FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983042783> ?p ?o ?g. }

• W2983042783 endingPage "513" @default.
• W2983042783 startingPage "503" @default.
• W2983042783 abstract "Background: Human IL-32 is a polyfunctional cytokine that was initially reported to inhibit HIV-1 infection. However, recent data suggest that IL-32 may enhance HIV-1 replication by activating the HIV-1 primary targets, CD4 + T-cells. Indeed, IL-32 is expressed in multiple isoforms, some of which are proinflammatory, whereas others are anti-inflammatory. Setting and Methods: Here, we aimed to determine the relative expression of IL-32 isoforms and to test their inflammatory nature and potential to induce HIV-1 production in latently infected cells from virologically suppressed HIV-infected individuals. IL-32 and other cytokines were quantified from plasma and supernatant of CD4 + T-cells by ELISA. Transcripts of IL-32 isoforms were quantified by qRT-PCR in peripheral blood mononuclear cells. The impact of recombinant human IL-32 isoforms on HIV-1 transcription was assessed in CD4 + T-cells from HIV-1 + cART + individuals by qRT-PCR. Results: All IL-32 isoforms were significantly upregulated in HIV-1 + cART + compared to HIV neg individuals with IL-32β representing the dominantly expressed isoform, mainly in T-cells and NK-cells. At the functional level, although IL-32γ induced typical proinflammatory cytokines (IL-6 and IFN-γ) in TCR-activated CD4 + T-cells, IL-32α showed an anti-inflammatory profile by inducing IL-10 but not IL-6 or IFN-γ. However, IL-32β showed a dual phenotype by inducing both pro- and anti-inflammatory cytokines. Interestingly, consistent with its highly pro-inflammatory nature, IL-32γ, but not IL-32α or IL-32β, induced HIV-1 production in latently infected CD4 + T-cells isolated from combined antiretroviral therapy–treated individuals. Conclusions: Our data report on the differential expression of IL-32 isoforms and highlight the potential role of IL-32, particularly the γ isoform, in fueling persistent inflammation and transcription of viral reservoir in HIV-1 infection." @default.
• W2983042783 created "2019-11-22" @default.
• W2983042783 creator A5002635966 @default.
• W2983042783 creator A5003793199 @default.
• W2983042783 creator A5011029940 @default.
• W2983042783 creator A5012588553 @default.
• W2983042783 creator A5016102389 @default.
• W2983042783 creator A5020475843 @default.
• W2983042783 creator A5022152362 @default.
• W2983042783 creator A5024082305 @default.
• W2983042783 creator A5036431603 @default.
• W2983042783 creator A5038607718 @default.
• W2983042783 creator A5039484902 @default.
• W2983042783 creator A5041515991 @default.
• W2983042783 creator A5046760367 @default.
• W2983042783 creator A5046881942 @default.
• W2983042783 creator A5048076117 @default.
• W2983042783 creator A5057053998 @default.
• W2983042783 creator A5058582987 @default.
• W2983042783 creator A5061614395 @default.
• W2983042783 creator A5065911011 @default.
• W2983042783 creator A5067324604 @default.
• W2983042783 creator A5070026019 @default.
• W2983042783 creator A5079312171 @default.
• W2983042783 creator A5081899701 @default.
• W2983042783 creator A5083511168 @default.
• W2983042783 creator A5090310102 @default.
• W2983042783 date "2019-12-15" @default.
• W2983042783 modified "2023-10-18" @default.
• W2983042783 title "Upregulation of IL-32 Isoforms in Virologically Suppressed HIV-Infected Individuals: Potential Role in Persistent Inflammation and Transcription From Stable HIV-1 Reservoirs" @default.
• W2983042783 cites W1555146734 @default.
• W2983042783 cites W1853667775 @default.
• W2983042783 cites W1891864035 @default.
• W2983042783 cites W1948783774 @default.
• W2983042783 cites W1954697740 @default.
• W2983042783 cites W1964008166 @default.
• W2983042783 cites W1967686662 @default.
• W2983042783 cites W1979771336 @default.
• W2983042783 cites W1981023316 @default.
• W2983042783 cites W2047220571 @default.
• W2983042783 cites W2055243308 @default.
• W2983042783 cites W2063594955 @default.
• W2983042783 cites W2065958240 @default.
• W2983042783 cites W2070036973 @default.
• W2983042783 cites W2070579245 @default.
• W2983042783 cites W2073999461 @default.
• W2983042783 cites W2075090055 @default.
• W2983042783 cites W2082510200 @default.
• W2983042783 cites W2088235773 @default.
• W2983042783 cites W2089282388 @default.
• W2983042783 cites W2110558548 @default.
• W2983042783 cites W2124114936 @default.
• W2983042783 cites W2124392720 @default.
• W2983042783 cites W2125070883 @default.
• W2983042783 cites W2132813747 @default.
• W2983042783 cites W2134880528 @default.
• W2983042783 cites W2159514218 @default.
• W2983042783 cites W2161074777 @default.
• W2983042783 cites W2275878186 @default.
• W2983042783 cites W2339109475 @default.
• W2983042783 cites W2520282616 @default.
• W2983042783 cites W2544435890 @default.
• W2983042783 cites W2588239649 @default.
• W2983042783 cites W2734299438 @default.
• W2983042783 cites W2755497313 @default.
• W2983042783 cites W2790372871 @default.
• W2983042783 cites W2792699585 @default.
• W2983042783 cites W2796503167 @default.
• W2983042783 cites W2801073759 @default.
• W2983042783 cites W2801331080 @default.
• W2983042783 doi "https://doi.org/10.1097/qai.0000000000002185" @default.
• W2983042783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6857723" @default.
• W2983042783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31714430" @default.
• W2983042783 hasPublicationYear "2019" @default.
• W2983042783 type Work @default.
• W2983042783 sameAs 2983042783 @default.
• W2983042783 citedByCount "19" @default.
• W2983042783 countsByYear W29830427832020 @default.
• W2983042783 countsByYear W29830427832021 @default.
• W2983042783 countsByYear W29830427832022 @default.
• W2983042783 countsByYear W29830427832023 @default.
• W2983042783 crossrefType "journal-article" @default.
• W2983042783 hasAuthorship W2983042783A5002635966 @default.
• W2983042783 hasAuthorship W2983042783A5003793199 @default.
• W2983042783 hasAuthorship W2983042783A5011029940 @default.
• W2983042783 hasAuthorship W2983042783A5012588553 @default.
• W2983042783 hasAuthorship W2983042783A5016102389 @default.
• W2983042783 hasAuthorship W2983042783A5020475843 @default.
• W2983042783 hasAuthorship W2983042783A5022152362 @default.
• W2983042783 hasAuthorship W2983042783A5024082305 @default.
• W2983042783 hasAuthorship W2983042783A5036431603 @default.
• W2983042783 hasAuthorship W2983042783A5038607718 @default.
• W2983042783 hasAuthorship W2983042783A5039484902 @default.
• W2983042783 hasAuthorship W2983042783A5041515991 @default.
• W2983042783 hasAuthorship W2983042783A5046760367 @default.
• W2983042783 hasAuthorship W2983042783A5046881942 @default.
• W2983042783 hasAuthorship W2983042783A5048076117 @default.
• W2983042783 hasAuthorship W2983042783A5057053998 @default.

• next