Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982763722> ?p ?o ?g. }
- W2982763722 endingPage "30" @default.
- W2982763722 startingPage "17" @default.
- W2982763722 abstract "Neuropathic pain is a complication after a spinal nerve injury. The inflammasomes are now identified to be responsible for triggering inflammation in neuropathic pain. Autophagy participates in the process of neuropathic pain and can regulate the inflammasome activation in different diseases. Our previous research reported that hydrogen exerted a protective effect against neuropathic pain. Therefore, we focused on the mechanism and role of autophagy and inflammasome, by which hydrogen alleviated the hyperpathia induced by neuropathic pain. The results showed that neuropathic pain stimulated activation of inflammasome NLRP3 and autophagy pathway in the microglial cells of the spinal cord. The inhibition of NLRP3 inhibited the hyperpathia induced by spinal nerve litigation surgery. The absence of autophagy aggravated the inflammasome activity and hyperpathia. Hydrogen promoted autophagy related protein expression, inhibited the inflammasome NLRP3 pathway activation, and relieved the hyperpathia induced by neuropathic pain. Hydrogen treatment could alleviate hyperpathia by autophagy-mediated NLRP3 inactivation." @default.
- W2982763722 created "2019-11-22" @default.
- W2982763722 creator A5029647632 @default.
- W2982763722 creator A5034382078 @default.
- W2982763722 creator A5042316902 @default.
- W2982763722 creator A5063271864 @default.
- W2982763722 creator A5085490591 @default.
- W2982763722 creator A5091049716 @default.
- W2982763722 date "2019-11-01" @default.
- W2982763722 modified "2023-10-14" @default.
- W2982763722 title "Hydrogen-rich Saline Alleviated the Hyperpathia and Microglia Activation via Autophagy Mediated Inflammasome Inactivation in Neuropathic Pain Rats" @default.
- W2982763722 cites W1534148228 @default.
- W2982763722 cites W1591803971 @default.
- W2982763722 cites W1599948477 @default.
- W2982763722 cites W1820088939 @default.
- W2982763722 cites W1965866432 @default.
- W2982763722 cites W1971880256 @default.
- W2982763722 cites W1980934317 @default.
- W2982763722 cites W1989833758 @default.
- W2982763722 cites W1990420318 @default.
- W2982763722 cites W1993064649 @default.
- W2982763722 cites W1996965292 @default.
- W2982763722 cites W1997801295 @default.
- W2982763722 cites W2016052090 @default.
- W2982763722 cites W2016560481 @default.
- W2982763722 cites W2030008286 @default.
- W2982763722 cites W2039356011 @default.
- W2982763722 cites W2049925066 @default.
- W2982763722 cites W2065033307 @default.
- W2982763722 cites W2075058886 @default.
- W2982763722 cites W2080199676 @default.
- W2982763722 cites W2108757438 @default.
- W2982763722 cites W2116562304 @default.
- W2982763722 cites W2125726879 @default.
- W2982763722 cites W2127894556 @default.
- W2982763722 cites W2132321191 @default.
- W2982763722 cites W2139559251 @default.
- W2982763722 cites W2148274009 @default.
- W2982763722 cites W2157976653 @default.
- W2982763722 cites W2290088765 @default.
- W2982763722 cites W2409306902 @default.
- W2982763722 cites W2436723632 @default.
- W2982763722 cites W2465564629 @default.
- W2982763722 cites W2471132300 @default.
- W2982763722 cites W2535664532 @default.
- W2982763722 cites W2550360608 @default.
- W2982763722 cites W2561437065 @default.
- W2982763722 cites W2581392984 @default.
- W2982763722 cites W2616329870 @default.
- W2982763722 cites W2737697856 @default.
- W2982763722 cites W2745493179 @default.
- W2982763722 cites W2748669322 @default.
- W2982763722 cites W2752475552 @default.
- W2982763722 cites W2758132316 @default.
- W2982763722 cites W2760692225 @default.
- W2982763722 cites W2765933829 @default.
- W2982763722 cites W2766474851 @default.
- W2982763722 cites W2786315758 @default.
- W2982763722 cites W2786438865 @default.
- W2982763722 cites W2788508150 @default.
- W2982763722 cites W2796768258 @default.
- W2982763722 cites W2800531295 @default.
- W2982763722 cites W2802787430 @default.
- W2982763722 cites W2804970493 @default.
- W2982763722 cites W2807221969 @default.
- W2982763722 cites W396067388 @default.
- W2982763722 cites W582182564 @default.
- W2982763722 doi "https://doi.org/10.1016/j.neuroscience.2019.10.046" @default.
- W2982763722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31689487" @default.
- W2982763722 hasPublicationYear "2019" @default.
- W2982763722 type Work @default.
- W2982763722 sameAs 2982763722 @default.
- W2982763722 citedByCount "43" @default.
- W2982763722 countsByYear W29827637222020 @default.
- W2982763722 countsByYear W29827637222021 @default.
- W2982763722 countsByYear W29827637222022 @default.
- W2982763722 countsByYear W29827637222023 @default.
- W2982763722 crossrefType "journal-article" @default.
- W2982763722 hasAuthorship W2982763722A5029647632 @default.
- W2982763722 hasAuthorship W2982763722A5034382078 @default.
- W2982763722 hasAuthorship W2982763722A5042316902 @default.
- W2982763722 hasAuthorship W2982763722A5063271864 @default.
- W2982763722 hasAuthorship W2982763722A5085490591 @default.
- W2982763722 hasAuthorship W2982763722A5091049716 @default.
- W2982763722 hasConcept C118552586 @default.
- W2982763722 hasConcept C169760540 @default.
- W2982763722 hasConcept C185592680 @default.
- W2982763722 hasConcept C190283241 @default.
- W2982763722 hasConcept C203014093 @default.
- W2982763722 hasConcept C203522944 @default.
- W2982763722 hasConcept C2776914184 @default.
- W2982763722 hasConcept C2777107010 @default.
- W2982763722 hasConcept C2777209026 @default.
- W2982763722 hasConcept C2779830541 @default.
- W2982763722 hasConcept C2780775167 @default.
- W2982763722 hasConcept C42219234 @default.
- W2982763722 hasConcept C55493867 @default.
- W2982763722 hasConcept C71924100 @default.