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- W2982638863 abstract "We have derivatized Momordica saponins (MS) I and II through their coupling at C3 glucuronic acid site with dodecylamine. The derivatives show significantly different immunostimulant activity profiles from their respective natural parent saponins. In particular, adjuvant VSA-1 (5), the derivative of MS I, potentiates a significantly higher IgG2a responose than the corresponding natural product. Its IgG1 and IgG2a production is similar to that of GPI-0100, indicating a potential mixed and antigen-specific Th1/Th2 immune response, which is different from the Th2 immunity induced by the natural saponin MS I. In addition, toxicity evaluations show that adjuvant VSA-1 (5) is much less toxic than the widely used natural saponin mixture Quil A. These results prove that derivatizing Momordica saponins can be a viable way for easy access to structurally defined saponin immunostimulants with favorable adjvuant activity and low toxicity." @default.
- W2982638863 created "2019-11-08" @default.
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- W2982638863 date "2019-10-28" @default.
- W2982638863 modified "2023-10-12" @default.
- W2982638863 title "Vaccine Adjuvants Derivatized from <i>Momordica</i> Saponins I and II" @default.
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- W2982638863 doi "https://doi.org/10.1021/acs.jmedchem.9b01511" @default.
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