Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983196129> ?p ?o ?g. }
- W2983196129 endingPage "101331" @default.
- W2983196129 startingPage "101331" @default.
- W2983196129 abstract "Glomerulonephritis (GN) refers to a group of renal diseases affecting the glomeruli due to the damage mediated by immunological mechanisms. A large proportion of the disease manifestations are caused by disturbances in the complement system. They can be due to genetic errors, autoimmunity, microbes or abnormal immunoglobulins, like modified IgA or paraproteins. The common denominator in most of the problems is an overactive or misdirected alternative pathway complement activation. An assessment of kidney function, amount of proteinuria and hematuria are crucial elements to evaluate, when glomerulonephritis is suspected. However, the cornerstones of the diagnoses are renal biopsy and careful examination of the complement abnormality. Differential diagnostics between the various forms of GN is not possible based on clinical features, as they may vary greatly. This review describes the known mechanisms of complement dysfunction leading to different forms of primary GN (like IgA glomerulonephritis, dense deposit disease, C3 glomerulonephritis, post-infectious GN, membranous GN) and differences to atypical hemolytic uremic syndrome. It also covers the basic elements of etiology-directed therapy and prognosis of the most common forms of GN. Common principles in the management of GN include treatment of hypertension and reduction of proteinuria, some require immunomodulating treatment. Complement inhibition is an emerging treatment option. A thorough understanding of the basic disease mechanism and a careful follow-up are needed for optimal therapy." @default.
- W2983196129 created "2019-11-22" @default.
- W2983196129 creator A5018299262 @default.
- W2983196129 creator A5025820462 @default.
- W2983196129 creator A5043783878 @default.
- W2983196129 creator A5080377718 @default.
- W2983196129 creator A5065648688 @default.
- W2983196129 date "2019-10-01" @default.
- W2983196129 modified "2023-10-15" @default.
- W2983196129 title "Complement dysregulation in glomerulonephritis" @default.
- W2983196129 cites W1535259997 @default.
- W2983196129 cites W1554698729 @default.
- W2983196129 cites W1569990619 @default.
- W2983196129 cites W1588659088 @default.
- W2983196129 cites W1966590389 @default.
- W2983196129 cites W1968635717 @default.
- W2983196129 cites W1976386747 @default.
- W2983196129 cites W1982872424 @default.
- W2983196129 cites W1987377311 @default.
- W2983196129 cites W1988891719 @default.
- W2983196129 cites W1990148510 @default.
- W2983196129 cites W1997599954 @default.
- W2983196129 cites W2010887039 @default.
- W2983196129 cites W2011498897 @default.
- W2983196129 cites W2014937730 @default.
- W2983196129 cites W2017568050 @default.
- W2983196129 cites W2026447286 @default.
- W2983196129 cites W2026527112 @default.
- W2983196129 cites W2028585463 @default.
- W2983196129 cites W2029886021 @default.
- W2983196129 cites W2034894407 @default.
- W2983196129 cites W2036607489 @default.
- W2983196129 cites W2036694775 @default.
- W2983196129 cites W2038181025 @default.
- W2983196129 cites W2046427044 @default.
- W2983196129 cites W2053128888 @default.
- W2983196129 cites W2053633351 @default.
- W2983196129 cites W2056583648 @default.
- W2983196129 cites W2057680172 @default.
- W2983196129 cites W2060987046 @default.
- W2983196129 cites W2063874378 @default.
- W2983196129 cites W2067136804 @default.
- W2983196129 cites W2070569398 @default.
- W2983196129 cites W2072417552 @default.
- W2983196129 cites W2074855979 @default.
- W2983196129 cites W2077144266 @default.
- W2983196129 cites W2079648119 @default.
- W2983196129 cites W2083760961 @default.
- W2983196129 cites W2087734464 @default.
- W2983196129 cites W2087844463 @default.
- W2983196129 cites W2093780976 @default.
- W2983196129 cites W2097173937 @default.
- W2983196129 cites W2098315002 @default.
- W2983196129 cites W2100894499 @default.
- W2983196129 cites W2108789237 @default.
- W2983196129 cites W2125341483 @default.
- W2983196129 cites W2126299539 @default.
- W2983196129 cites W2134800117 @default.
- W2983196129 cites W2135400491 @default.
- W2983196129 cites W2139588645 @default.
- W2983196129 cites W2141275524 @default.
- W2983196129 cites W2144737888 @default.
- W2983196129 cites W2147835734 @default.
- W2983196129 cites W2157232297 @default.
- W2983196129 cites W2162002618 @default.
- W2983196129 cites W2162337442 @default.
- W2983196129 cites W2164395407 @default.
- W2983196129 cites W2164401685 @default.
- W2983196129 cites W2166822765 @default.
- W2983196129 cites W2167821466 @default.
- W2983196129 cites W2198719354 @default.
- W2983196129 cites W2212745154 @default.
- W2983196129 cites W2221077721 @default.
- W2983196129 cites W2284643917 @default.
- W2983196129 cites W2309371657 @default.
- W2983196129 cites W2400921333 @default.
- W2983196129 cites W2484733150 @default.
- W2983196129 cites W2516815671 @default.
- W2983196129 cites W2523069877 @default.
- W2983196129 cites W2531565737 @default.
- W2983196129 cites W2532400747 @default.
- W2983196129 cites W2565152113 @default.
- W2983196129 cites W2586394131 @default.
- W2983196129 cites W2602196428 @default.
- W2983196129 cites W2617482626 @default.
- W2983196129 cites W2625366743 @default.
- W2983196129 cites W2738059167 @default.
- W2983196129 cites W2747145552 @default.
- W2983196129 cites W2767003335 @default.
- W2983196129 cites W2768879882 @default.
- W2983196129 cites W2804942357 @default.
- W2983196129 cites W2807577773 @default.
- W2983196129 cites W2808872936 @default.
- W2983196129 cites W2885871278 @default.
- W2983196129 cites W2902739495 @default.
- W2983196129 cites W2910019464 @default.
- W2983196129 cites W2914604561 @default.
- W2983196129 cites W2915966197 @default.