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- W2983018066 endingPage "113698" @default.
- W2983018066 startingPage "113698" @default.
- W2983018066 abstract "Chronic myeloid leukemia (CML) is a hematological disorder caused by the oncogenic BCR-ABL fusion protein in more than 90% of patients. Despite the striking improvements in the management of CML patients since the introduction of tyrosine kinase inhibitors (TKis), the appearance of TKi resistance and side effects lead to treatment failure, justifying the need of novel therapeutic approaches. Histone deacetylase inhibitors (HDACis), able to modulate gene expression patterns and important cellular signaling pathways through the regulation of the acetylation status of both histone and non-histone protein targets, have been reported to display promising anti-leukemic properties alone or in combination with TKis. This review summarizes pre-clinical and clinical studies that investigated the mechanisms underlying the anticancer potential of HDACis and discusses the rationale for a combination of HDACis with TKis as a therapeutic option in CML." @default.
- W2983018066 created "2019-11-22" @default.
- W2983018066 creator A5018593253 @default.
- W2983018066 creator A5020990482 @default.
- W2983018066 creator A5049285248 @default.
- W2983018066 creator A5067297017 @default.
- W2983018066 date "2020-03-01" @default.
- W2983018066 modified "2023-10-13" @default.
- W2983018066 title "Epigenetic mechanisms underlying the therapeutic effects of HDAC inhibitors in chronic myeloid leukemia" @default.
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