Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983295170> ?p ?o ?g. }
- W2983295170 abstract "Abstract Nitric oxide (NO) is a gaseous signaling molecule that plays an important role in neurovascular coupling. NO produced by neurons diffuses into the smooth muscle surrounding cerebral arterioles, driving vasodilation. However, the rate of NO degradation in hemoglobin is orders of magnitude higher than in brain tissue, though how this might impact NO signaling dynamics is not completely understood. We used simulations to investigate how the spatial and temporal patterns of NO generation and degradation impacted dilation of a penetrating arteriole in cortex. We found that the spatial location of NO production and the size of the vessel both played an important role in determining its responsiveness to NO. The much higher rate of NO degradation and scavenging of NO in the blood relative to the tissue drove emergent vascular dynamics. Large vasodilation events could be followed by post-stimulus constrictions driven by the increased degradation of NO by the blood, and vasomotion-like 0.1-0.3 Hz oscillations could also be generated. We found that these dynamics could be enhanced by elevation of free hemoglobin in the plasma, which occurs in diseases such as malaria and sickle cell anemia, or following blood transfusions. Finally, we show that changes in blood flow during hypoxia or hyperoxia could be explained by altered NO degradation in the parenchyma. Our simulations suggest that many common vascular dynamics may be emergent phenomenon generated by NO degradation by the blood or parenchyma." @default.
- W2983295170 created "2019-11-22" @default.
- W2983295170 creator A5034158635 @default.
- W2983295170 creator A5038554858 @default.
- W2983295170 creator A5061351670 @default.
- W2983295170 date "2019-11-09" @default.
- W2983295170 modified "2023-09-23" @default.
- W2983295170 title "Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics" @default.
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