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- W2983607637 endingPage "140" @default.
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- W2983607637 abstract "Mesenchymal stem cells are defined as multipotent cells which have the ability to differentiate into various types of cell. Under the adipogenic stimuli, mesenchymal stem cells possess the ability to differentiate into adipocytes through adipogenesis processes. Adipogenesis is defined as the process of pre-adipocyte differentiation to mature adipocytes. Adipocytes are a type of cells with the ability to maintain energy balance through storage excess energy. However, several abnormal conditions including various types of disease can result from energy imbalance. Accordingly, obesity as a worldwide problem is one of the prevalent outcomes of increasing fat mass and there is a global effort to combat it. Accumulation of excess fat in adipocytes leads to adipocyte hypertrophy. Consequently, hypertrophic adipocyte can secrete several endocrine factors that induce hyperplasia (one of the major causes of obesity) and signal proliferation and differentiation of pre-adipocytes. Therefore, it has been demonstrated that adipogenic differentiation of mesenchymal stem cells undergoes different signaling pathways with various regulatory factors, while elucidation of these controllers can help scientists to develop more effective treatments for obesity and other related diseases. Therein, lipids have been presented as pivotal mediators of cellular processes and could induce several signaling pathways. Additionally, lipids are fundamental metabolites which use as cellular biomarkers to indicate different biological states and cellular activity. Total content of lipids in cells is known as lipidome. Any slight changes in the lipidome reflect different cellular changes. Tracking and comparing these changes between different stages of mesenchymal stem cell differentiation can provide identification of essential metabolic pathways involved in adipogenesis. In this context, lipidomics has been introduced as an emerging field of stem cell and regenerative medicine. Through the large-scale analysis of lipids, lipidomics provides more efficient methods to the investigation of adipocytes, and also prediction of the prognosis of obesity and its prevention and treatment." @default.
- W2983607637 created "2019-11-22" @default.
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- W2983607637 date "2019-01-01" @default.
- W2983607637 modified "2023-09-24" @default.
- W2983607637 title "Lipidomics of Adipogenic Differentiation of Mesenchymal Stem Cells" @default.
- W2983607637 cites W1694069654 @default.
- W2983607637 cites W1743490987 @default.
- W2983607637 cites W1779291233 @default.
- W2983607637 cites W1886286538 @default.
- W2983607637 cites W1955580249 @default.
- W2983607637 cites W1966455505 @default.
- W2983607637 cites W1975783279 @default.
- W2983607637 cites W1977950302 @default.
- W2983607637 cites W1978590803 @default.
- W2983607637 cites W1979026271 @default.
- W2983607637 cites W1980248069 @default.
- W2983607637 cites W1981322447 @default.
- W2983607637 cites W1985677799 @default.
- W2983607637 cites W1991895668 @default.
- W2983607637 cites W1992084001 @default.
- W2983607637 cites W1996221314 @default.
- W2983607637 cites W1997432717 @default.
- W2983607637 cites W2002033610 @default.
- W2983607637 cites W2004411749 @default.
- W2983607637 cites W2013857037 @default.
- W2983607637 cites W201463494 @default.
- W2983607637 cites W2016572177 @default.
- W2983607637 cites W2016701686 @default.
- W2983607637 cites W2016937049 @default.
- W2983607637 cites W2022390680 @default.
- W2983607637 cites W2027736364 @default.
- W2983607637 cites W2028261272 @default.
- W2983607637 cites W2029927816 @default.
- W2983607637 cites W2032850782 @default.
- W2983607637 cites W2036139926 @default.
- W2983607637 cites W2046054058 @default.
- W2983607637 cites W2047583719 @default.
- W2983607637 cites W2051705706 @default.
- W2983607637 cites W2057923834 @default.
- W2983607637 cites W2062279390 @default.
- W2983607637 cites W2064237012 @default.
- W2983607637 cites W2069234108 @default.
- W2983607637 cites W2073998126 @default.
- W2983607637 cites W2077145490 @default.
- W2983607637 cites W2087267340 @default.
- W2983607637 cites W2094569055 @default.
- W2983607637 cites W2098385948 @default.
- W2983607637 cites W2104085328 @default.
- W2983607637 cites W2116687544 @default.
- W2983607637 cites W2118290441 @default.
- W2983607637 cites W2125872855 @default.
- W2983607637 cites W2127031535 @default.
- W2983607637 cites W2131712788 @default.
- W2983607637 cites W2132042949 @default.
- W2983607637 cites W2135769482 @default.
- W2983607637 cites W2136558879 @default.
- W2983607637 cites W2138231163 @default.
- W2983607637 cites W2139473190 @default.
- W2983607637 cites W2150700075 @default.
- W2983607637 cites W2152221138 @default.
- W2983607637 cites W2153518194 @default.
- W2983607637 cites W2156360597 @default.
- W2983607637 cites W2157756843 @default.
- W2983607637 cites W2163711169 @default.
- W2983607637 cites W2166257115 @default.
- W2983607637 cites W2167669833 @default.
- W2983607637 cites W2171233986 @default.
- W2983607637 cites W2182559934 @default.
- W2983607637 cites W2207837055 @default.
- W2983607637 cites W2234203700 @default.
- W2983607637 cites W2284659436 @default.
- W2983607637 cites W2302646612 @default.
- W2983607637 cites W2341133396 @default.
- W2983607637 cites W2396164396 @default.
- W2983607637 cites W2406387703 @default.
- W2983607637 cites W2411828740 @default.
- W2983607637 cites W2417965300 @default.
- W2983607637 cites W2461926103 @default.
- W2983607637 cites W2473078753 @default.
- W2983607637 cites W2486975460 @default.
- W2983607637 cites W2518904228 @default.
- W2983607637 cites W2519479884 @default.
- W2983607637 cites W2521077735 @default.
- W2983607637 cites W2522015218 @default.
- W2983607637 cites W2530163063 @default.
- W2983607637 cites W2530492937 @default.