FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983475569> ?p ?o ?g. }

• W2983475569 endingPage "514" @default.
• W2983475569 startingPage "508" @default.
• W2983475569 abstract "Background Unexplained or persistent leukocytosis is an increasing common cause of consultation to infectious disease physicians. Patients appear to be in a state of continued inflammation recently described as the persistent inflammation-immunosuppression and catabolism syndrome (PICS). Hospital course of such patients is frequently prolonged and associated with extensive use of empiric broad-spectrum antibiotics. We wished to determine the associated clinical features and outcome of such patients in anticipation of future specific diagnostic and therapeutic approaches to this syndrome. Methods We reviewed all infectious disease consultations from July 1, 2017, to March 31, 2018, for reason for consultation. Of those whose primary reason was “leukocytosis” or “bandemia,” each chart was assessed for demographics, reason for admission, hospital day of consultation, peak white blood cell count, infections and possible microbiological colonization, antibiotic use, and outcome. Results A total of 29 patients were identified, constituting 4.5% of consults during the study period. Cause of admission was sepsis in 7, major trauma 6, cerebrovascular accident 5, major elective surgery 4, ischemic leg 3, and 1 each lung mass, acute myocardial infarction, interstitial lung disease, and angioblastic lymphoma. Peak total leukocyte count (WBC) was 26.4K ± 8.8 on mean day 9.6 ± 5.5 days of hospitalization. Mean duration of leukocytosis greater than 11K was 14.5 ± 10.6 days. Peak percentage early myelocytic (“band”) leukocytes was 18.4 ± 13.8 and was of higher than 5% for a duration of 4.5 ± 5.6 days. Total eosinophilia count >500 was observed in 15 patients (range 500-2800) median hospital day 12. All patients received multiple and prolonged courses of broad-spectrum combination empiric antibiotics without apparent benefit either in terms of leukocytosis, signs of sepsis if present, or change in cultures, although those 7 with confirmed sepsis at admission tended to have shorter duration of leukocytosis and hospital course, whereas patients with trauma manifested greatest “bandemia.” Most patients became colonized with resistant opportunistic organisms, the most significant being Clostridium difficile enteritis in 6 patients. Hospitalization was prolonged, and most common disposition was to nursing home or rehabilitation (11 patients, mean day of discharge 21.6 ± 16.8) and home (8 patients, day 16.0 ± 9.3). Three patients died at mean hospital day 35.7 ± 29.7. Conclusions Except for 1 person with pelvic abscess post-cystectomy, patients appeared to have extensive tissue damage rather than active infection driving the leukocytosis. Patients appeared to meet clinical criteria for PICS that was substantiated by development of eosinophilia. Future studies should include direct measurements of the CD33CD11b+ myeloid suppressor cells, and the relative contribution of damage-associated molecular patterns (DAMPS) compared with pathogen-associated molecular patterns (PAMPS) such as endotoxin and other microbial products. More prudent and effective use of antibiotics could be possible." @default.
• W2983475569 created "2019-11-22" @default.
• W2983475569 creator A5033267196 @default.
• W2983475569 creator A5048496351 @default.
• W2983475569 date "2020-04-01" @default.
• W2983475569 modified "2023-09-26" @default.
• W2983475569 title "Inpatients With 'Unexplained' Leukocytosis" @default.
• W2983475569 cites W2307082245 @default.
• W2983475569 cites W2386572545 @default.
• W2983475569 cites W2519485429 @default.
• W2983475569 cites W2552785834 @default.
• W2983475569 cites W2588683822 @default.
• W2983475569 cites W2593515375 @default.
• W2983475569 cites W2758171977 @default.
• W2983475569 cites W2804288306 @default.
• W2983475569 cites W2809341712 @default.
• W2983475569 cites W2947594787 @default.
• W2983475569 doi "https://doi.org/10.1016/j.amjmed.2019.10.019" @default.
• W2983475569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31715161" @default.
• W2983475569 hasPublicationYear "2020" @default.
• W2983475569 type Work @default.
• W2983475569 sameAs 2983475569 @default.
• W2983475569 citedByCount "3" @default.
• W2983475569 countsByYear W29834755692022 @default.
• W2983475569 countsByYear W29834755692023 @default.
• W2983475569 crossrefType "journal-article" @default.
• W2983475569 hasAuthorship W2983475569A5033267196 @default.
• W2983475569 hasAuthorship W2983475569A5048496351 @default.
• W2983475569 hasConcept C126322002 @default.
• W2983475569 hasConcept C187212893 @default.
• W2983475569 hasConcept C2776694085 @default.
• W2983475569 hasConcept C2777063308 @default.
• W2983475569 hasConcept C2777802486 @default.
• W2983475569 hasConcept C2778384902 @default.
• W2983475569 hasConcept C2778488018 @default.
• W2983475569 hasConcept C2778923028 @default.
• W2983475569 hasConcept C71924100 @default.
• W2983475569 hasConcept C74133956 @default.
• W2983475569 hasConceptScore W2983475569C126322002 @default.
• W2983475569 hasConceptScore W2983475569C187212893 @default.
• W2983475569 hasConceptScore W2983475569C2776694085 @default.
• W2983475569 hasConceptScore W2983475569C2777063308 @default.
• W2983475569 hasConceptScore W2983475569C2777802486 @default.
• W2983475569 hasConceptScore W2983475569C2778384902 @default.
• W2983475569 hasConceptScore W2983475569C2778488018 @default.
• W2983475569 hasConceptScore W2983475569C2778923028 @default.
• W2983475569 hasConceptScore W2983475569C71924100 @default.
• W2983475569 hasConceptScore W2983475569C74133956 @default.
• W2983475569 hasIssue "4" @default.
• W2983475569 hasLocation W29834755691 @default.
• W2983475569 hasLocation W29834755692 @default.
• W2983475569 hasOpenAccess W2983475569 @default.
• W2983475569 hasPrimaryLocation W29834755691 @default.
• W2983475569 hasRelatedWork W1585452137 @default.
• W2983475569 hasRelatedWork W1966526032 @default.
• W2983475569 hasRelatedWork W1991876663 @default.
• W2983475569 hasRelatedWork W2170077128 @default.
• W2983475569 hasRelatedWork W2356553865 @default.
• W2983475569 hasRelatedWork W2896665262 @default.
• W2983475569 hasRelatedWork W2909264851 @default.
• W2983475569 hasRelatedWork W2980496224 @default.
• W2983475569 hasRelatedWork W2981964673 @default.
• W2983475569 hasRelatedWork W4313424397 @default.
• W2983475569 hasVolume "133" @default.
• W2983475569 isParatext "false" @default.
• W2983475569 isRetracted "false" @default.
• W2983475569 magId "2983475569" @default.
• W2983475569 workType "article" @default.