Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983310990> ?p ?o ?g. }
- W2983310990 endingPage "126" @default.
- W2983310990 startingPage "112" @default.
- W2983310990 abstract "Drug repositioning is an emerging approach to developing novel cancer treatments. Vorinostat is a histone deacetylase inhibitor approved for cancer treatment, but it could attenuate its anticancer activity by activating the mTOR pathway. The HMG-CoA reductase inhibitor fluvastatin reportedly activates the mTOR inhibitor AMP-activated protein kinase (AMPK), and we thought that it would potentiate vorinostat's anticancer activity in renal cancer cells. The combination of vorinostat and fluvastatin induced robust apoptosis and inhibited renal cancer growth effectively both in vitro and in vivo. Vorinostat activated the mTOR pathway, as evidenced by the phosphorylation of ribosomal protein S6, and fluvastatin inhibited this phosphorylation by activating AMPK. Fluvastatin also enhanced vorinostat-induced histone acetylation. Furthermore, the combination induced endoplasmic reticulum (ER) stress that was accompanied by aggresome formation. We also found that there was a positive feedback cycle among AMPK activation, histone acetylation, and ER stress induction. This is the first study to report the beneficial combined effect of vorinostat and fluvastatin in cancer cells." @default.
- W2983310990 created "2019-11-22" @default.
- W2983310990 creator A5030204764 @default.
- W2983310990 creator A5038413661 @default.
- W2983310990 creator A5062286797 @default.
- W2983310990 creator A5070636107 @default.
- W2983310990 creator A5090343628 @default.
- W2983310990 date "2019-11-25" @default.
- W2983310990 modified "2023-10-02" @default.
- W2983310990 title "Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells" @default.
- W2983310990 cites W1492145388 @default.
- W2983310990 cites W1511815964 @default.
- W2983310990 cites W1696892656 @default.
- W2983310990 cites W1830803900 @default.
- W2983310990 cites W1832855151 @default.
- W2983310990 cites W1948106027 @default.
- W2983310990 cites W1964296201 @default.
- W2983310990 cites W1967018540 @default.
- W2983310990 cites W1968568016 @default.
- W2983310990 cites W1975286848 @default.
- W2983310990 cites W1976298557 @default.
- W2983310990 cites W1978710394 @default.
- W2983310990 cites W1983864341 @default.
- W2983310990 cites W1987616570 @default.
- W2983310990 cites W1993376998 @default.
- W2983310990 cites W1995974102 @default.
- W2983310990 cites W1998476690 @default.
- W2983310990 cites W2006866162 @default.
- W2983310990 cites W2009437091 @default.
- W2983310990 cites W2010437021 @default.
- W2983310990 cites W2025557550 @default.
- W2983310990 cites W2031628684 @default.
- W2983310990 cites W2031954417 @default.
- W2983310990 cites W2052048865 @default.
- W2983310990 cites W2060996760 @default.
- W2983310990 cites W2066557401 @default.
- W2983310990 cites W2067019627 @default.
- W2983310990 cites W2067979493 @default.
- W2983310990 cites W2080369972 @default.
- W2983310990 cites W2083005883 @default.
- W2983310990 cites W2090296651 @default.
- W2983310990 cites W2092501359 @default.
- W2983310990 cites W2095454212 @default.
- W2983310990 cites W2096439168 @default.
- W2983310990 cites W2097254028 @default.
- W2983310990 cites W2105835610 @default.
- W2983310990 cites W2115785123 @default.
- W2983310990 cites W2118107482 @default.
- W2983310990 cites W2118667643 @default.
- W2983310990 cites W2123762244 @default.
- W2983310990 cites W2126613337 @default.
- W2983310990 cites W2131276314 @default.
- W2983310990 cites W2131612416 @default.
- W2983310990 cites W2132413659 @default.
- W2983310990 cites W2146748825 @default.
- W2983310990 cites W2147636174 @default.
- W2983310990 cites W2148303621 @default.
- W2983310990 cites W2149379768 @default.
- W2983310990 cites W2149761960 @default.
- W2983310990 cites W2151445954 @default.
- W2983310990 cites W2155421604 @default.
- W2983310990 cites W2155500949 @default.
- W2983310990 cites W2158178080 @default.
- W2983310990 cites W2162744380 @default.
- W2983310990 cites W2171141282 @default.
- W2983310990 cites W2236556634 @default.
- W2983310990 cites W2308350549 @default.
- W2983310990 cites W2413905035 @default.
- W2983310990 cites W2518084826 @default.
- W2983310990 cites W2524406283 @default.
- W2983310990 cites W2530145254 @default.
- W2983310990 cites W2558464985 @default.
- W2983310990 cites W2575804911 @default.
- W2983310990 cites W2594861736 @default.
- W2983310990 cites W2603685565 @default.
- W2983310990 cites W2617046565 @default.
- W2983310990 cites W2724336500 @default.
- W2983310990 cites W2749532423 @default.
- W2983310990 cites W2805269478 @default.
- W2983310990 cites W2887504406 @default.
- W2983310990 cites W2887831917 @default.
- W2983310990 cites W2895011240 @default.
- W2983310990 cites W2922511143 @default.
- W2983310990 doi "https://doi.org/10.1111/cas.14225" @default.
- W2983310990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6942444" @default.
- W2983310990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31675763" @default.
- W2983310990 hasPublicationYear "2019" @default.
- W2983310990 type Work @default.
- W2983310990 sameAs 2983310990 @default.
- W2983310990 citedByCount "36" @default.
- W2983310990 countsByYear W29833109902020 @default.
- W2983310990 countsByYear W29833109902021 @default.
- W2983310990 countsByYear W29833109902022 @default.
- W2983310990 countsByYear W29833109902023 @default.
- W2983310990 crossrefType "journal-article" @default.
- W2983310990 hasAuthorship W2983310990A5030204764 @default.
- W2983310990 hasAuthorship W2983310990A5038413661 @default.
- W2983310990 hasAuthorship W2983310990A5062286797 @default.