• W2982634885 cites W2094508169 @default.
• W2982634885 cites W2096525313 @default.
• W2982634885 cites W2111177605 @default.
• W2982634885 cites W2120228672 @default.
• W2982634885 cites W2121409298 @default.
• W2982634885 cites W2125113735 @default.
• W2982634885 cites W2127958135 @default.
• W2982634885 cites W2135390742 @default.
• W2982634885 cites W2137456793 @default.
• W2982634885 cites W2138635047 @default.
• W2982634885 cites W2140750662 @default.
• W2982634885 cites W2149745827 @default.
• W2982634885 cites W2150343680 @default.
• W2982634885 cites W2150641541 @default.
• W2982634885 cites W2161794281 @default.
• W2982634885 cites W2164865141 @default.
• W2982634885 cites W2165892338 @default.
• W2982634885 cites W2167021426 @default.
• W2982634885 cites W2220576269 @default.
• W2982634885 cites W2232938174 @default.
• W2982634885 cites W2345483071 @default.
• W2982634885 cites W2394834952 @default.
• W2982634885 cites W2410654512 @default.
• W2982634885 cites W2420668911 @default.
• W2982634885 cites W2511409893 @default.
• W2982634885 cites W2516724460 @default.
• W2982634885 cites W2528135897 @default.
• W2982634885 cites W2607054356 @default.
• W2982634885 cites W2618285320 @default.
• W2982634885 cites W2702268872 @default.
• W2982634885 cites W2737674920 @default.
• W2982634885 cites W2737838117 @default.
• W2982634885 cites W2744610723 @default.
• W2982634885 cites W2754834749 @default.
• W2982634885 cites W2765271628 @default.
• W2982634885 cites W2765392035 @default.
• W2982634885 cites W2765649845 @default.
• W2982634885 cites W2768202056 @default.
• W2982634885 cites W2788317459 @default.
• W2982634885 cites W2888088680 @default.
• W2982634885 cites W2895353928 @default.
• W2982634885 cites W2903063728 @default.
• W2982634885 cites W2912563005 @default.
• W2982634885 cites W2951224431 @default.
• W2982634885 cites W2952447148 @default.
• W2982634885 cites W2974974162 @default.
• W2982634885 doi "https://doi.org/10.1101/823963" @default.
• W2982634885 hasPublicationYear "2019" @default.
• W2982634885 type Work @default.
• W2982634885 sameAs 2982634885 @default.
• W2982634885 citedByCount "0" @default.
• W2982634885 crossrefType "posted-content" @default.
• W2982634885 hasAuthorship W2982634885A5006555763 @default.
• W2982634885 hasAuthorship W2982634885A5014696805 @default.

• next