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• W2983449871 abstract "The human ribonuclease RNase 7 has been originally isolated from human skin and is a member of the human RNase A superfamily. RNase 7 is constantly released by keratinocytes and accumulates on the skin surface. The expression of RNase 7 in keratinocytes can be induced by diverse stimuli such as cytokines, growth factors and microbial factors. RNase 7 exhibits a potent broad spectrum of antimicrobial activity against various microorganisms and contributes to control bacterial growth on the skin surface. The ribonuclease and antimicrobial activity of RNase 7 can be blocked by the endogenous ribonuclease inhibitor. There is also increasing evidence that RNase 7 exerts immunomodulatory activities and may participate in antiviral defense. In this review we discuss how these characteristics of RNase 7 contribute to innate cutaneous defense and highlight its role in skin infection and inflammation. We also speculate how a potential dysregulation of RNase 7 promotes inflammatory skin diseases and if RNase 7 may have therapeutic potential." @default.
• W2983449871 created "2019-11-22" @default.
• W2983449871 creator A5016730691 @default.
• W2983449871 creator A5061390049 @default.
• W2983449871 creator A5062097412 @default.
• W2983449871 creator A5071661573 @default.
• W2983449871 creator A5074088715 @default.
• W2983449871 creator A5082763772 @default.
• W2983449871 date "2019-11-05" @default.
• W2983449871 modified "2023-10-17" @default.
• W2983449871 title "The Antimicrobial and Immunomodulatory Function of RNase 7 in Skin" @default.
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• W2983449871 doi "https://doi.org/10.3389/fimmu.2019.02553" @default.
• W2983449871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6848066" @default.
• W2983449871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31749808" @default.
• W2983449871 hasPublicationYear "2019" @default.

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