Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983007830> ?p ?o ?g. }
- W2983007830 abstract "The neural crest is an ectodermal cell population that gives rise to over 30 cell types during vertebrate embryogenesis. These stem cells are formed at the border of the developing central nervous system and undergo extensive migration before differentiating into components of multiple tissues and organs. Neural crest formation and differentiation is a multistep process, as these cells transition through sequential regulatory states before adopting their adult phenotype. Such changes are governed by a complex gene regulatory network (GRN) that integrates environmental and cell-intrinsic inputs to regulate cell identity. Studies of neural crest cells in a variety of vertebrate models have elucidated the function and regulation of dozens of the molecular players that are part of this network. The neural crest GRN has served as a platform to explore the molecular control of multipotency, cell differentiation, and the evolution of vertebrates. In this review, we employ this genetic program as a stepping-stone to explore the architecture and the regulatory principles of developmental GRNs. We also discuss how modern genomic approaches can further expand our understanding of genetic networks in this system and others. This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Biological Mechanisms > Cell Fates Developmental Biology > Lineages Models of Systems Properties and Processes > Cellular Models." @default.
- W2983007830 created "2019-11-22" @default.
- W2983007830 creator A5015923268 @default.
- W2983007830 creator A5045857555 @default.
- W2983007830 creator A5082550238 @default.
- W2983007830 date "2019-11-08" @default.
- W2983007830 modified "2023-10-18" @default.
- W2983007830 title "Network architecture and regulatory logic in neural crest development" @default.
- W2983007830 cites W1507923114 @default.
- W2983007830 cites W1531821806 @default.
- W2983007830 cites W1547754184 @default.
- W2983007830 cites W1565566882 @default.
- W2983007830 cites W171653342 @default.
- W2983007830 cites W1894858966 @default.
- W2983007830 cites W1962036314 @default.
- W2983007830 cites W1963652662 @default.
- W2983007830 cites W1980958926 @default.
- W2983007830 cites W1982532675 @default.
- W2983007830 cites W1986755101 @default.
- W2983007830 cites W1989139670 @default.
- W2983007830 cites W1992269814 @default.
- W2983007830 cites W1992898567 @default.
- W2983007830 cites W1994125144 @default.
- W2983007830 cites W1997035797 @default.
- W2983007830 cites W1999913971 @default.
- W2983007830 cites W2004827507 @default.
- W2983007830 cites W2006417453 @default.
- W2983007830 cites W2008458502 @default.
- W2983007830 cites W2008822708 @default.
- W2983007830 cites W2009371644 @default.
- W2983007830 cites W2010916267 @default.
- W2983007830 cites W2011146811 @default.
- W2983007830 cites W2018876009 @default.
- W2983007830 cites W2021052173 @default.
- W2983007830 cites W2022873912 @default.
- W2983007830 cites W2023879953 @default.
- W2983007830 cites W2024805424 @default.
- W2983007830 cites W2026321840 @default.
- W2983007830 cites W2034224962 @default.
- W2983007830 cites W2036159004 @default.
- W2983007830 cites W2042752490 @default.
- W2983007830 cites W2043713881 @default.
- W2983007830 cites W2045665377 @default.
- W2983007830 cites W2047483387 @default.
- W2983007830 cites W2047954622 @default.
- W2983007830 cites W2048904589 @default.
- W2983007830 cites W2053068844 @default.
- W2983007830 cites W2053142260 @default.
- W2983007830 cites W2053242977 @default.
- W2983007830 cites W2054379936 @default.
- W2983007830 cites W2056208399 @default.
- W2983007830 cites W2056662897 @default.
- W2983007830 cites W2057967850 @default.
- W2983007830 cites W2059979526 @default.
- W2983007830 cites W2070815798 @default.
- W2983007830 cites W2071018297 @default.
- W2983007830 cites W2073891615 @default.
- W2983007830 cites W2075994912 @default.
- W2983007830 cites W2077720819 @default.
- W2983007830 cites W2078829750 @default.
- W2983007830 cites W2080247229 @default.
- W2983007830 cites W2082823525 @default.
- W2983007830 cites W2084332810 @default.
- W2983007830 cites W2086538740 @default.
- W2983007830 cites W2088120545 @default.
- W2983007830 cites W2100331382 @default.
- W2983007830 cites W2102047286 @default.
- W2983007830 cites W2105768185 @default.
- W2983007830 cites W2109204248 @default.
- W2983007830 cites W2123140235 @default.
- W2983007830 cites W2124805860 @default.
- W2983007830 cites W2129795133 @default.
- W2983007830 cites W2131210947 @default.
- W2983007830 cites W2134374915 @default.
- W2983007830 cites W2135852310 @default.
- W2983007830 cites W2136657690 @default.
- W2983007830 cites W2137988411 @default.
- W2983007830 cites W2144172863 @default.
- W2983007830 cites W2146982581 @default.
- W2983007830 cites W2148944713 @default.
- W2983007830 cites W2149720418 @default.
- W2983007830 cites W2151794037 @default.
- W2983007830 cites W2153803157 @default.
- W2983007830 cites W2156072244 @default.
- W2983007830 cites W2159522663 @default.
- W2983007830 cites W2163010775 @default.
- W2983007830 cites W2165625463 @default.
- W2983007830 cites W2166012954 @default.
- W2983007830 cites W2166604240 @default.
- W2983007830 cites W2167620803 @default.
- W2983007830 cites W2223371815 @default.
- W2983007830 cites W2289318311 @default.
- W2983007830 cites W2295788139 @default.
- W2983007830 cites W2317488771 @default.
- W2983007830 cites W2470296318 @default.
- W2983007830 cites W2529994901 @default.
- W2983007830 cites W2562443513 @default.
- W2983007830 cites W2592875818 @default.
- W2983007830 cites W2600723790 @default.
- W2983007830 cites W2623585200 @default.