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• W2983390147 abstract "BackgroundDue to the considerable burden of multiple sclerosis (MS)-related symptoms and the need to identify effective interventions to prevent disease progression, various nutraceutical interventions have been trialed as adjunctive treatments. The aim of this review was to investigate the efficacy and safety of nutraceutical interventions for clinical and biological outcomes in people with MS.MethodsIn accordance with PRISMA reporting guidelines, a systematic literature search was conducted using three electronic literature databases. Risk of bias was assessed using the Jadad scale.ResultsThirty-seven randomized controlled trials, investigating fourteen nutraceuticals, were included in the review. Trials that investigated alpha lipoic acid (n = 4/6), ginkgo biloba (n = 3/5), vitamin A (n = 2/2), biotin (n = 1/2), carnitine (n = 1/2), green tea (n = 1/2), coenzyme Q10 (n = 1/1), probiotics (n = 1/1), curcumin (n = 1/1), Andrographis paniculata (n = 1/1), ginseng (n = 1/1), and lemon verbena (n = 1/1) were reported to improve biological (e.g. MRI brain volume change, antioxidant capacity) and/or clinical (e.g. fatigue, depression, Expanded Disability Status Scale) outcomes in multiple sclerosis compared to control. However, most trials were relatively small (average study sample size across included studies, n = 55) and there were few replicate studies per nutraceutical to validate the reported results. Furthermore, some nutraceuticals (e.g. green tea and inosine) should be used with caution due to reported adverse events. Risk of bias across most studies was low, with 31 studies receiving a score between 4 and 5 (out of 5) on the Jadad Scale.ConclusionThe existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS. However, sufficiently powered long-term trials are required to expand the currently limited literature and to investigate unexplored nutraceuticals that may target relevant pathways involved in MS such as the gut microbiome and mitochondrial dysfunction. Prospero ID: CRD42018111736." @default.
• W2983390147 created "2019-11-22" @default.
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• W2983390147 date "2020-01-01" @default.
• W2983390147 modified "2023-10-18" @default.
• W2983390147 title "The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review" @default.
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• W2983390147 cites W1988316193 @default.
• W2983390147 cites W1991079475 @default.
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• W2983390147 cites W1995037638 @default.
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• W2983390147 cites W2014049731 @default.
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• W2983390147 cites W2031636396 @default.
• W2983390147 cites W2032395491 @default.
• W2983390147 cites W2047416003 @default.
• W2983390147 cites W2058604889 @default.
• W2983390147 cites W2072782691 @default.
• W2983390147 cites W2076001345 @default.
• W2983390147 cites W2099464873 @default.
• W2983390147 cites W2117276061 @default.
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• W2983390147 cites W2132212188 @default.
• W2983390147 cites W2147018080 @default.
• W2983390147 cites W2159205882 @default.
• W2983390147 cites W2163738265 @default.
• W2983390147 cites W2234221370 @default.
• W2983390147 cites W2343979127 @default.
• W2983390147 cites W2397056432 @default.
• W2983390147 cites W2405701543 @default.
• W2983390147 cites W2499521001 @default.
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• W2983390147 cites W2518730393 @default.
• W2983390147 cites W2552273282 @default.
• W2983390147 cites W2576144213 @default.
• W2983390147 cites W2585584183 @default.
• W2983390147 cites W2586192603 @default.
• W2983390147 cites W2725212050 @default.
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• W2983390147 cites W2802525182 @default.
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• W2983390147 doi "https://doi.org/10.1016/j.msard.2019.101486" @default.
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