FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983396687> ?p ?o ?g. }

• W2983396687 abstract "Introduction and objectives Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease that accounts for 1% of UK deaths. Causal genes have been found accounting for about 30% of familial cases of pulmonary fibrosis and the majority relate to telomere maintenance. However, no evidence of causality in the idiopathic form of the disease has yet been found. Prematurely shortened leukocyte telomere length (LTL) has been associated with IPF and also Chronic Obstructive Pulmonary Disease (COPD), a disease with a similar demographic and symptomatology. Studies have shown age adjusted LTL values of 0.85 ± 0.60 vs 1.15 ± 0.6, p=0.0001 for IPF1 and 0.68 ± 0.25 vs. 0.88 ± 0.52 (smoking controls), p = 0.003 for COPD.2 We sought to investigate causality in IPF using Mendelian randomisation (MR) with UK Biobank data. To our knowledge, this is the first genetic study of this IPF cohort and the first application of MR to investigate causality in IPF. We hypothesised that prematurely shortened telomeres are causal in IPF but not in COPD. Methods We performed one- and two-sample MR in the UK Biobank data. This study had 1,133 IPF cases (defined by ICD10 code J84.1), 11,413 COPD cases and 378,575 controls, all of European ancestry. Seven variants previously associated with telomere length were used in the MR analysis. Pleiotropy was explored using MR approaches including MR-Egger and Median MR. Results A genetically instrumented one unit LTL shorter telomere length was associated with higher odds of IPF (OR 4.19 [95%CI: 2.33–7.55], P=0.0031). Similar results were found in males and females separately. Despite being an age-related lung disease with similar symptoms, there was no evidence that telomere length caused COPD. Conclusions Prematurely shortened telomeres have a likely causal effect in IPF. This enables a greater focus on telomere-related diagnostics, treatments and the search for a cure. Safe telomere activation therapy is being explored in the cardiology field, amongst others, using transient delivery of telomerase and there are also accessible therapies that show improved telomere length. Such approaches warrant investigation in IPF. References Dai, J., et al. Respirology, 2015. Rode, L., et al. Thorax, 2013." @default.
• W2983396687 created "2019-11-22" @default.
• W2983396687 creator A5000154293 @default.
• W2983396687 creator A5006177946 @default.
• W2983396687 creator A5041764156 @default.
• W2983396687 creator A5046230847 @default.
• W2983396687 creator A5063525602 @default.
• W2983396687 creator A5076198914 @default.
• W2983396687 creator A5086719422 @default.
• W2983396687 date "2019-11-12" @default.
• W2983396687 modified "2023-09-27" @default.
• W2983396687 title "S67 Evidence that telomere length is causal for idiopathic pulmonary fibrosis but not chronic obstructive pulmonary disease: a UK biobank mendelian randomisation study" @default.
• W2983396687 doi "https://doi.org/10.1136/thorax-2019-btsabstracts2019.73" @default.
• W2983396687 hasPublicationYear "2019" @default.
• W2983396687 type Work @default.
• W2983396687 sameAs 2983396687 @default.
• W2983396687 citedByCount "0" @default.
• W2983396687 crossrefType "proceedings-article" @default.
• W2983396687 hasAuthorship W2983396687A5000154293 @default.
• W2983396687 hasAuthorship W2983396687A5006177946 @default.
• W2983396687 hasAuthorship W2983396687A5041764156 @default.
• W2983396687 hasAuthorship W2983396687A5046230847 @default.
• W2983396687 hasAuthorship W2983396687A5063525602 @default.
• W2983396687 hasAuthorship W2983396687A5076198914 @default.
• W2983396687 hasAuthorship W2983396687A5086719422 @default.
• W2983396687 hasConcept C116567970 @default.
• W2983396687 hasConcept C126322002 @default.
• W2983396687 hasConcept C142724271 @default.
• W2983396687 hasConcept C156957248 @default.
• W2983396687 hasConcept C177336024 @default.
• W2983396687 hasConcept C2776780178 @default.
• W2983396687 hasConcept C2777714996 @default.
• W2983396687 hasConcept C2778341716 @default.
• W2983396687 hasConcept C2780559512 @default.
• W2983396687 hasConcept C2781244666 @default.
• W2983396687 hasConcept C54355233 @default.
• W2983396687 hasConcept C552990157 @default.
• W2983396687 hasConcept C60644358 @default.
• W2983396687 hasConcept C71924100 @default.
• W2983396687 hasConcept C72563966 @default.
• W2983396687 hasConcept C86803240 @default.
• W2983396687 hasConceptScore W2983396687C116567970 @default.
• W2983396687 hasConceptScore W2983396687C126322002 @default.
• W2983396687 hasConceptScore W2983396687C142724271 @default.
• W2983396687 hasConceptScore W2983396687C156957248 @default.
• W2983396687 hasConceptScore W2983396687C177336024 @default.
• W2983396687 hasConceptScore W2983396687C2776780178 @default.
• W2983396687 hasConceptScore W2983396687C2777714996 @default.
• W2983396687 hasConceptScore W2983396687C2778341716 @default.
• W2983396687 hasConceptScore W2983396687C2780559512 @default.
• W2983396687 hasConceptScore W2983396687C2781244666 @default.
• W2983396687 hasConceptScore W2983396687C54355233 @default.
• W2983396687 hasConceptScore W2983396687C552990157 @default.
• W2983396687 hasConceptScore W2983396687C60644358 @default.
• W2983396687 hasConceptScore W2983396687C71924100 @default.
• W2983396687 hasConceptScore W2983396687C72563966 @default.
• W2983396687 hasConceptScore W2983396687C86803240 @default.
• W2983396687 hasLocation W29833966871 @default.
• W2983396687 hasOpenAccess W2983396687 @default.
• W2983396687 hasPrimaryLocation W29833966871 @default.
• W2983396687 hasRelatedWork W10414013 @default.
• W2983396687 hasRelatedWork W14347477 @default.
• W2983396687 hasRelatedWork W15347163 @default.
• W2983396687 hasRelatedWork W16856531 @default.
• W2983396687 hasRelatedWork W19966934 @default.
• W2983396687 hasRelatedWork W2017735 @default.
• W2983396687 hasRelatedWork W3714693 @default.
• W2983396687 hasRelatedWork W5461392 @default.
• W2983396687 hasRelatedWork W8735064 @default.
• W2983396687 hasRelatedWork W9689379 @default.
• W2983396687 isParatext "false" @default.
• W2983396687 isRetracted "false" @default.
• W2983396687 magId "2983396687" @default.
• W2983396687 workType "article" @default.