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• W2982730113 abstract "Manganese homeostasis is primarily regulated at the level of transport. Bacillus subtilis MntR serves as a Mn(II)-activated repressor of importer genes ( mntH and mntABC ) and an activator of efflux genes ( mneP and mneS ). Elevated intracellular Mn(II) also binds to Mn-sensing riboswitches to activate transcription of yybP and ykoY , which encodes a TerC family member. Here, we demonstrate that two TerC family proteins, YceF and YkoY, help prevent Mn(II) intoxication. TerC family proteins are widespread in bacteria and may influence host-pathogen interactions, but their effects on Mn(II) homeostasis are unclear. Our results suggest that TerC proteins work by Mn(II) export under Mn(II) overload conditions to help alleviate toxicity." @default.
• W2982730113 created "2019-11-22" @default.
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• W2982730113 date "2020-01-02" @default.
• W2982730113 modified "2023-10-10" @default.
• W2982730113 title "<i>Bacillus subtilis</i>TerC Family Proteins Help Prevent Manganese Intoxication" @default.
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• W2982730113 doi "https://doi.org/10.1128/jb.00624-19" @default.
• W2982730113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6941523" @default.
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