Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983634834> ?p ?o ?g. }
- W2983634834 endingPage "533" @default.
- W2983634834 startingPage "489" @default.
- W2983634834 abstract "Abstract Active phyto-constituents of Bacopa monnieri (L.) Wettst. (Scrophulariaceae) (synonyms: Bacopa monniera and Herpestis monniera) were identified as the dammarane-type triterpenoid saponins such as bacosides A and B. Later, bacoside A was determined as a mixture of four saponins viz. bacoside A3, bacopaside II, bacopasaponin C and the jujobogenin, an isomer of bacopasaponin C whereas the identity of bacoside B is still dubious. Bacosides and/or bacopasides were reported against morphine dependence, memory deficit in epilepsy, hepatocarcinogenesis, hepatotoxicity, β-amyloid cytotoxicity, inflammation and oxidative stress. B. monniera exhibits neuroprotective properties, nootropic and memory enhancing properties. Besides, it also improves concentration, comprehension, recall and alertness and is considered as a natural antioxidant implicated to neuroprotection. Neuroprotective role of the plant was manifested against diseases such as epilepsy, Parkinson's disease (PD), Alzheimer's disease (AD) associated dementia, attention-deficit hyperactivity disorder (ADHD) in children and anxiety. Many of these neuroprotective properties of B. monniera were attributed to the active phytochemicals bacosides and/or bacopasides. Unfortunately, little is known about the underlying mechanism of neuroprotection manifested by these dammarane-type triterpenoid saponins and very little systematic structure-activity relationship studies have been carried out. Therefore, information on structure-bioactivity relationships of these saponins, and development of their semi-synthetic derivatives are of immense importance in facilitating rational design of novel drugs based on leads from bacopasaponins. This review is focused on the origin, analysis of the pharmacological and medicinal properties and structural significance of bioactivities exerted by the bacopasaponins. Microbial regulation of bacoside A biosynthetic pathway and taking advantage of microbes for enhancing bacoside content are also discussed. Moreover, to unfold future research openings, lacunae in the present understanding are also highlighted. Together, this review may further direct to the synthetic optimization of bacopasaponins as lead compounds for the designing of efficacious and clinically acceptable analogs." @default.
- W2983634834 created "2019-11-22" @default.
- W2983634834 creator A5010329370 @default.
- W2983634834 creator A5010337533 @default.
- W2983634834 creator A5075061338 @default.
- W2983634834 date "2019-01-01" @default.
- W2983634834 modified "2023-10-14" @default.
- W2983634834 title "Advances in dammarane-type triterpenoid saponins from Bacopa monnieri: Structure, bioactivity, biotechnology and neuroprotection" @default.
- W2983634834 cites W1205605213 @default.
- W2983634834 cites W1499415591 @default.
- W2983634834 cites W1499552079 @default.
- W2983634834 cites W1538576959 @default.
- W2983634834 cites W1564827565 @default.
- W2983634834 cites W1643895934 @default.
- W2983634834 cites W1884137526 @default.
- W2983634834 cites W1898385603 @default.
- W2983634834 cites W1964240350 @default.
- W2983634834 cites W1967801816 @default.
- W2983634834 cites W1969905898 @default.
- W2983634834 cites W1970306448 @default.
- W2983634834 cites W1973163810 @default.
- W2983634834 cites W1975108157 @default.
- W2983634834 cites W1975457753 @default.
- W2983634834 cites W1977728948 @default.
- W2983634834 cites W1978072878 @default.
- W2983634834 cites W1979401268 @default.
- W2983634834 cites W1979655796 @default.
- W2983634834 cites W1980197921 @default.
- W2983634834 cites W1984687685 @default.
- W2983634834 cites W1986366255 @default.
- W2983634834 cites W1986987168 @default.
- W2983634834 cites W1987716123 @default.
- W2983634834 cites W1987953841 @default.
- W2983634834 cites W1990756453 @default.
- W2983634834 cites W1991238367 @default.
- W2983634834 cites W1992732899 @default.
- W2983634834 cites W1997544004 @default.
- W2983634834 cites W1998690998 @default.
- W2983634834 cites W1999407446 @default.
- W2983634834 cites W2002973989 @default.
- W2983634834 cites W2005621581 @default.
- W2983634834 cites W2007986071 @default.
- W2983634834 cites W2008403618 @default.
- W2983634834 cites W2010933451 @default.
- W2983634834 cites W2011024431 @default.
- W2983634834 cites W2017998260 @default.
- W2983634834 cites W2018301231 @default.
- W2983634834 cites W2019114077 @default.
- W2983634834 cites W2019927637 @default.
- W2983634834 cites W2020662867 @default.
- W2983634834 cites W2021582729 @default.
- W2983634834 cites W2023275395 @default.
- W2983634834 cites W2023545466 @default.
- W2983634834 cites W2023947260 @default.
- W2983634834 cites W2026036597 @default.
- W2983634834 cites W2028068902 @default.
- W2983634834 cites W2028409824 @default.
- W2983634834 cites W2028702925 @default.
- W2983634834 cites W2029213530 @default.
- W2983634834 cites W2030685175 @default.
- W2983634834 cites W2032306721 @default.
- W2983634834 cites W2033063632 @default.
- W2983634834 cites W2033918945 @default.
- W2983634834 cites W2035894356 @default.
- W2983634834 cites W2036977241 @default.
- W2983634834 cites W2040088065 @default.
- W2983634834 cites W2040530766 @default.
- W2983634834 cites W2041062243 @default.
- W2983634834 cites W2041068846 @default.
- W2983634834 cites W2041175897 @default.
- W2983634834 cites W2043217557 @default.
- W2983634834 cites W2043341916 @default.
- W2983634834 cites W2046554998 @default.
- W2983634834 cites W2046962241 @default.
- W2983634834 cites W2048841471 @default.
- W2983634834 cites W2048910667 @default.
- W2983634834 cites W2053230417 @default.
- W2983634834 cites W2059013170 @default.
- W2983634834 cites W2060960573 @default.
- W2983634834 cites W2061658400 @default.
- W2983634834 cites W2062244039 @default.
- W2983634834 cites W2063645237 @default.
- W2983634834 cites W2067633335 @default.
- W2983634834 cites W2070467200 @default.
- W2983634834 cites W2071303476 @default.
- W2983634834 cites W2072318368 @default.
- W2983634834 cites W2075265682 @default.
- W2983634834 cites W2076881997 @default.
- W2983634834 cites W2077034458 @default.
- W2983634834 cites W2079561020 @default.
- W2983634834 cites W2082640750 @default.
- W2983634834 cites W2083746781 @default.
- W2983634834 cites W2085138377 @default.
- W2983634834 cites W2086137075 @default.
- W2983634834 cites W2087584553 @default.
- W2983634834 cites W2090592622 @default.
- W2983634834 cites W2092806875 @default.
- W2983634834 cites W2094533030 @default.