Matches in SemOpenAlex for { <https://semopenalex.org/work/W2982978420> ?p ?o ?g. }
- W2982978420 endingPage "110954" @default.
- W2982978420 startingPage "110954" @default.
- W2982978420 abstract "Due to the growing number of applications of cadmium oxide nanoparticles (CdO NPs), there is a concern about their potential deleterious effects. The objective of our study was to investigate the effect of CdO NPs on the immune response, renal and intestine oxidative stress, blood antioxidant defence, renal fibrotic response, bone density and mineral content. Six-week-old female ICR mice were exposed to CdO NPs for 6 weeks by inhalation (particle size: 9.82 nm, mass concentration: 31.7 μg CdO/m3, total deposited dose: 0.195 μg CdO/g body weight). CdO NPs increased percentage of thymus CD3e+CD8a+ cells and moderately enhanced splenocyte proliferation and production of cytokines and chemokines. CdO NPs elevated pro-fibrotic factors (TGF-β2, α-SMA and collagen I) in the kidney, and concentrations of AGEs in the intestine. The ratio of GSH and GSSG in blood was slightly reduced. Exposure to CdO NPs resulted in 10-fold higher Cd concentration in tibia bones. No differences were found in bone mass density, mineral content, bone area values, bone concentrations of Ca, P, Mg and Ca/P ratio. Our findings indicate stimulation of immune/inflammatory response, oxidative stress in the intestine, starting fibrotic response in kidneys and accumulation of CdO NPs in bones of mice." @default.
- W2982978420 created "2019-11-22" @default.
- W2982978420 creator A5001883745 @default.
- W2982978420 creator A5004075226 @default.
- W2982978420 creator A5010520406 @default.
- W2982978420 creator A5016512930 @default.
- W2982978420 creator A5029180398 @default.
- W2982978420 creator A5029271277 @default.
- W2982978420 creator A5032996809 @default.
- W2982978420 creator A5034070836 @default.
- W2982978420 creator A5036566793 @default.
- W2982978420 creator A5038069408 @default.
- W2982978420 creator A5038554020 @default.
- W2982978420 creator A5040974336 @default.
- W2982978420 creator A5044267450 @default.
- W2982978420 creator A5058904883 @default.
- W2982978420 creator A5059864807 @default.
- W2982978420 creator A5060876870 @default.
- W2982978420 creator A5061798729 @default.
- W2982978420 creator A5064036179 @default.
- W2982978420 creator A5070192976 @default.
- W2982978420 creator A5087331143 @default.
- W2982978420 creator A5090202416 @default.
- W2982978420 creator A5090613351 @default.
- W2982978420 creator A5090817738 @default.
- W2982978420 creator A5091690730 @default.
- W2982978420 date "2020-02-01" @default.
- W2982978420 modified "2023-10-17" @default.
- W2982978420 title "Six-week inhalation of CdO nanoparticles in mice: The effects on immune response, oxidative stress, antioxidative defense, fibrotic response, and bones" @default.
- W2982978420 cites W1564868321 @default.
- W2982978420 cites W1829211125 @default.
- W2982978420 cites W1949184754 @default.
- W2982978420 cites W1965243648 @default.
- W2982978420 cites W1965865448 @default.
- W2982978420 cites W1969226831 @default.
- W2982978420 cites W1977019333 @default.
- W2982978420 cites W1980449412 @default.
- W2982978420 cites W1983947492 @default.
- W2982978420 cites W1987202454 @default.
- W2982978420 cites W1992841145 @default.
- W2982978420 cites W2006370393 @default.
- W2982978420 cites W2007064404 @default.
- W2982978420 cites W2008172468 @default.
- W2982978420 cites W2010617283 @default.
- W2982978420 cites W2010728661 @default.
- W2982978420 cites W2016053535 @default.
- W2982978420 cites W2016906423 @default.
- W2982978420 cites W2023920135 @default.
- W2982978420 cites W2025785495 @default.
- W2982978420 cites W2026962733 @default.
- W2982978420 cites W2030505518 @default.
- W2982978420 cites W2034492460 @default.
- W2982978420 cites W2042641359 @default.
- W2982978420 cites W2043212102 @default.
- W2982978420 cites W2047272798 @default.
- W2982978420 cites W2051484165 @default.
- W2982978420 cites W2053487466 @default.
- W2982978420 cites W2061412878 @default.
- W2982978420 cites W2075132117 @default.
- W2982978420 cites W2079244246 @default.
- W2982978420 cites W2085076607 @default.
- W2982978420 cites W2102069080 @default.
- W2982978420 cites W2117482844 @default.
- W2982978420 cites W2120553873 @default.
- W2982978420 cites W2143499496 @default.
- W2982978420 cites W2145747788 @default.
- W2982978420 cites W2156406953 @default.
- W2982978420 cites W2165143349 @default.
- W2982978420 cites W2171981975 @default.
- W2982978420 cites W2261214326 @default.
- W2982978420 cites W2315355124 @default.
- W2982978420 cites W2316319711 @default.
- W2982978420 cites W2408466419 @default.
- W2982978420 cites W2411185207 @default.
- W2982978420 cites W2417615270 @default.
- W2982978420 cites W2519241455 @default.
- W2982978420 cites W2519352825 @default.
- W2982978420 cites W2520209981 @default.
- W2982978420 cites W2523575999 @default.
- W2982978420 cites W2582047156 @default.
- W2982978420 cites W2592528361 @default.
- W2982978420 cites W2609367751 @default.
- W2982978420 cites W2750621843 @default.
- W2982978420 cites W2767127462 @default.
- W2982978420 cites W30503967 @default.
- W2982978420 cites W4252985727 @default.
- W2982978420 doi "https://doi.org/10.1016/j.fct.2019.110954" @default.
- W2982978420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31707033" @default.
- W2982978420 hasPublicationYear "2020" @default.
- W2982978420 type Work @default.
- W2982978420 sameAs 2982978420 @default.
- W2982978420 citedByCount "9" @default.
- W2982978420 countsByYear W29829784202020 @default.
- W2982978420 countsByYear W29829784202021 @default.
- W2982978420 countsByYear W29829784202022 @default.
- W2982978420 countsByYear W29829784202023 @default.
- W2982978420 crossrefType "journal-article" @default.
- W2982978420 hasAuthorship W2982978420A5001883745 @default.