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• W2983164957 abstract "ABSTRACT Catastrophic arrhythmias and sudden cardiac death can occur with even a small imbalance between inward sodium currents and outward potassium currents, but mechanisms establishing this critical balance are not understood. Here, we show that mRNA transcripts encoding I Na and I Kr channels ( SCN5A and hERG , respectively) are associated in defined complexes during protein translation. Using biochemical, electrophysiological and single-molecule fluorescence localization approaches, we find that roughly half the hERG translational complexes contain SCN5A transcripts. Moreover, the transcripts are regulated in a way that alters functional expression of both channels at the membrane. Association and coordinate regulation of transcripts in discrete “microtranslatomes” represents a new paradigm controlling electrical activity in heart and other excitable tissues." @default.
• W2983164957 created "2019-11-22" @default.
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• W2983164957 date "2019-10-21" @default.
• W2983164957 modified "2023-10-12" @default.
• W2983164957 title "A microtranslatome coordinately regulates sodium and potassium currents in the heart" @default.
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• W2983164957 doi "https://doi.org/10.1101/813592" @default.
• W2983164957 hasPublicationYear "2019" @default.
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