FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982910767> ?p ?o ?g. }

• W2982910767 endingPage "9493" @default.
• W2982910767 startingPage "9481" @default.
• W2982910767 abstract "Inflammation is implicated in both hepatic cirrhosis development and hepatocellular carcinogenesis, and treatment with long-acting glucocorticoid dexamethasone prevented liver carcinogenesis in mice. However, it is unclear whether glucocorticoids have anti-inflammatory effect on hepatocellular carcinoma (HCC) and if short-acting glucocorticoids (with fewer adverse effects) inhibit paraneoplastic inflammation and HCC progression.To investigate whether different types of anti-inflammatory agents attenuate HCC progression, the current study compared effects of treatments with hydrocortisone (a short-acting glucocorticoid) or aspirin on HCC progression. HCC was induced in diethylnitrosamine-treated rats which were randomly divided into 4 groups (n=8), respectively receiving orally once daily vehicle, glucuronolactone, glucuronolactone+hydrocortisone, and glucuronolactone+aspirin. Diethylnitrosamine (DEN) was given to rats in drinking water (100mg/L) to induce HCC. At weeks 12 and 16 post-induction, effects were compared on HCC nodule formation, microvessel density, and macrophage infiltration, and levels of paraneoplastic protein expression of tumor necrosis factor (TNF)-α, p38 mitogen-activated protein kinase (p38), phosphorylated p38 (p-p38), nuclear factor (NF)-κB, interleukin (IL)-10, hepatocyte growth factor (HGF), transforming growth factor (TGF)-β1 and vascular endothelial growth factor (VEGF).Compared to the model and glucuronolactone alone groups, HCC nodule number and microvessel density in the glucuronolactone+hydrocortisone group were significantly lower at week 12. At week 12 but not week 16, significantly lower levels of macrophages, TNF-α, p-p38, NF-κB, IL-10, HGF, TGF-β1 and VEGF were observed in the paraneoplastic tissue of the glucuronolactone+hydrocortisone group when compared with the control and glucuronolactone groups.The results suggest that hydrocortisone treatment reduces macrophage polarization, expression of inflammatory and anti-inflammatory cytokines, and angiogenesis in paraneoplastic tissue, and attenuates early HCC progression. Although hydrocortisone did not have attenuation effect on advanced solid tumor, the current study shows the potential benefits and supports potential clinical use of hydrocortisone in attenuating early progression of HCC, which is through suppressing paraneoplastic inflammation and angiogenesis." @default.
• W2982910767 created "2019-11-22" @default.
• W2982910767 creator A5002797400 @default.
• W2982910767 creator A5011669263 @default.
• W2982910767 creator A5024940456 @default.
• W2982910767 creator A5045478032 @default.
• W2982910767 creator A5047737377 @default.
• W2982910767 creator A5051229707 @default.
• W2982910767 creator A5052787170 @default.
• W2982910767 creator A5062989544 @default.
• W2982910767 creator A5065140987 @default.
• W2982910767 creator A5086487768 @default.
• W2982910767 date "2019-11-01" @default.
• W2982910767 modified "2023-10-14" @default.
• W2982910767 title "<p>Hydrocortisone Suppresses Early Paraneoplastic Inflammation And Angiogenesis To Attenuate Early Hepatocellular Carcinoma Progression In Rats</p>" @default.
• W2982910767 cites W1037516097 @default.
• W2982910767 cites W142715042 @default.
• W2982910767 cites W1522760404 @default.
• W2982910767 cites W1604619549 @default.
• W2982910767 cites W1835730169 @default.
• W2982910767 cites W1963976924 @default.
• W2982910767 cites W1981368166 @default.
• W2982910767 cites W1987553222 @default.
• W2982910767 cites W1989157491 @default.
• W2982910767 cites W1994553847 @default.
• W2982910767 cites W1998976242 @default.
• W2982910767 cites W2010568740 @default.
• W2982910767 cites W2016828736 @default.
• W2982910767 cites W2057796145 @default.
• W2982910767 cites W2062030781 @default.
• W2982910767 cites W2069668308 @default.
• W2982910767 cites W2078677977 @default.
• W2982910767 cites W2086345909 @default.
• W2982910767 cites W2089224387 @default.
• W2982910767 cites W2091223566 @default.
• W2982910767 cites W2106026513 @default.
• W2982910767 cites W2128227067 @default.
• W2982910767 cites W2155410757 @default.
• W2982910767 cites W2176970926 @default.
• W2982910767 cites W2188544031 @default.
• W2982910767 cites W2232713286 @default.
• W2982910767 cites W2250984169 @default.
• W2982910767 cites W2269805670 @default.
• W2982910767 cites W2413352208 @default.
• W2982910767 cites W2501320070 @default.
• W2982910767 cites W2509769102 @default.
• W2982910767 cites W2514802108 @default.
• W2982910767 cites W2526447978 @default.
• W2982910767 cites W2527632973 @default.
• W2982910767 cites W2531156389 @default.
• W2982910767 cites W2537018529 @default.
• W2982910767 cites W2560661124 @default.
• W2982910767 cites W2565367159 @default.
• W2982910767 cites W2572206076 @default.
• W2982910767 cites W2587179537 @default.
• W2982910767 cites W2592375565 @default.
• W2982910767 cites W2594491387 @default.
• W2982910767 cites W2606086307 @default.
• W2982910767 cites W2606474691 @default.
• W2982910767 cites W2610204288 @default.
• W2982910767 cites W2613572544 @default.
• W2982910767 cites W2625119531 @default.
• W2982910767 cites W2625902475 @default.
• W2982910767 cites W2661190352 @default.
• W2982910767 cites W2732241053 @default.
• W2982910767 cites W2734590576 @default.
• W2982910767 cites W2735800947 @default.
• W2982910767 cites W2735845387 @default.
• W2982910767 cites W2736049398 @default.
• W2982910767 cites W2738709136 @default.
• W2982910767 cites W2738917939 @default.
• W2982910767 cites W2744749871 @default.
• W2982910767 cites W2752155250 @default.
• W2982910767 cites W2755503471 @default.
• W2982910767 cites W2790510140 @default.
• W2982910767 cites W2898750672 @default.
• W2982910767 cites W2917837889 @default.
• W2982910767 cites W294815049 @default.
• W2982910767 cites W2966549619 @default.
• W2982910767 cites W3023662224 @default.
• W2982910767 cites W37497634 @default.
• W2982910767 cites W58983264 @default.
• W2982910767 cites W31208052 @default.
• W2982910767 doi "https://doi.org/10.2147/ott.s224618" @default.
• W2982910767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6850701" @default.
• W2982910767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31807025" @default.
• W2982910767 hasPublicationYear "2019" @default.
• W2982910767 type Work @default.
• W2982910767 sameAs 2982910767 @default.
• W2982910767 citedByCount "5" @default.
• W2982910767 countsByYear W29829107672020 @default.
• W2982910767 countsByYear W29829107672021 @default.
• W2982910767 countsByYear W29829107672022 @default.
• W2982910767 countsByYear W29829107672023 @default.
• W2982910767 crossrefType "journal-article" @default.
• W2982910767 hasAuthorship W2982910767A5002797400 @default.
• W2982910767 hasAuthorship W2982910767A5011669263 @default.
• W2982910767 hasAuthorship W2982910767A5024940456 @default.

• next