FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982685462> ?p ?o ?g. }

• W2982685462 endingPage "e031339" @default.
• W2982685462 startingPage "e031339" @default.
• W2982685462 abstract "Introduction Several studies suggest that gut microbiota may play an important role in allergic diseases. The present trial aims to examine effects of the probiotic Enterococcus faecalis on symptoms of allergic rhinitis in patients. Effects of this probiotic on the immune system have been reported by several studies, but the majority of the previous trials were animal studies. In addition, it is well known that symptoms in allergic rhinitis are prone to exhibit high placebo responses. Moreover, recent studies report that even placebos without deception (open-label placebos) are highly effective in reducing symptoms of allergic rhinitis. Our study design combines both new approaches to assess effects on allergic symptoms in patients. The objective of this study is to compare the effects of a probiotic treatment ( E. faecalis ) with effects seen by open-label placebo, concealed placebo treatment and no treatment control. Methods and analysis A total of 120 patients with allergic rhinitis will be randomly assigned to one of four different groups: a double-blind probiotic/placebo group (groups 1 and 2), an open-label placebo group (group 3) and a no-treatment group (group 4) to control for spontaneous variation of symptoms. The primary outcome is the evaluation of allergic symptoms using the Combined Symptoms Medication Score. Furthermore, health-related quality of life is examined (Rhinitis Quality of Life Questionnaire). Secondary outcomes include a visual analogue scale on allergic burden and a second quality of life questionnaire. This report describes the study design of the randomised controlled trial. Ethics and dissemination The study design was approved by the ethical committee of the UKT Department of Psychosomatic Medicine and Psychotherapy, Tübingen, Germany. The trial is registered at the German Clinical Trials Register ( www.drks.de , DRKS00015804). The trial results will be published in peer-reviewed journals and at conferences. Trial registration number German Clinical Trials Register ( www.drks.de , DRKS00015804); Pre-results." @default.
• W2982685462 created "2019-11-08" @default.
• W2982685462 creator A5073465749 @default.
• W2982685462 creator A5082878585 @default.
• W2982685462 date "2019-10-01" @default.
• W2982685462 modified "2023-10-16" @default.
• W2982685462 title "Effects of a probiotic treatment (<i>Enterococcus faecalis</i>) and open-label placebo on symptoms of allergic rhinitis: study protocol for a randomised controlled trial" @default.
• W2982685462 cites W1008047686 @default.
• W2982685462 cites W137741839 @default.
• W2982685462 cites W1527957830 @default.
• W2982685462 cites W1837440608 @default.
• W2982685462 cites W1885556436 @default.
• W2982685462 cites W188765527 @default.
• W2982685462 cites W1949939646 @default.
• W2982685462 cites W1980453188 @default.
• W2982685462 cites W1988066089 @default.
• W2982685462 cites W2000103109 @default.
• W2982685462 cites W2000739801 @default.
• W2982685462 cites W2004785338 @default.
• W2982685462 cites W2010953182 @default.
• W2982685462 cites W2018533701 @default.
• W2982685462 cites W2025068369 @default.
• W2982685462 cites W2035831689 @default.
• W2982685462 cites W2037377025 @default.
• W2982685462 cites W2057187219 @default.
• W2982685462 cites W2059012840 @default.
• W2982685462 cites W2061914765 @default.
• W2982685462 cites W2061990838 @default.
• W2982685462 cites W2065221709 @default.
• W2982685462 cites W2074474404 @default.
• W2982685462 cites W2084205044 @default.
• W2982685462 cites W2085650940 @default.
• W2982685462 cites W2089653610 @default.
• W2982685462 cites W2105330971 @default.
• W2982685462 cites W2117964850 @default.
• W2982685462 cites W2120948675 @default.
• W2982685462 cites W2123463790 @default.
• W2982685462 cites W2124712583 @default.
• W2982685462 cites W2129236268 @default.
• W2982685462 cites W2137348931 @default.
• W2982685462 cites W2145536121 @default.
• W2982685462 cites W2155701010 @default.
• W2982685462 cites W2158029086 @default.
• W2982685462 cites W2158897084 @default.
• W2982685462 cites W2165174834 @default.
• W2982685462 cites W2169836118 @default.
• W2982685462 cites W2171678294 @default.
• W2982685462 cites W2240097435 @default.
• W2982685462 cites W2274239973 @default.
• W2982685462 cites W2395321961 @default.
• W2982685462 cites W2405691741 @default.
• W2982685462 cites W2406291021 @default.
• W2982685462 cites W2416544760 @default.
• W2982685462 cites W2464938515 @default.
• W2982685462 cites W2465530071 @default.
• W2982685462 cites W2494623578 @default.
• W2982685462 cites W2505539031 @default.
• W2982685462 cites W2530932886 @default.
• W2982685462 cites W2531892847 @default.
• W2982685462 cites W2541915598 @default.
• W2982685462 cites W2585987478 @default.
• W2982685462 cites W2589992901 @default.
• W2982685462 cites W2592714863 @default.
• W2982685462 cites W2608166496 @default.
• W2982685462 cites W2768876373 @default.
• W2982685462 cites W2791426003 @default.
• W2982685462 cites W2791565596 @default.
• W2982685462 cites W2799380720 @default.
• W2982685462 cites W2801664545 @default.
• W2982685462 cites W2888169281 @default.
• W2982685462 cites W2888509800 @default.
• W2982685462 cites W2895598668 @default.
• W2982685462 cites W2895621824 @default.
• W2982685462 cites W2915764263 @default.
• W2982685462 cites W4240922783 @default.
• W2982685462 cites W4292806894 @default.
• W2982685462 cites W908674981 @default.
• W2982685462 doi "https://doi.org/10.1136/bmjopen-2019-031339" @default.
• W2982685462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6830672" @default.
• W2982685462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31662387" @default.
• W2982685462 hasPublicationYear "2019" @default.
• W2982685462 type Work @default.
• W2982685462 sameAs 2982685462 @default.
• W2982685462 citedByCount "12" @default.
• W2982685462 countsByYear W29826854622020 @default.
• W2982685462 countsByYear W29826854622021 @default.
• W2982685462 countsByYear W29826854622022 @default.
• W2982685462 countsByYear W29826854622023 @default.
• W2982685462 crossrefType "journal-article" @default.
• W2982685462 hasAuthorship W2982685462A5073465749 @default.
• W2982685462 hasAuthorship W2982685462A5082878585 @default.
• W2982685462 hasBestOaLocation W29826854621 @default.
• W2982685462 hasConcept C126322002 @default.
• W2982685462 hasConcept C14184104 @default.
• W2982685462 hasConcept C142724271 @default.
• W2982685462 hasConcept C159110408 @default.
• W2982685462 hasConcept C168563851 @default.
• W2982685462 hasConcept C1862650 @default.

• next