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- W2982705191 abstract "Watermelon is a good source of citrulline, a non-protein amino acid. Citrulline has several therapeutic and clinical implications as it produces nitric oxide via arginine. In plants, citrulline plays a pivotal role in nitrogen transport and osmoprotection. The purpose of this study was to identify single nucleotide polymorphism (SNP) markers associated with citrulline metabolism using a genome-wide association study (GWAS) and understand the role of citrulline in watermelon domestication. A watermelon collection consisting of 187 wild, landraces, and cultivated accessions was used to estimate citrulline content. An association analysis involved a total of 12,125 SNPs with a minor allele frequency (MAF) >0.05 in understanding the population structure and phylogeny in light of citrulline accumulation. Wild egusi types and landraces contained low to medium citrulline content, whereas cultivars had higher content, which suggests that obtaining higher content of citrulline is a domesticated trait. GWAS analysis identified candidate genes (ferrochelatase and acetolactatesynthase) showing a significant association of SNPs with citrulline content. Haplotype networking indicated positive selection from wild to domesticated watermelon. To our knowledge, this is the first study showing genetic regulation of citrulline variation in plants by using a GWAS strategy. These results provide new insights into the citrulline metabolism in plants and the possibility of incorporating high citrulline as a trait in watermelon breeding programs." @default.
- W2982705191 created "2019-11-08" @default.
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- W2982705191 date "2019-10-29" @default.
- W2982705191 modified "2023-10-15" @default.
- W2982705191 title "Haplotype Networking of GWAS Hits for Citrulline Variation Associated with the Domestication of Watermelon" @default.
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- W2982705191 doi "https://doi.org/10.3390/ijms20215392" @default.
- W2982705191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6862219" @default.
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- W2982705191 hasPublicationYear "2019" @default.
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