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- W2982932353 abstract "Abstract Relapsing polychondritis (RP) is a rare immune-mediated disease affecting cartilaginous structures. Respiratory tract manifestations are frequent and constitute a major cause of morbidity and mortality. The present review of the literature was designed to assess the efficacy of tumor necrosis factor alpha (TNF-α) inhibitors in respiratory tract involvement of RP. A MEDLINE literature search was performed from January 2000 to December 2016 to identify all studies and case reports of anti-TNF-α therapy in RP. Articles published in English or French concerning patients with respiratory tract involvement were eligible. Two authors (JB, FL) independently reviewed and extracted data concerning each patient and 2 personal cases were added. Treatment efficacy was assessed according to systemic and/or respiratory criteria. A total of 28 patients (mean age: 41.6 years; 16 females/12 males) were included in the final analysis. Anti-TNF-α therapy was associated with improved health status and respiratory symptoms in 67.8% and 60.1% of cases, respectively. These results suggest that TNF-α inhibitors could be considered for the treatment of respiratory tract involvement of RP." @default.
- W2982932353 created "2019-11-22" @default.
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- W2982932353 date "2019-11-01" @default.
- W2982932353 modified "2023-10-17" @default.
- W2982932353 title "Assessment of TNF-α inhibitors in airway involvement of relapsing polychondritis" @default.
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- W2982932353 doi "https://doi.org/10.1097/md.0000000000017768" @default.
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