Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983173407> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2983173407 abstract "Cervical cancer is the second most common female cancer in The Gambia, and there have been few studies carried out on the causative agent, human papillomavirus (HPV) in this country. The Gambia introduced the quadrivalent HPV vaccine for girls between the ages of 9-13 years in the urban area in 2014; nationwide immunization will take place in 2019. This study determined the common circulating oncogenic HPV types in the urban region where most cervical cancer cases were reported. Two hundred and thirty-two women between 20 – 49 years of age from the urban region who attended a polyclinic were recruited for this work.Endocervical and high vaginal swabs were collected, and a socio-demographic questionnaire was administered to capture potential risk characteristics associated with HPV. Nucleic acid amplification techniques and DNA sequencing were carried out to determine the HPV genotype using PGMY09/11 consensus primers. Phylogenetic analysis was carried out on the Gambian HPV sequences to further confirm the identification of The Gambian HPV genotypes and its relatedness to sequences of the same types from other geographical locations. Microbiological and nucleic acid amplification analyses were used to determine the prevalence of other sexually transmitted pathogens in the participants. Blood samples, endocervical swab, and Pap smear were collected from HIV positive participants and these participants were followed up and re-examined every nine months for 24 months, to determine the persistence of cervical HPV infection, HPV antibodies, and cytological cervical changes. Pseudo-typed neutralisation assays were performed to characterise high-risk HPV antibodies in HIV positive women.Among the sample population studied, HPV prevalence was found to be 12% (28/232). HPV 52 was the most prevalent (17.9%) genotype detected in cervical samples. The Gambian high-risk HPV genotypes, except for a novel putative HPV 35 genotype, were 98 -100% identical to those submitted in the GenBank database. Prolonged (> 5 years) use of hormone contraceptive was the only variable found to associate statistically with HPV infection. Fifty percent (14/28) of participants infected with HPV were co-infected with Ureaplasma urealyticum/parvum and 25% (7/28) with HIV. HPV sero-prevalence was found to be 51.7% (15/29) in HIV positive participants. HIV positive women had been exposed to multiple HPV types and HPV 52 antibody was more prevalent 24% (7/29). Other high-risk HPV genotypes were found to cause high-grade cervical lesions and cancer in HIV positive women. Future studies to investigate oncogenic HPV genotypes in cervical cancer specimens will be useful in providing evidence for policies and future evaluation of the quadrivalent HPV vaccine in The Gambia." @default.
- W2983173407 created "2019-11-22" @default.
- W2983173407 creator A5076636633 @default.
- W2983173407 date "2018-01-01" @default.
- W2983173407 modified "2023-09-27" @default.
- W2983173407 title "Human papillomavirus genotype distribution and co-infection with sexually transmitted pathogens in reproductive age women in urban Gambia" @default.
- W2983173407 hasPublicationYear "2018" @default.
- W2983173407 type Work @default.
- W2983173407 sameAs 2983173407 @default.
- W2983173407 citedByCount "0" @default.
- W2983173407 crossrefType "dissertation" @default.
- W2983173407 hasAuthorship W2983173407A5076636633 @default.
- W2983173407 hasConcept C104317684 @default.
- W2983173407 hasConcept C121608353 @default.
- W2983173407 hasConcept C126322002 @default.
- W2983173407 hasConcept C131872663 @default.
- W2983173407 hasConcept C135763542 @default.
- W2983173407 hasConcept C159047783 @default.
- W2983173407 hasConcept C203014093 @default.
- W2983173407 hasConcept C2778220009 @default.
- W2983173407 hasConcept C2778580637 @default.
- W2983173407 hasConcept C2780009117 @default.
- W2983173407 hasConcept C29456083 @default.
- W2983173407 hasConcept C2994532551 @default.
- W2983173407 hasConcept C54355233 @default.
- W2983173407 hasConcept C71924100 @default.
- W2983173407 hasConcept C86803240 @default.
- W2983173407 hasConceptScore W2983173407C104317684 @default.
- W2983173407 hasConceptScore W2983173407C121608353 @default.
- W2983173407 hasConceptScore W2983173407C126322002 @default.
- W2983173407 hasConceptScore W2983173407C131872663 @default.
- W2983173407 hasConceptScore W2983173407C135763542 @default.
- W2983173407 hasConceptScore W2983173407C159047783 @default.
- W2983173407 hasConceptScore W2983173407C203014093 @default.
- W2983173407 hasConceptScore W2983173407C2778220009 @default.
- W2983173407 hasConceptScore W2983173407C2778580637 @default.
- W2983173407 hasConceptScore W2983173407C2780009117 @default.
- W2983173407 hasConceptScore W2983173407C29456083 @default.
- W2983173407 hasConceptScore W2983173407C2994532551 @default.
- W2983173407 hasConceptScore W2983173407C54355233 @default.
- W2983173407 hasConceptScore W2983173407C71924100 @default.
- W2983173407 hasConceptScore W2983173407C86803240 @default.
- W2983173407 hasLocation W29831734071 @default.
- W2983173407 hasOpenAccess W2983173407 @default.
- W2983173407 hasPrimaryLocation W29831734071 @default.
- W2983173407 hasRelatedWork W1532588442 @default.
- W2983173407 hasRelatedWork W1768976969 @default.
- W2983173407 hasRelatedWork W2081777848 @default.
- W2983173407 hasRelatedWork W2094228272 @default.
- W2983173407 hasRelatedWork W2115583200 @default.
- W2983173407 hasRelatedWork W2117554134 @default.
- W2983173407 hasRelatedWork W2140121350 @default.
- W2983173407 hasRelatedWork W2165008049 @default.
- W2983173407 hasRelatedWork W2405098607 @default.
- W2983173407 hasRelatedWork W2409757272 @default.
- W2983173407 hasRelatedWork W2605969652 @default.
- W2983173407 hasRelatedWork W2784760050 @default.
- W2983173407 hasRelatedWork W2852883568 @default.
- W2983173407 hasRelatedWork W2896303276 @default.
- W2983173407 hasRelatedWork W2981642889 @default.
- W2983173407 hasRelatedWork W3008257617 @default.
- W2983173407 hasRelatedWork W3034455008 @default.
- W2983173407 hasRelatedWork W3190157835 @default.
- W2983173407 hasRelatedWork W3200534133 @default.
- W2983173407 hasRelatedWork W3197085673 @default.
- W2983173407 isParatext "false" @default.
- W2983173407 isRetracted "false" @default.
- W2983173407 magId "2983173407" @default.
- W2983173407 workType "dissertation" @default.