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- W2983177025 abstract "The ability of self-replicating oncolytic viruses (OVs) to preferentially infect and lyse cancer cells while stimulating anti-tumour immunity of the host strongly indicates its value as a new field of cancer therapeutics to be further explored. The emergence of Zika virus (ZIKV) as a global health threat due to its recent outbreak in Brazil has caught the attention of the scientific community and led to the discovery of its oncolytic potential for the treatment of glioblastoma multiforme (GBM), the most common and fatal brain tumour with poor prognosis. Herein, we evaluate the neurotropism of ZIKV relative to the receptor tyrosine kinase AXL and its ligand Gas6 in viral entry and the RNA-binding protein Musashi-1 (MSI1) in replication which are also overexpressed in GBM, suggesting its potential for specific targeting of the tumour. Additionally, this review discusses genetic modifications performed to enhance safety and efficacy of ZIKV as well as speculates future directions for the OV therapy." @default.
- W2983177025 created "2019-11-22" @default.
- W2983177025 creator A5060825406 @default.
- W2983177025 creator A5072743037 @default.
- W2983177025 date "2019-11-20" @default.
- W2983177025 modified "2023-09-30" @default.
- W2983177025 title "Zika Virus as Oncolytic Therapy for Brain Cancer: Myth or Reality?" @default.
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- W2983177025 doi "https://doi.org/10.3389/fmicb.2019.02715" @default.
- W2983177025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6879458" @default.
- W2983177025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31824472" @default.
- W2983177025 hasPublicationYear "2019" @default.
- W2983177025 type Work @default.
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