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• W2983118051 abstract "Astrocytes are now known to play crucial roles in the central nervous system, supporting and closely interacting with neurons and therefore able to modulate brain function. Both human postmortem studies in brain samples from patients diagnosed with Major Depressive Disorder and from animal models of depression reported numerical and morphological astrocytic changes specifically in the hippocampus. In particular, these studies revealed significant reductions in glial cell density denoted by a decreased number of S100B-positive cells and a decrease in GFAP expression in several brain regions including the hippocampus. To reveal plastic astrocytic changes in the context of recurrent depression, we longitudinally assessed dynamic astrocytic alterations (gene expression, cell densities and morphologic variations) in the hippocampal dentate gyrus under repeated exposure to unpredictable chronic mild stress (uCMS) and upon treatment with two antidepressants, fluoxetine and imipramine. Both antidepressants decreased astrocytic complexity immediately after stress exposure. Moreover, we show that astrocytic alterations, particularly an increased number of S100B-positive cells, are observed after recurrent stress exposure. Interestingly, these alterations were prevented at the long-term by either fluoxetine or imipramine treatment." @default.
• W2983118051 created "2019-11-22" @default.
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• W2983118051 date "2021-02-01" @default.
• W2983118051 modified "2023-10-18" @default.
• W2983118051 title "Astrocytic plasticity at the dorsal dentate gyrus on an animal model of recurrent depression" @default.
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• W2983118051 doi "https://doi.org/10.1016/j.neuroscience.2019.10.032" @default.
• W2983118051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31747562" @default.
• W2983118051 hasPublicationYear "2021" @default.
• W2983118051 type Work @default.

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