FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983289425> ?p ?o ?g. }

• W2983289425 endingPage "104665" @default.
• W2983289425 startingPage "104665" @default.
• W2983289425 abstract "Sympathetic dysfunction is suggested to contribute to development of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of microglia in development/resolution of neuroinflammation, contribution of noradrenaline, the key sympathetic end-point mediator, in modulation of microglial phenotypic and functional properties in rat EAE model was examined. The study showed that noradrenaline acting in neurocrine and autocrine/paracrine way might influence microglia during EAE. Propranolol treatment over the effector phase moderated EAE course. This was associated with the increased proportion of microglia expressing CX3CR1, the key molecule in their immunomodulatory/neuroprotective action, and upregulation of CX3CR1 downstream Nrf2 gene. This correlated with the increased heme oxygenase-1 (HO-1) expression and phagocytic capacity of microglia, and their phenotypic changes mirrored in increased proportion of CD163- and CD83-expressing cells. The enhanced HO-1 expression was linked with the decreased proportion of microglial cells expressing IL-1β and IL-23, and possibly IL-6, followed by increased proportion of IL-10–expressing microglia, and downregulated MCP-1/CCL2 expression. Consistently, spinal cord infiltration with blood-borne myeloid and CD4+ T cells, as well as CD4+ T-cell reactivation/proliferation and differentiation into highly pathogenic IL-17+ cells co-producing IFN-γ and GM-CSF were decreased in propranolol-treated rats compared with saline-injected controls. The in vitro investigations of the effects of noradrenaline on microglia showed that noradrenaline through β-adrenoceptor may influence Nrf2 expression also via CX3CR1-independent route. The study suggests β-adrenoceptor–mediated neuroinflammation-promoting role of noradrenaline in EAE via modulation of microglial Nrf2 expression, and thereby forms the basis for further translational pharmacological research to improve multiple sclerosis therapy." @default.
• W2983289425 created "2019-11-22" @default.
• W2983289425 creator A5008604436 @default.
• W2983289425 creator A5033930255 @default.
• W2983289425 creator A5043388647 @default.
• W2983289425 creator A5056521919 @default.
• W2983289425 creator A5077388695 @default.
• W2983289425 date "2020-02-01" @default.
• W2983289425 modified "2023-09-30" @default.
• W2983289425 title "Propranolol diminished severity of rat EAE by enhancing immunoregulatory/protective properties of spinal cord microglia" @default.
• W2983289425 cites W1523338791 @default.
• W2983289425 cites W1610351097 @default.
• W2983289425 cites W1697354033 @default.
• W2983289425 cites W1906704201 @default.
• W2983289425 cites W1963664876 @default.
• W2983289425 cites W1966800073 @default.
• W2983289425 cites W1968948468 @default.
• W2983289425 cites W1970120310 @default.
• W2983289425 cites W1973968129 @default.
• W2983289425 cites W1978597946 @default.
• W2983289425 cites W1979550092 @default.
• W2983289425 cites W1983854643 @default.
• W2983289425 cites W1990088296 @default.
• W2983289425 cites W1993167331 @default.
• W2983289425 cites W1993341098 @default.
• W2983289425 cites W1997517677 @default.
• W2983289425 cites W1998348881 @default.
• W2983289425 cites W1999579326 @default.
• W2983289425 cites W2006237279 @default.
• W2983289425 cites W2007229760 @default.
• W2983289425 cites W2009347061 @default.
• W2983289425 cites W2012992125 @default.
• W2983289425 cites W2015270042 @default.
• W2983289425 cites W2015347941 @default.
• W2983289425 cites W2018084738 @default.
• W2983289425 cites W2019679882 @default.
• W2983289425 cites W2020941408 @default.
• W2983289425 cites W2023464373 @default.
• W2983289425 cites W2025301583 @default.
• W2983289425 cites W2026430918 @default.
• W2983289425 cites W2028836722 @default.
• W2983289425 cites W2029366460 @default.
• W2983289425 cites W2029628152 @default.
• W2983289425 cites W2034761064 @default.
• W2983289425 cites W2038926224 @default.
• W2983289425 cites W2042472185 @default.
• W2983289425 cites W2042808596 @default.
• W2983289425 cites W2043299701 @default.
• W2983289425 cites W2043646473 @default.
• W2983289425 cites W2047570180 @default.
• W2983289425 cites W2050907042 @default.
• W2983289425 cites W2053646585 @default.
• W2983289425 cites W2054685256 @default.
• W2983289425 cites W2058021161 @default.
• W2983289425 cites W2058907654 @default.
• W2983289425 cites W2059704497 @default.
• W2983289425 cites W2063375252 @default.
• W2983289425 cites W2067678609 @default.
• W2983289425 cites W2070447896 @default.
• W2983289425 cites W2072857979 @default.
• W2983289425 cites W2072895957 @default.
• W2983289425 cites W2073091737 @default.
• W2983289425 cites W2075119830 @default.
• W2983289425 cites W2077895679 @default.
• W2983289425 cites W2082347869 @default.
• W2983289425 cites W2087843772 @default.
• W2983289425 cites W2087963988 @default.
• W2983289425 cites W2093534560 @default.
• W2983289425 cites W2094748532 @default.
• W2983289425 cites W2095370244 @default.
• W2983289425 cites W2096423240 @default.
• W2983289425 cites W2103274844 @default.
• W2983289425 cites W2103940027 @default.
• W2983289425 cites W2107505658 @default.
• W2983289425 cites W2117530544 @default.
• W2983289425 cites W2118508069 @default.
• W2983289425 cites W2130975342 @default.
• W2983289425 cites W2135102081 @default.
• W2983289425 cites W2135716022 @default.
• W2983289425 cites W2136368099 @default.
• W2983289425 cites W2153206087 @default.
• W2983289425 cites W2157198621 @default.
• W2983289425 cites W2158664025 @default.
• W2983289425 cites W2161456562 @default.
• W2983289425 cites W2162226607 @default.
• W2983289425 cites W2163436886 @default.
• W2983289425 cites W2164191009 @default.
• W2983289425 cites W2167748768 @default.
• W2983289425 cites W2170543217 @default.
• W2983289425 cites W2171840395 @default.
• W2983289425 cites W2272972580 @default.
• W2983289425 cites W2274044764 @default.
• W2983289425 cites W2552240478 @default.
• W2983289425 cites W2557174471 @default.
• W2983289425 cites W2594854995 @default.
• W2983289425 cites W2605907314 @default.
• W2983289425 cites W2697678125 @default.
• W2983289425 cites W2754890392 @default.

• next