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• W2982853535 abstract "Current standard treatment for patients with locally advanced cervical squamous cell carcinoma (LACSCC) is concurrent chemoradiotherapy (CCRT). For the majority of Chinese patients with LACSCC, after properly executed CCRT, local control of the disease is achieved, and consecutively distant relapse becomes the main cause of death for these patients. Adjuvant chemotherapy (ACT) can be given in an attempt to improve survival. This multicenter retrospective study aimed to evaluate the effect of ACT after CCRT on survival of Chinese patients with LACSCC compared with CCRT alone. A total of 505 patients (median age 53 years, range 35-71 years) with LACSCC who received treatment (CCRT alone or ACT after CCRT) between 2007 and 2017 were enrolled at 6 multicenter study sites. CCRT (452 patients) was performed with intravenous cisplatin weekly during external beam radiation therapy. ACT was administered to 53 patients and comprised platinum-based regimen administered monthly after CCRT, and repeated every 4 weeks for 1 to 4 cycles. Kaplan-Meier estimates at 5-years were calculated for overall survival (OS), disease-free survival (DFS), progression-free survival (PFS) and distance metastasis-free survival (DMFS). Multivariate COX regression analysis was carried out to screen the factors influencing the survival. The Probit model was used to establish a prediction model between factors and survival. The results showed that the OS rates among the patients were 86.5% in the CCRT alone group and 90.5% in the ACT after CCRT group (P = 0.349). The DFS rates were 81.4% and 85.2% (P = 0.360). The PFS rates were 80.8% and 86.8% (P = 0.188). The DMFS rates were 88.7% and 98.1% (P = 0.029). The number of cycles of ACT (1 cycle vs. ≥ 2 cycles) did not affect the prognosis of patients with LACSCC. The tumor marker carbohydrate antigen 125 (CA125) was found to be related with survival time. CA125 > 35 U/mL may be one of the indicators for ACT to improve survival. This study showed that ACT after CCRT is beneficial for DMFS in Chinese patients with LACSCC. In practice, the number of ACT cycles should be carefully considered as appropriate. CA125 may be a relevant factor influencing prognosis, and its value is inversely proportional to survival time. In LACSCC patients with CA125 > 35 U/mL, ACT after CCRT may be more important in improving prognosis compared with CCRT alone." @default.
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• W2982853535 date "2019-09-01" @default.
• W2982853535 modified "2023-09-27" @default.
• W2982853535 title "The Preliminary Results of a Retrospective Multicenter Study on Clinical Effect for Chinese Patients with Locally Advanced Cervical Squamous Cell Carcinoma Undergoing Adjuvant Chemotherapy after Concurrent Chemoradiotherapy" @default.
• W2982853535 doi "https://doi.org/10.1016/j.ijrobp.2019.06.1748" @default.
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