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- W2983388081 abstract "The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise can attenuate the loss of muscle mass during severe energy deficit (5500 kcal/day). Overweight men followed four days of caloric restriction (3.2 kcal/kg body weight day) and prolonged exercise (45 min of one-arm cranking and 8 h walking/day), and three days of control diet and restricted exercise, with an intra-subject design including biopsies from muscles submitted to distinct exercise volumes. Gene expression and signaling data indicate that the main catabolic pathway activated during severe energy deficit in skeletal muscle is the autophagy-lysosome pathway, without apparent activation of the ubiquitin-proteasome pathway. Markers of autophagy induction and flux were reduced by exercise primarily in the muscle submitted to an exceptional exercise volume. Changes in signaling are associated with those in circulating cortisol, testosterone, cortisol/testosterone ratio, insulin, BCAA, and leucine. We conclude that exercise mitigates the loss of muscle mass by attenuating autophagy activation, blunting the phosphorylation of AMPK/ULK1/Beclin1, and leading to p62/SQSTM1 accumulation. This includes the possibility of inhibiting autophagy as a mechanism to counteract muscle loss in humans under severe energy deficit." @default.
- W2983388081 created "2019-11-22" @default.
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- W2983388081 date "2019-11-19" @default.
- W2983388081 modified "2023-10-18" @default.
- W2983388081 title "Exercise Mitigates the Loss of Muscle Mass by Attenuating the Activation of Autophagy during Severe Energy Deficit" @default.
- W2983388081 cites W1508661542 @default.
- W2983388081 cites W1670138443 @default.
- W2983388081 cites W1783089853 @default.
- W2983388081 cites W1827024057 @default.
- W2983388081 cites W1848438685 @default.
- W2983388081 cites W1888981292 @default.
- W2983388081 cites W1955400443 @default.
- W2983388081 cites W1967644678 @default.
- W2983388081 cites W1971857747 @default.
- W2983388081 cites W1975245295 @default.
- W2983388081 cites W1991247103 @default.
- W2983388081 cites W1992643412 @default.
- W2983388081 cites W1996735611 @default.
- W2983388081 cites W1999211990 @default.
- W2983388081 cites W2002815057 @default.
- W2983388081 cites W2006908436 @default.
- W2983388081 cites W2008352037 @default.
- W2983388081 cites W2009618449 @default.
- W2983388081 cites W2016802914 @default.
- W2983388081 cites W2017596991 @default.
- W2983388081 cites W2017969831 @default.
- W2983388081 cites W2019757335 @default.
- W2983388081 cites W2024145500 @default.
- W2983388081 cites W2036787961 @default.
- W2983388081 cites W2037748892 @default.
- W2983388081 cites W2046956654 @default.
- W2983388081 cites W2048046939 @default.
- W2983388081 cites W2054594032 @default.
- W2983388081 cites W2060243818 @default.
- W2983388081 cites W2063509597 @default.
- W2983388081 cites W2065691406 @default.
- W2983388081 cites W2070068623 @default.
- W2983388081 cites W2077479928 @default.
- W2983388081 cites W2077949897 @default.
- W2983388081 cites W2079797384 @default.
- W2983388081 cites W2081092205 @default.
- W2983388081 cites W2082476985 @default.
- W2983388081 cites W2091282912 @default.
- W2983388081 cites W2098264151 @default.
- W2983388081 cites W2106883683 @default.
- W2983388081 cites W2110736978 @default.
- W2983388081 cites W2111020389 @default.
- W2983388081 cites W2115202941 @default.
- W2983388081 cites W2118723911 @default.
- W2983388081 cites W2119399459 @default.
- W2983388081 cites W2125928541 @default.
- W2983388081 cites W2126031921 @default.
- W2983388081 cites W2128583851 @default.
- W2983388081 cites W2134386671 @default.
- W2983388081 cites W2140598688 @default.
- W2983388081 cites W2142038460 @default.
- W2983388081 cites W2143239856 @default.
- W2983388081 cites W2147459821 @default.
- W2983388081 cites W2157940056 @default.
- W2983388081 cites W2167033587 @default.
- W2983388081 cites W2169448756 @default.
- W2983388081 cites W2171129594 @default.
- W2983388081 cites W2175495331 @default.
- W2983388081 cites W2179041531 @default.
- W2983388081 cites W2179609817 @default.
- W2983388081 cites W2280853449 @default.
- W2983388081 cites W2285932064 @default.
- W2983388081 cites W2286914299 @default.
- W2983388081 cites W2300960572 @default.
- W2983388081 cites W2338695699 @default.
- W2983388081 cites W2400197929 @default.
- W2983388081 cites W2469224710 @default.
- W2983388081 cites W2475012640 @default.
- W2983388081 cites W2511349034 @default.
- W2983388081 cites W2522457831 @default.
- W2983388081 cites W2527297832 @default.
- W2983388081 cites W2528703423 @default.
- W2983388081 cites W2557301418 @default.
- W2983388081 cites W2695975694 @default.
- W2983388081 cites W2728973442 @default.
- W2983388081 cites W2737344679 @default.
- W2983388081 cites W2752326209 @default.
- W2983388081 cites W2756325874 @default.
- W2983388081 cites W2765400080 @default.
- W2983388081 cites W2775532243 @default.
- W2983388081 cites W2790604423 @default.